Main Article Content

Олег Иванович Бондарев
Нина Васильевна Мальцева
Арнольд Михайлович Сурков
Ирина Анатольевна Бондарева
Павел Алексеевич Азаров

Abstract

The subject of the study (observations). Questions of the apoptotic process in the development of fibroplastic changes in pneumoconiosis in miners.

The purpose of the study – to substantiate the contribution of the genetic factor associated with genome polymorphism in the development of dust pathology in miners. Identification of gene variants as markers of individual predisposition to the development of pneumoconiosis.

Research methods. Theoretical basis.

Keywords

fibroplastic changes, dust pathology, pneumoconiosis, gene polymorphism, apoptosis

Author Biographies

Олег Иванович Бондарев,

Oleg I. Bondarev

Candidate of Medical Sciences, head of the research laboratory for pathological anatomy

Нина Васильевна Мальцева,
doctor of biological sciences, head of the research laboratory of molecular biology
Арнольд Михайлович Сурков,
candidate of medical sciences, assistant of the department of pathological anatomy and forensic medicine
Ирина Анатольевна Бондарева,
doctor of clinical laboratory diagnostics
Павел Алексеевич Азаров,
candidate of medical sciences, assistant of the department of pathological anatomy and forensic medicine

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.

How to Cite

Бондарев, О. И., Мальцева, Н. В., Сурков, А. М., Бондарева, И. А., & Азаров, П. А. (2022). APOPTOTIC ACTIVITY AS A TRIGGER MECHANISM OF SYSTEMIC FIBROSIS OF INTERNAL ORGANS IN MINERS. Medicine in Kuzbass, 21(3), 111-114. https://doi.org/10.24412/2687-0053-2022-3-111-114

References

Vismont FI. Inflammation (pathophysiological aspects): Uch. method. manual. Mn: BSMU, 2006. 48 p. Russian (Висмонт Ф.И. Воспаление (патофизиологические аспекты): Уч. метод. пособие. Мн.: БГМУ, 2006. 48 с.)

Kidane D, Chae WJ, Czochor J, et al. Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol. 2014; 49(2): 116-139. doi: 10.3109/10409238.2013.875514

Brito HO, Barbosa FL, dos Reis RC, et al. Evidence of substance P autocrine circuitry that involves TNF-a, IL-6, and PGE2 in endogenous pyrogen-induced fever. J Neuroimmun. 2016; 293: 1-7

Yang X, Qin M, Cui S, et al. Associations of VDR gene polymorphisms with risk of coal workers’ pneumoconiosis in Chinese Han population. Toxicol Res (Camb). 2020; 9(4): 399-405. doi:10.1093/toxres/tfaa038

Yuan B, Yuan W, Wen X, et al. Association of single nucleotide polymorphisms in the CYBA gene with coal workers’ pneumoconiosis in the Han Chinese population. Inhal Toxicol. 2018; 30(13-14): 492-497. doi: 10.1080/08958378.2018.1558315

Konkel JE, Chen W. Balancing acts: the role of TGF-β in the mucosal immune system. Trends Mol Med. 2011; 17(11): 668-676. doi: 10.1016/j.molmed.2011.07.002

Wang JK, Feng ZW, Li YC, et al. Association of tumor necrosis factor – a gene promoter polymorphism at sites -308 and -238 with non-alcoholic fatty liver disease: a meta-analysis. J Gastroenterol Hepatol. 2012; 27: 670-676. doi: 10.1111/j.1440-1746.2011.06978

Gerasimova ON, Sigalovich EU, Dankovtseva EN, Nakonechnikov SN, Nikitin AG, Ivanova ZV, et al. The relationship of the carrier of the allele A of the polymorphic marker G(-238)A TNF-a gene with an unfavorable prognosis in patients with chronic systolic heart failure. Cardiology. 2015; 55(9): 25-30. Russian (Герасимова О.Н., Сигалович Е.Ю., Данковцева Е.Н., Наконечников С.Н., Никитин А.Г., Иванова З.В. и др. Связь носительства аллеля A полиморфного маркера G(-238)A гена TNF-A с неблагоприятным прогнозом у больных с хронической систолической сердечной недостаточностью //Кардиология. 2015. Т. 55, № 9. С. 25-30.) doi: 10.18565/кардио.2015.9.25-30

Karimi M, Goldie LC, Cruickshank MN, et al. A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of -308 TNF polymorphism function using a novel integrated reporter system. Eur J Hum Genet. 2009; 17: 1454-1462. doi: 10.1038/ejhg.2009.80

Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001; 104: 487-501. doi: 10.1016/s0092-8674(01)00237-9

Cabal-Hierro L, Lazo PS. Signal transduction by tumor necrosis factor receptors. Cellular Signalling. 2012; 24: 1297-1305. doi: 10.1016/j.cellsig.2012.02.006

Tarrats N, Moles A, Morales A, García-Ruiz C, Fernández-Checa JC, Marí M. Critical role of tumor necrosis factor receptor 1, but not 2, in hepaticstellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology. 2011; 54: 319-327. doi: 10.1002/hep.24388

Li-Teng Yang, Xin Liu, Gao-Hui Wu, Li-Fang Chen. Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. Inhal Toxicol. 2018; 30(6): 213-217. doi: 10.1080/08958378.2018.1494766

Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, et al. Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome С. J Clin Investig. 2000; 106: 1127-1137. doi: 10.1172/JCI9914

Downloads

Download data is not yet available.

Most read articles by the same author(s)

1 2 3 > >>