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Abstract
Gigantomastia (macromastia, hypermastia) is a rare disease associated with excessive hypertrophy of the connective tissue of the breast in women.
Gestational gigantomastia is a type of disease, the most common type. It develops during pregnancy under the influence of hormonal surges of progesterone, prolactin, and estradiol. More often, gigantomastia is bilateral, less often-unilateral. The disease occurs in one case per 28000-100000 pregnancies. As a rule, the condition develops in the first trimester under the influence of placental hormones. The consequences of the disease are more often observed in women with multiple pregnancies. Approximately 150 cases of gestational gigantomastia have been reported. After childbirth, in some cases, the breasts return to their postpartum state, but with subsequent pregnancy they increase again, usually more significantly. The condition threatens the health of the mother, but has a good outcome for the fetus.
Despite the benign nature of gigantomastia, it can cause a dangerous condition and even death from severe infection and cardiopulmonary failure. This article describes a rare clinical case of gestational gigantomastia. Taking into account the optimal chosen management tactics of the patient, a relatively favorable outcome of pregnancy and childbirth for the mother and fetus was obtained.
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Rutherford CL, Hsieh MKH, Tan H-M, Twoon M, Kong TY. A Rare Case of Persistent Unilateral Gestational Gigantomastia. Plast Reconstr Surg Glob Open. 2019; 7(8): e2372. DOI: 10.1097/GOX. 0000000000002372
Das L, Rai A, Vaiphei K, Garg A, Mohsina S, Bhansali A, et al. Idiopathic gigantomastia: newer mechanistic insights implicating the paracrine milieu. Endocrine. 2019; 66(2): 166-177. DOI: 10.1007 / s12020-019-02065-x
Türkan H, Gökgöz MŞ, Taşdelen İ, Dündar HZ. Gestational Gigantomastia. J Breast Health. 2016; 12(2): 86-87. DOI: 10.5152/tjbh. 2016.2852
Cho MJ, Yang J-H, Choi H-G, Kim WS, Yu Y-B, Park KS. An idiopathic gigantomastia. Ann Surg Treat Res. 2015; 88(3): 166-169. DOI: 10.4174/astr. 2015.88.3.166
Wolfswinkel EM, Lemaine V, Weathers WM, Chike-Obi CJ, Xue AS, Heller L. Hyperplastic Breast Anomalies in the Female Adolescent Breast. Semin Plast Surg. 2013; 27(1): 49-55. DOI: 10.1055/s-0033-1347167
Debra Rose Wilson. What Is Gigantomastia? //healthline.com. 2017; 8
Rabail Raza, Kulsoom Fatima. Gigantomastia: A case report with review of literature. Open Journal of Clinical & Medical Case Reports. 2017; 3
Swelstad MR, Swelstad BB, Rao VK, Gutowski KA. Management of gestational gigantomastia. Plast Reconstr Surg. 2006; 118(4): 840-848
Fatma Dilek Dellal, Didem Ozdemir, Cevdet Aydin, Gulfem Kaya, Reyhan Ersoy, and Bekir Cakir. Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature. Case Reports in Endocrinology. 2016; 2: 1-5. DOI: 10.1155/2016/3576024
Ji Hyeon Cha, Hak Hee Kim, Sun Mi Kim, Myung Hee Seo, Hoi Soo Yoon. Breast Gigantism Induced by D-Penicillamine: Case Report. J Korean Radiol Soc. 2004; 50: 213-215
Elgina SI, Ushkova GA, Niklina EN. Reproductive system of full-term and premature newborn girls. Fundamental and clinical medicine. 2016; 1(3): 39-45. Russian (Елгина С.И., Ушакова Г.А., Никулина Е.Н. Репродуктивная система доношенных и недоношенных новорожденных девочек //Фундаментальная и клиническая медицина. 2016. № 1(3). С. 39-45)
Nikolaeva LB, Ushakova GA, Elgina SI. Forecast of population reproduction and reproductive health of girls of Kuzbass. Mother and Baby in Kuzbass. 2010; 1(40: 19-27. Russian (Николаева Л.Б., Ушакова Г.А., Елгина С.И. Прогноз воспроизводства населения и репродуктивное здоровье девочек Кузбасса //Мать и Дитя в Кузбассе. 2010. № 1(40). С. 19-27)
Eligna SI. Clinical assessment of the reproductive system of newborn girls and prediction of violations of its formation. Reproductive health of children and adolescents. 2009; 1: 43-47. Russian (Елгина С.И. Клиническая оценка репродуктивной системы новорожденных девочек и прогнозирование нарушений ее становления //Репродуктивное здоровье детей и подростков. 2009. № 1. С. 43-47)
Apykhtina NA, Elgina SI. Reproductive health of adolescent girls in the Kemerovo region. Reproductive health of children and adolescents. 2016; 2: 30-31. Russian (Апыхтина Н.А., Елгина С.И. Репродуктивное здоровье девочек-подростков Кемеровской области //Репродуктивное здоровье детей и подростков. 2016. № 2. С. 30-31)
Talghini S. Is macromastia a risk factor for breast cancer? A study on 198 patients. Pak J Biol Sci. 2013;16(21): 1348-1352
Ezem BU, Osuagwu СС, Opara KA. Gestational gigantomastia with complete resolution in a Nigerian woman. BMJ Case Rep. 2011; 2011: bcr0120102632. DOI: 10.1136/bcr.01.2010.2632