GENDER FEATURES OF THE STRUCTURE OF COLON EPITHELIAL NEOPLASMS
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Abstract
The aim of the research – the article is devoted to the evaluation of the structure of epithelial neoplasms in different parts of the colon due to the gender of the patient.
Materials and methods. A retrospective, pooled analysis of 3086 videocolonoscopies from 2019-2020.
Results. The total frequency of detected neoplasms amounted to 1431 in 980 patients (31.8 %). Assessment of the frequency of detection of nonvillous adenomas by levels of the colon revealed significant gender differences in the cecum, descending colon, and rectum. The frequency of such adenomas had no significant level-by-level differences. Villous adenomas and carcinomas had no gender differences , their frequency in the sigmoid colon and rectum exceeded that in the proximal colon. The frequency of LST also had no gender differences, but their localization in the ascending, transverse and sigmoid colon exceeded that in other parts. The structure of epithelial neoplasms had significant gender differences in the cecum, descending colon and rectum.
Conclusion. There are gender differences in the structure of tumors in the blind, descending and rectum. No significant differences in the overall frequency of diagnosis of colorectal malignant neoplasms by gender were found.
Keywords
Author Biographies
Алексей Григорьевич Короткевич,
doctor of medical sciences, professor, professor of the department of surgery, urology, endoscopy and pediatric surgery
Наталья Михайловна Жилина,
doctor of technical sciences, docent, head of the department of medical cybernetics and informaticsArticle Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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References
Leifer OV, Ivanov IV, Savchuk KS, Korostelev MY. Colon oncology: issues of oncogenesis and epidemiology in Novgorod region. Vestnik of Yaroslav the Wise Novgorod State University. 2021; 3(124): 103-106. Russian (Лейфер О.В., Иванов И.В., Савчук К.С., Коростелев М.Ю. Рак толстой кишки: вопросы онкогенеза и эпидемиологии на примере Новгородской области //Вестник Новгородского государственного университета. 2021. № 3(124). С. 103-106)
Hultcrantz R. Aspects of colorectal cancer screening, methods, age and gender. J Intern Med. 2021; 289(4): 493-507. DOI: 10.1111/joim.13171
Gataullin BI. Gender features of colorectal cancer. Literature review. Povolozhsky Oncological Bulletin. 2020; 11(2(42)): 37-42. Russian (Гатауллин Б.И. Гендерные особенности колоректального рака. Обзор литературы //Поволжский онкологический вестник. 2020. Т. 11, № 2(42). С. 37-42)
Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, et al. Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes. Curr Drug Targets. 2021; 22(9): 998-1009. DOI: 10.2174/1389450121999201117115717
Kastrinos F, Kupfer SS, Gupta S. Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart? Gastroenterology. 2023; 164(5): 812-827. DOI: 10.1053/j.gastro.2023.02.021
Grundmann RT, Meyer F. Gender-specific influences on incidence, screening, treatment, and outcome of colorectal cancer. Zentralbl Chir. 2013; 138(4): 434-441. DOI: 10.1055/s-0033-1350631
Kim HM, Kim HS. Gender-specific colorectal cancer: epidemiologic difference and role of estrogen. Korean J Gastroenterol. 2014; 63(4): 201-208. DOI: 10.4166/kjg.2014.63.4.201
Burtsev DV. Effectiveness screening of colon tumors at the Regional Consultative and Diagnostic Centre. Practical medicine. 2012; 2(57): 214-217. Russian (Бурцев Д.В. Эффективность скрининга опухолей толстой кишки на базе регионального консультативно-диагностического центра //Практическая медицина. 2012. № 2(57). С. 214-217)
Kit OI, Dzhenkova EA, Mirzojan JeA, Gevorkjan JuA, Sagakjanc AB, Timoshkina NN, et al. Molecular genetic classification of colorectal cancer subtypes: current state of the problem. South Russian Journal of Cancer. 2021: 2(2): 50-56. Russian (Кит О.И., Дженкова Е.А., Мирзоян Э.А., Геворкян Ю.А., Сагакянц А.Б., Тимошкина Н.Н., и др. Молекулярно-генетическая классификация подтипов колоректального рака: современное состояние проблемы //Южно-Российский онкологический журнал. 2021. Т. 2, № 2. С. 50-56)
Fedyanin MYu, Tryakin AA, Tyulandin SA. Localization of the primary tumor of the colon: аre there essential differences? Colorectal oncology. 2017; 7(3): 35-48. Russian (Федянин М.Ю., Трякин А.А., Тюляндин С.А. Локализация первичной опухоли толстой кишки: есть ли принципиальные отличия? //Онкологическая колопроктология. 2017. Т. 7, № 3. С. 35-48.) DOI: 10.17650/2220-3478-2017-7-3-35-48
Sun X, Zhao D, Long S, Chen S, Cai Q, Yao S. Clinicopathological and molecular features of colorectal cancer with synchronous adenoma. Scand J Gastroenterol. 2020; 55(9): 1063-1071. DOI: 10.1080/00365521.2020.1795922
Mishchenko IM. Role of endoscopic examination of the colon in the prevention of colorectal cancer. Sovremennaya patologiya: opy`t, problemy`, perspektivy`: Materialy` I Vserossijskoj nauchno-prakticheskoj konferencii s mezhdunarodny`m uchastiem. Samara, 2020. P. 283-287. Russian (Мищенко И.М. Роль эндоскопического исследования толстой кишки в профилактике колоректального рака //Современная патология: опыт, проблемы, перспективы: Матер. I Всерос. науч.-практ. конф. с междунар. участием. Самара, 2020. С. 283-287)
Smagulova KK, Turkpenova IT, Shajahmetova DU, Dzhumanov AI, Esenkulova SA. The role of microsatellite instability in colorectal cancer: a literature review. Oncology and Radiology of Kazakhstan. 2022; 3(65): 47-51. Russian (Смагулова К.К., Туркпенова И.Т., Шаяхметова Д.У., Джуманов А.И., Есенкулова С.А. Роль микросателлитной нестабильности при колоректальном раке: обзор литературы //Онкология и радиология Казахстана. 2022. № 3(65). С. 47-51)
Medvedeva EA, Maryin GG, Leshchenko AA, Chernogorova MV, Dolgova MB, Nazarov DA, Ivanov SA. Global burden of colorectal cancer: epidemiology, risk factors. Research and Practical Medicine Journal. 2022; 9(4): 134-146. Russian (Медведева Е.А., Марьин Г.Г., Лещенко А.А., Черногорова М.В., Долгова М.Б., Назаров Д.А., Иванов С.А. Глобальное бремя колоректального рака: эпидемиология, факторы риска //Исследования и практика в медицине. 2022. Т. 9, № 4. С. 134-146.) DOI: 10.17709/2410-1893-2022-9-4-13
Afonin GA, Baltaev NA, Kajdarova DR, Ababakriev AK, Kalmenova PB. Clinical and phenotypic variants of hereditary and sporadic colorectal cancer in patients of young age. Oncology and Radiology of Kazakhstan. 2021; 2(60): 9-21. Russian (Афонин Г.А., Балтаев Н.А., Кайдарова Д.Р., Абабакриев А.К., Калменова П.Б. Клинико-фенотипические варианты наследственного и спорадического колоректального рака у больных молодого возраста //Онкология и радиология Казахстана. 2021. № 2(60). С. 9-21)
Krashenkov OP, Kostin AA, Konovalov OE. Genderny`e osobennosti zabolevaemosti kolorektal`ny`m rakom. Sovremenny`e problemy` e`pidemiologii, mikrobiologii i gigieny`: Materialy` XV Vserossijskoj nauchno-prakticheskoj konferencii molody`x ucheny`x i specialistov Rospotrebnadzora. Nizhnij Novgorod, 2023. P. 102-105. Russian (Крашенков О.П., Костин А.А., Коновалов О.Е. Гендерные особенности заболеваемости колоректальным раком. //Современные проблемы эпидемиологии, микробиологии и гигиены: Матер. XV Всерос. науч.-практ. конф. молодых ученых и специалистов Роспотребнадзора. Нижний Новгород, 2023. С. 102-105)