INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS
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Abstract
The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any inflammatory process, including allergic inflammation. The review article describes a structure, major activation signals, NLRP1 activation process, and assotiation with human disease, focusing on atopic conditions, such as atopic dermatitis, allergic rhinitis, and allergic asthma, and provides a rationale for the link of mutations in the NLRP1 sensor gene with genes corresponding to atopy predisposition. The association of NLRP1 with malignant neoplasms is also reported.
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Anderton H, Alqudah S. Cell death in skin function, inflammation, and disease. Biochem J. 2022; 479: 1621-1651. doi: 10.1042/BCJ20210606
Angosto-Bazzara D, Molina-López C, Peñín-Franch A, Hurtado-Navarro L, Pelegrín P. Techniques to study inflammasome activation and inhibition by small molecules. Molecules. 2021; 26(6): 1704. doi: 10.3390/molecules26061704
Bachovchin DA. NLRP1: a jack of all trades, or a master of one? Mol Cell. 2022; 81(3): 423-425. doi: 10.1016/j.molcel.2021.01.001
Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V. Human NLRP1 is a sensor for double-stranded RNA. Science. 2021; 371(6528): eabd0811. doi: 10.1126/science.abd0811
Bergougnan C, Dittlein DC, Hümmer E, Riepl R, Eisenbart S, Böck D, et al. Physical and immunological barrier of human primary nasal epithelial cells from non-allergic and allergic donors. WAO J. 2020; 13: 100109. doi: 10.1016/j.waojou.2020.100109
Bittner ZA, Schrader M, George SE, Amann R. Pyroptosis and its role in SARS-CoV-2 infection. Cells. 2022; 11: 1717. doi: 10.3390/cells11101717
Burian M, Yazdi AS. NLRP1 Is the Key Inflammasome in primary human keratinocytes. J Invest Dermatol. 2018; 138: 2507-2510. doi: 10.1016/j.jid.2018.08.004
Christgen S, David E, Place DE, Kanneganti T-D. Toward targeting inflammasomes: Insights into their regulation and activation. Cell Res. 2020; 30: 315-327. doi: 10.1038/s41422-020-0295-8
Ciążyńska A, Bednarski IA, Wódz K, Narbutt J, Lesiak A. NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncol Letters. 2020; 19: 1649-1656. doi: 10.3892/ol.2020.11284
Cyr B, Hadad R, Keane RW, Vaccari JPR. The role of non-canonical and canonical inflammasomes in inflammaaging. Front Mol Neurosci. 2022; 15: 774014. doi: 10.3389/fnmol.2022.774014
Danis J, Mellett M. Nod-Like receptors in host defence and disease at the epidermal barrier. Int J Mol Sci. 2021; 22: 4677. doi: 10.3390/ijms22094677
Di Filippo M, Hennig P, Karakaya T, Slaufova M, Beer H-D. NLRP1 in cutaneous SCCs: An example of the complex roles of inflammasomes in cancer development. Int J Mol Sci. 2022; 23: 12308. doi: 10.3390/ijms232012308
Dmitriev YuV, Galagudza MM. Neсroptosis and the experience of its targeted modulation in the context of personalized medicine. Russian Journal for Personalized Medicine. 2022; 2(2): 33-45. Russian (Дмитриев Ю.В., Галагудза М.М. Некроптоз и опыт его таргетной модуляции в контексте персонализированной медицины //Российский журнал персонализированной медицины. 2022; 2(2): 33-45.) doi: 10.18705/2782-3806-2022-2-2-33-45
Ekman AK, Verma D, Fredrikson M, Bivik C, Enerbäck C. Genetic variations of NLRP1: susceptibility in psoriasis. Br J Dermatol. 2014; 171(6): 1517-1520. doi: 10.1111/bjd.13178
Fenini G, Karakaya T, Hennig P, Di Filippo M, Beer HD. The NLRP1 inflammasome in human skin and beyond. Int J Mol Sci. 2020; 21(13): 4788. doi: 10.3390/ijms21134788
Gruber JV, Holtz R. In vitro expression of NLRP inflammasome-induced active Caspase-1 expression in normal human epidermal keratinocytes (NHEK) by various exogenous threats and subsequent inhibition by naturally derived ingredient blends. J Inflam Res. 2019; 12: 219-230. doi: 10.2147/JIR.S215776
Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, et al. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med. 2018; 10(4): e8689. doi: 10.15252/emmm.201708689
Jenster L-M, Lange K-E, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, et al. P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J Exp Med. 2023; 220(1): e20220837. doi: 10.1084/jem.20220837
Klimov VV. Textbook of allergen tolerance. Cham: Springer, 2022. 326 p.
Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T, et al. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet. 2001; 28(1): 87-91. doi: 10.1038/ng0501-87
Lara-Reyna S, Caseley EA, Topping J, Rodrigues F, Jimenez Macias J, Lawler SE, McDermott MF. Inflammasome activation: from molecular mechanisms to autoinflammation. Clin Transl Immunol. Clin Transl Immunology. 2022; 11(7): e1404. doi: 10.1002/cti2.1404
Lillo S, Saleh M. Inflammasomes in cancer progression and anti-tumor immunity. Front. Cell Dev Biol. 2022; 10: 839041. doi: 10.3389/fcell.2022.839041
Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspase and processing of proIL-beta. Mol Cell. 2002; 10: 417-426. doi: 10.1016/s1097-2765(02)00599-3
Mitchell PS, Sandstrom A, Vance RE. The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries. Curr Opin Immunol. 2019; 60: 37-45. doi: 10.1016/j.coi.2019.04.015
Möcking J. Investigating the molecular basis of human NLRP1 inflammasome activation. The Rheinische Friedrich-Wilhelms-Universität Bonn, University of Melbourne. Thesis. Bonn/Melbourne, 2020. 238 p. https://nbn-resolving.org/urn:nbn:de:hbz:5-57831
Murase Y, Takeichi T, Koseki J, Miyasaka Y, Muro Y, Ohno T, et al. UVB-induced skin autoinflammation due to NLRP1b mutation and its inhibition by anti-IL-1β antibody. Front Immunol. 2022; 13: 876390. doi: 10.3389/fimmu.2022.876390
Nagar A, Rahman T, Harton JA. The ASC Speck and NLRP3 inflammasome function are spatially and temporally distinct. Front Immunol. 2021; 12: 752482. doi: 10.3389/fimmu.2021.752482
Nasonov EL. The role of interleukin 1 in the development of human diseases. Rheumatology Science and Practice. 2018; 56(S4): 19-27 Russian (Насонов Е.Л. Роль интерлейкина 1 в развитии заболеваний человека //Научно-практическая ревматология. 2018. Т. 56, № S4. С. 19-27.) doi: 10.14412/1995-4484-2018-19-27
Ortiz RA, Barnes KC. Genetics of allergic diseases. Immunol Allergy Clin North Am. 2015; 35(1): 19-44. doi:10.1016/j.iac.2014.09.014
Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, et al. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022; 82(13): 2385-2400.e9. doi: 10.1016/j.molcel.2022.04.033
Pontillo A, Girardelli M, Kamada AJ, Pancotto JA, Donadi EA, Crovella S, Sandrin-Garcia P. Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. Autoimmunity. 2012; 45(4): 271-278. doi: 10.3109/08916934.2011.637532
Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, et al. Live cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem. 2017; 292(35): 14649-14658. doi: 10.1074/jbc.M117.797217
Robinson KS, Teo DET, Tan KS, Toh GA, Ong HH, Lim CK, et al. Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. Science. 2020; 370(6521): eaay2002. doi: 10.1126/science.aay2002
Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019; 364: 6435. doi: 10.1126/science.aau1330Arend
Tang L, Zhou F. Inflammasomes in common immune-related skin diseases. Front Immunol. 2020; 11: 882. doi: 10.3389/fimmu.2020.00882
Tsang MS-M, Hou T, Chan BC-L, Wong CK. Immunological roles of NLR in allergic diseases and its underlying mechanisms. Int J Mol Sci. 2021; 22: 1507. doi: 10.3390/ijms22041507
Weidinger S, Klopp N, Rummler L, Wagenpfeil S, Novak N, Baurecht HJ, et al. Association of NOD1 polymorphisms with atopic eczema and related phenotypes. J Allergy Clin Immunol. 2005; 116(1): 177-184. doi: 10.1016/j.jaci.2005.02.034
Zheng D, Liwinski T, Elinav E. Inflammasome activation and regulation: toward a better understanding of complex mechanisms. Cell Discov. 2020; 6(1): 36. doi: 10.1038/s41421-020-0167-x
Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, et al. Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation. Cell. 2016; 167: 187-202.e17. doi: 10.1016/j.cell.2016.09.001