HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS
Main Article Content
Abstract
Objective – to study the presence and significance of human papillomavirus and Epstein-Barr virus in the development of chronic hyperplastic laryngitis and evaluate the effectiveness of immunomodulating therapy in the treatment of the disease.
Methods. Thirty men with chronic hyperplastic laryngitis aged 30 to 70 years were examined. The comparison group consisted of 30 healthy men over the age of 29 years. The determination of human papillomavirus was carried out by polymerase chain reaction. Antibodies to Epstein-Barr virus antigens were investigated by enzyme immunoassay.
Results. Among patients with chronic hyperplastic laryngitis, HPV infection was 50 %: HPV was detected in 15 of the 30 samples studied. At the same time, HPV of type 11 was detected in 3 patients; in 12 cases, human papillomaviruses of high oncogenic risk were detected – genotypes 16, 18, 31, 31. Indirect laryngoscopy revealed diffuse hyperplasia of all sections of the laryngeal mucosa in 9 (30 %) patients with chronic hepatitis C and there was uneven mucosal hyperplasia and its hyperemia in 21 (70 %). Antibodies to capsid and early Epstein-Barr virus antigens were tested in 21 patients with chronic hepatitis C (70 %).
Conclusions. The detection of HPV of high oncogenic risk in chronic hepatitis C, the presence of high titers of specific antibodies characterizing the immune response to the Epstein-Barr virus, indicates the activation of the virus in the body of patients with chronic hyperplastic laryngitis. Conducted comprehensive treatment with the inclusion of an inducer of interferon - cycloferon gives a visible clinical effect in the treatment of this category of patients.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Stepanova YE. New methods for diagnosis of disease of the larynx. Doctor.ru. 2009; 5: 31-34. Russian (Степанова Ю.Е. Современные методы диагностики заболеваний гортани //Доктор.Ру. 2009. № 5. С. 31-34)
Muhamedov MR, Cheremisina OV, Choinzonov EL, Kulbakin DE, Balatskaya LN, Vasiliev NV, Gunther VE. The modern view on complex approach when diagnosing, treating and aftercaring in larynx cancer patients. Russian otolaryngology. 2012; 3(58): 78-84. Russian (Мухамедов М.П., Черемисина О.В., Чойнзонов Е.Л., Кульбакин Д.Е., Балацкая Л.Н., Васильев Н.В., Гюнтер В.Э. Современный взгляд на комплексный подход к диагностике, лечению и реабилитации больных раком гортани //Российская оториноларингология. 2012. № 3(58). С. 78-84)
Cheremisina OV, Choinzonov EP. Potentials of endoscopic diagnosis of precancer diseases and cancer of the larynx. Siberian Jornal of Oncology. 2007; 3: 5-10. Russian (Черемисина О.В., Чойнзонов Е.Л. Возможности эндоскопической диагностики предопухолевых заболеваний и рака гортани в современной онкологии //Сибирский онкологический журнал. 2007. № 3. С. 5-10)
Paches AI. Head and neck tumors. M.: Practical Medicine, 2013. 478 p. Russian (Пачес А.И. Опухоли головы и шеи. М.: Практическая медицина, 2013. 478 с.)
Cheremisina OV, Choinzonov EL, Pankova OV, Menshikov KYu. Chronic hypeplastic laryngitis as a criterion for defining groups at high risk of laryngeal cancer. Russian otorhinolaryngology. 2012; 2(63): 84-89. Russian (Черемисина О.В., Чойнзонов Е.Л., Панкова О.В., Меньшиков К.Ю. Хронический гиперпластический ларингит как критерий формирования группы риска по раку гортани //Российская оториноларингология. 2013. № 2(63). С. 84-89)
Baletic N, Petrovic Z, Pendjer Y, Malicevic H. Autofluorescent diagnostics in laryngeal pathology. Eur. Otorhinolaryngol. 2004; 261: 233-237
HPV infection of the urogenital tract of women (epidemiology, clinical and pathogenetic features, methods of diagnosis, treatment, prevention): informational-methodical manual /Folyak EV, Sokolova TM, Makarov KY, Yakimova AV, Mukhamedshina VR, Usova AV. Novosibirsk, 2010. 88 p. Russian (Папилломавирусная инфекция урогенитального тракта женщин (эпидемиология, клинико-патогенетические особенности, методы диагностики, лечение, профилактика): информационно-методическое пособие /Фоляк Е.В., Соколова Т.М., Макаров К.Ю., Якимова А.В., Мухамедшина В.Р., Усова А.В. Новосибирск: Вектор-Бест, 2010. 88 c.)
Rogovskaya SI. Papillomavirus infection in women and pathology of the cervix [Electronic resource]. M.: GEOTAR-Media, 2014. 192 p. Access mode: https://www.rosmedlib.ru/book/ISBN9785970428733.html. Russian (Роговская С.И. Папилломавирусная инфекция у женщин и патология шейки матки [Электронный ресурс]. М.: ГЭОТАР-Медиа, 2014. 192 с. Режим доступа: https://www.rosmedlib.ru/book/ISBN9785970428733.html)