THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY
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Abstract
Objective. In the study included 45 patients with isolated severe traumatic brain injury in the acute period of this disease. Two groups were identified: the first group – 20 surviving patients, the second group – 25 deceased patients. The study to shown the role of catecholamines in the development of immunosuppression in the acute period of the severe traumatic brain injury.
Methods. On the 1st, 3rd, 5th day after severe traumatic brain injury we determined the subpopulations of lymphocytes by the presence of surface cellular antigens. We used the method of indirect immunofluorescence with monoclonal antibodies on cytofluorimeter «Citomix FC500» for determining CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes. We determined the levels of epinephrine and norepinephrine in urine by the kit «CatCombi» (ELISA) on the 1st and 3rd day of the post-traumatic period.
Conclusions. The raise of the levels epinephrine and norepinephrine in severe traumatic brain injury adduce to the failure of the cellular immunity with decrease the subpopulations of lymphocytes: CD3+, CD4+, CD8+, CD16+ lymphocytes.
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Dünser MW, Hasibeder WR. Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med. 2009; 24(5): 293-316
Aleksandrova EV, Tonoyan AS, Sychev AA, Kryukova KK. The Activity of Sympathoadrenal System in the Acute Phase of Severe Traumatic Brain Injury: the Importance of Neuroanatomical Factors. The RFFI Bulletin. 2016; 2(90): 41-49. Russian (Александрова Е.В., Тоноян А.С., Сычев А.А., Крюкова К.К. Активность симпатоадреналовой системы в остром периоде тяжелой черепно-мозговой травмы: значение нейроанатомических факторов //Вестник РФФИ. 2016. № 2(90). С. 41-49)
Czura CJ, Tracey KJ. Autonomic neural regulation of immunity. J Intern Med. 2005; 257(2): 156-166
Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M. Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun. 1996; 10(2): 77-91
Starchenko AA. Clinical neuroimmunology of surgical diseases of the brain. St. Petersburg, 2001. 327 p. Russian (Старченко A.A. Клиническая нейроиммунология хирургических заболеваний головного мозга. СПб., 2001. 327 с.)
Kurbakov KM, Kosinets AN, Scrablo EI. Immunity state in neurosurgical patients with inflammatory complications. Bulletin of VGMU. 2008; 7: 3. Russian (Курбаков К.М., Косинец А.Н., Скребло Е.И. Состояние иммунитета у нейрохирургических больных с гнойно-воспалительными осложнениями //Вестник ВГМУ. 2008. № 7. С. 3)
Tyukavkina SY. The role of apoptosis in the formation of immunopathological processes that contribute to the development of infectious diseases. Immunology. 2013; 34(1): 52-57. Russian (Тюкавкина С.Ю. Роль апоптоза в формировании иммунопатологических процессов, способствующих развитию инфекционных заболеваний //Иммунология. 2013. Т. 34, № 1. С. 52-57)
Sanders VM, Baker RA, Ramer-Quinn DS, Kasprowicz DJ, Fuchs BA, Street NE. Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J Immunol. 1997; 158(9): 4200-4210
Rizoli SB, Jaja BN, Di Battista AP, Rhind SG, Neto AC, da Costa L et al. Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study. Crit Care. 2017; 21(1): 37