FEATURES LOCAL AND SYSTEMIC IMMUNE REGULATION IN CATARACT
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Abstract
The question of the inflammatory origin of the eye cataract remains open. To identify associative relationships between the severity of the cataract manifestations, complications after its surgical treatment and levels of proinflammatory and antiinflammatory cytokines in the anterior chamber of the eye and peripheral blood was examined 24 patients with uncomplicated presenile cataract of the eyes. The age of the patients was in the range of 28-55 years. The study group included 14 men and 10 women.
The concentration of interleukin 1 (IL-1b) receptor antagonist of interleukin 1 (IL-1Rα), interleukin-4 (IL-4), tumor necrosis factor alpha (TNF-α) and interferon alpha (INF-α) blood in the anterior chamber of the eye were measured by enzyme immunoassay. All patients were subjected to general analysis of blood and studied the concentrations of C-reactive protein (CRP) and circulating immune complexes (CIC) in peripheral blood.
The study showed that uncomplicated presenile cataract eye patients 28-55 years is a manifestation of disturbed immune regulation by proinflammatory and antiinflammatory cytokines. Based on violations of this regulation are constitutionally due to increased synthesis of TNF-α, defects in the reception of molecules of the family of IL-1, the imbalance in the synthesis of IL-4 and INF-α.
Cataract eyes and postoperative complications is positively associated with markers of systemic inflammatory response, concentrations in peripheral blood CRP, CIC, TNF-α.
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Simbirtsev AS. Cytokines as a new system, regulating body defense reactions. Cytokines and Inflammation. 2002; (1): 9-16. Russian (Симбирцев А.С. Цитокины - новая система регуляции защитных реакций организма // Цитокины и воспаление. 2002. № 1. С. 9-16)
Avetisova SE, Egorova EA, Moshetova LK, Neroeva VV, Takhchidi Kh.P, editors. Ophthalmology. National guidelines. Moscow: GEOTAR-Media Publ., 2018. 944 p. Russian (Офтальмология. Национальное руководство / под ред. С.Э. Аветисова, Е.А. Егорова, Л.К. Мошетовой, В.В. Нероева, Х.П. Тахчиди. М. : ГЭОТАР-Медиа, 2018. 944 с.)
Cytokines in clinical ophthalmology. Bikbov MM, Shevchuk NE, Malkhanov VB. Ufa: Ufa Research Institute of Eye Diseases, 2008. 87 p. Russian (Цитокины в клинической офтальмологии / М. М. Бикбов, Н. Е. Шевчук, В. Б. Мальханов. Уфа : Уфим. НИИ глазных болезней, 2008. 87 с.)
Kruglova ТB. Results and aspects of children with congenital cataracts treatment. In: Pediatric Ophthalmology: results and horizons: materials of scientific practical Conf., Moscow, 2006. p. 45-49. Russian (Круглова Т.Б. Итоги и перспективы лечения детей с врожденными катарактами // Детская офтальмология: итоги и перспективы: материалы науч.-практ. конф. Москва, 2006. С. 45-49.)
Burilov KB, Kostenev SV, Trunov AN. Evaluation of proinflammatory cytokines content in tear fluid after formation of the corneal valve with a mechanical microkeratome and a femtosecond human laser. Ophthalmic surgery. 2013; (4): P.34-37. Russian (Бурилов К.Б., Трунов А.Н. Оценка содержания провоспалительных цитокинов в слёзной жидкости после формирования роговичного клапана механическим микрокератомом и фемтосекундным лазером людей // Офтальмохирургия. 2013. № 4. С. 34-37.)
Abdullin RR. Substantiation of IOL implantation in early surgery of traumatic cataract. Cand. med. sci. abstracts diss. Ufa, 2004. 24 p. Russian (Абдуллин Р.Р. Обоснование имплантации ИОЛ в ранней хирургии травматической катаракты: автореф. дис. … канд. мед. наук. Уфа, 2004. 24 с.)
Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, et al. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes. Dev. 2006; 20: 1557-1562
Lakin GF. Biometrics. Moscow: High School, 1990. 352 p. Russian (Лакин Г. Ф. Биометрия : учеб.пособие для биол.спец.вузов-4-е изд., перераб и доп.– М. : Высшая школа, 1990. – 352 с.)
Yarilin AA. Immunology. Moscow, 2010. 752 p. (Ярилин А.А. Иммунология (учебник). М.: ГЭОТАР-Медиа, 2010. 752 с.