DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE HYPOGLYCEMIC SYNDROME

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CASE HISTORY
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2026-07-01

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Olga Ivanovna Mishchenko
Kuzbass Regional Clinical Hospital named after S.V. Belyaev, 650066, Oktyabrsky Av., 22
Daria Andreevna Borodkina
Kuzbass Regional Clinical Hospital named after S.V. Belyaev, 650066, Oktyabrsky Av., 22
Arina Vladimirovna Rubashko
Kemerovo State Medical University, 650056, Kemerovo, Voroshilova Str., 22a
Anastasia Sergeevna Kravchenko
Kemerovo State University, 650000, Kemerovo, Krasnaya Str., 6

Abstract

Autoimmune hypoglycemic syndrome (AHS) is a rare condition characterized by the development of hypoglycemia in the presence of autoantibodies to components of the glycemic regulation system. Despite its rarity, AHS poses a significant diagnostic challenge, often mimicking insulinomas or other causes of organic hyperinsulinism.
Hypoglycemic conditions remain one of the most challenging issues in clinical endocrinology. Autoimmune forms, combined in the concept of Autoimmune Hypoglycemic Syndrome (AHS), occupy a special place among the non-iatrogenic causes of hypoglycemia. AHS is considered a rare disease. Since its description in 1970, by the end of 1995, about 250 cases of this disease have been described worldwide.

Keywords

autoimmune hypoglycemic syndrome, Hirata syndrome, insulin autoantibodies, insulin receptor autoantibodies, hypoglycemia

Author Biographies

Olga Ivanovna Mishchenko,

candidate of medical sciences, head of the endocrinology department

Daria Andreevna Borodkina,

candidate of medical sciences, head of the regional endocrinology center

Arina Vladimirovna Rubashko,

clinical resident

Anastasia Sergeevna Kravchenko,

clinical resident

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
© Olga Ivanovna Mishchenko, Daria Andreevna Borodkina, Arina Vladimirovna Rubashko, Anastasia Sergeevna Kravchenko, 2026


Creative Commons License  This work is licensed under a Creative Commons Attribution 4.0 License.

How to Cite

Mishchenko, O. I., Borodkina, D. A., Rubashko, A. V., & Kravchenko, A. S. (2026). DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE HYPOGLYCEMIC SYNDROME. Medicine in Kuzbass, 25(2), 146-148. https://mednauki.ru/index.php/MK/article/view/1501

References

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