SCIENTIFIC JUSTIFICATION OF A COMPREHENSIVE PREVENTIVE STRATEGY TO REDUCE THE RISKS OF PREMATURE AGING IN THE ARCTIC ZONE
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Abstract
The development of the Arctic zone is associated with the complex impact of extreme natural and climatic and production factors, which have a synergistic effect, leading to the development of the phenomenon of accelerated «Arctic» aging. The hygienic regulation, which is carried out on a factor-by-factor basis, does not fully take into account the synergistic nature of the expected potential effects specific to the Arctic zone, which undoubtedly makes this research area relevant.
The purpose of the study is to provide a scientific basis for a set of preventive measures for nutritional correction in the Arctic zone, taking into account the specific features of nutrition and the molecular mechanisms of «Arctic» aging.
Materials and methods. A systematic literature review (30 sources, 2015-2025) and a 28-day experiment on 48 male Wistar rats were conducted. The animals were divided into 4 groups: intact control in comfortable conditions (K2), control in Arctic conditions (K1, temperature +4-6°C, «polar night» and «day» regimes), and two experimental groups in Arctic conditions, which received a specially developed vitamin and mineral complex «Arctic TROFI» in the doses recommended by the developers (E1) and 10-fold (E2). Physiological, biochemical, hormonal, hematological indicators and organ morphology were evaluated. The experiment was conducted in accordance with the principles of the European Convention for the Protection of Vertebrate Animals Used for Experimental Purposes (Strasbourg, 1986), and after approval by the institute's ethics committee.
Results and their discussion. Modeling of arctic conditions caused a stress reaction and signs of accelerated aging: hypothermia, hyperglycemia (an increase of 118%, p < 0.05), an increase in ALT/AST activity by 1.8-2.2 times, leukopenia, and structural damage to organs. An imbalance in the cortisol-testosterone system was detected (an increase in cortisol by 24%, and a decrease in testosterone by 31% in K1 compared to K2, p < 0.05). Nutritional correction had a dose-dependent protective effect: it normalized thermoregulation, reduced glucose and cytolysis levels, modulated hormonal status (decreased cortisol, increased testosterone), and reduced morphological damage.
Conclusion. It has been established that premature aging in the Arctic zone is caused by the synergism of extreme factors and micronutrient deficiencies. The experiment has confirmed the effectiveness of nutritional correction. The features of prevention based on the assessment of combined risks, mandatory micronutrient support, predictive monitoring, and personalization of measures have been scientifically substantiated. The implementation of this approach will ensure a transition to health management and the preservation of professional longevity in the Arctic.
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1. Provorova AA, Smirennikova EV, Ukhanova AV. Population health in the Russian Arctic: problems, challenges, solutions. Arctic and North. 2024; 55: 161-181. Russian (Проворова А.А., Смиреникова Е.В., Уханова А.В. Здоровье населения Российской Арктики: проблемы, вызовы, решения //Арктика и Север. 2024. № 55. С. 161-181.) doi: 10.37482/issn2221-2698.2024.55.161
2. Talykova LV, Bykov VR. Study of the effect of occupational exposure at the Arctic zone (literature review). Russian Arctic. 2021; 14(3): 41-53. Russian (Талыкова Л.В., Быков В.Р. Исследования эффектов влияния профессионального воздействия в Арктической зоне (обзор литературы) //Российская Арктика. 2021. Т. 14, № 3. С. 41-53.) doi: 10.24412/2658-4255-2021-3-00-04
3. Avdeeva VA, Suplotova LA, Pigarova EA, Rozhinskaya LY, Troshina EA. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin d deficiency and insufficiency in various geographic regions of the country. Problems of endocrinology. 2021; 67(2): 84-92. Russian (Авдеева В.А., Суплотова Л.А., Пигарова Е.А., Рожинская Л.Я., Трошина Е.А. Дефицит витамина D в России: первые результаты зарегистрированного, неинтервенционного исследования //Проблемы эндокринологии. 2021. Т. 67, № 2. С. 84-92.) doi: 10.14341/probl12736
4. Malavskaiya SI, Lebedev AV, Kostrova GN, Torshin IYU, Gromova OA. Associations between pathogenetic factors of metabolic and circulatory syndromes in young adults in a russian Arctic city. Human ecology. 2021; 2: 47-56. Russian (Малявская С.И., Лебедев А.В., Кострова Г.Н., Торшин И.Ю., Громова О.А. Взаимосвязь патогенетических факторов метаболического и циркуляторного синдромов у молодежи Арктики //Экология человека. 2021. № 2. С. 47-56.) doi: 10.33396/1728-0869-2021-2-47-56
5. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023; 186(2): 243-278. doi: 10.1016/j.cell.2022.11.001
6. Ilmarinen J. The ageing workforce – challenges for occupational health. Occup Med (Lond). 2006; 56(6): 362-364. doi: 10.1093/occmed/kql046
7. Nikiforova NA, Karapetyan TA, Dorshakova NV. Feeding habits of the northerners (literature review). Human ecology. 2018; 11: 20-22. Russian (Никифорова Н.А., Карапетян Т.А., Доршакова Н.В. Особенности питания жителей Севера (обзор литературы) //Экология человека. 2018. № 11. С. 20-22.) doi: 10.33396/1728-0869-2018-11-20-25
8. Istomin AV, Fedina IN, Shkurikhina SV, Kutakova NS. Nutrition and the north: hygienic problems of the arctic zone of russia (the review of the literature). Hygiene and sanitation, russian journal. 2018; 6: 557-563. Russian (Истомин А.В., Федина И.Н., Шкурихина С.В., Кутакова Н.С. Питание и север: гигиенические проблемы Арктической зоны России (обзор литературы) //Гигиена и санитария. 2018. № 6. С. 557-563.) doi: 10.18821/00169900-2018-97-6-557-563.
9. Berketova L, Korotkova D. Northern ethnic groups unusual dishes. Bulletin of science and practice. 2021; 7(2): 227-236. Russian (Беркетова Л.В., Короткова Д. Необычные блюда народов Севера //Бюллетень науки и практики. 2021. Т. 7, № 2. С. 227-236.) doi: 10.33619/2414-2948/63/22
10. Svetlichnaya TG, Vorobyeva NA. Lifestyle and self-percieved health of the nenets population living on the arctic island of vaigach. Human ecology. 2019; 12: 20-25. Russian (Светличная Т.Г., Воробьева Н.А. Образ жизни и здоровье ненцев в условиях постоянного островного проживания в Арктике //Экология человека. 2019. № 12. С. 20-25.) doi: 10.33396/1728-0869-2019-12-20-25
11. Shepeleva OA, Unguryanu TN, Degteva GN, Simonova NN, Novikova II. Dietary preferences of children in the nenets autonomous area considering ethnic affiliation. Human ecology. 2025; 32(6): 422-432. Russian (Шепелева О.А., Унгуряну Т.Н., Дегтева Г.Н., Симонова Н.Н., Новикова И.И. Пищевые предпочтения детей Ненецкого автономного округа с учетом этнической принадлежности //Экология человека. 2025. Т. 32, № 6. С. 422-432.) doi: 10.17816/humeco686494
12. Korchin VI, Korchina TYA, Ternikova EM, Bikbulatova LN, Lapenko VV. Influence of climatic and geographical factors of the yamalo-nenets autonomous okrug on the health of its population (review). Journal of medical and biological research. 2021; 9(1): 77-88. Russian (Корчин В.И., Корчина Т.Я., Терникова Е.М., Бикбулатова Л.Н., Лапенко В.В. Влияние климатогеографичеких факторов Ямало-Ненецкого автономного округа на здоровье населения (обзор) //Журнал медико-биологических исследований. 2021. Т. 9, № 1. С. 77-88.) doi: 10.37482/2687-1491-Z046
13. Antipova ON, Ivanov AN, Zlobina OV, Surovtseva KA, Ankina VD, Bondar GD, et al. Disorders of behavioral reactions of white male rats in modified photoperiodism. Contemporary Problems of Science and Education. 2019; 4: 62-72. Russian (Антипова О.Н., Иванов А.Н., Злобина О.В., Суровцева К.А., Анкина В.Д., Бондарь Г.Д., и др. Нарушение поведенческих реакций белых крыс-самцов в условиях измененного фотопериодизма //Современные проблемы науки и образования. 2019. № 4. С. 62-72.)
14. Antipova ON, Ivanov AN, ZIobina OV, Kirichuk VF, Surovtseva KA, Ankina VD, et al. Intense light deprivation as a factor in stress disorders of behavioral reactions and cognitive functions in the experiment. Saratov journal of medical scientific research. 2019; 4: 62-72. Russian (Антипова О.Н., Иванов А.Н., Злобина О.В., Киричук В.Ф., Суровцева К.А., Анкина В.Д., и др. Интенсивная световая депривация как фактор стрессорных нарушений поведенческих реакций и когнитивных функций в эксперименте //Саратовский научно-медицинский журнал. 2019. Т. 15, № 2. С. 363-368.)
15. Lushchak VI. Oxidative stress concept update: Free radicals, monitors, and effectors. Free Radic Biol Med. 2024; 213: 56-74.
16. Krivosheev VV, Kozlovskij IV, Nikitina LU. The effect of vitamin d deficiency on the morbidity and mortality of the Russian Federation northern territories population. Sanitary doctor. 2023; 4: 242-256. Russian (Кривошеев В.В., Козловский И.В., Никитина Л.Ю. Влияние дефицита витамина D на заболеваемость и смертность населения северных территорий России //Санитарный врач. 2023. № 4. С. 242-256.) doi: 10.33920/med-08-2304-05
17. Manella G, Asher G. The Circadian Nature of Mitochondrial Biology. Front Endocrinol (Lausanne). 2016; 7: 162. doi: 10.3389/fendo.2016.00162
18. Gakova EI, Gakova AA, Bessonova MI, Kayumova MM, Akimov AM, Petelina TI. Primary risk factors for cardiovascular diseases in men working on a rotational basis in the far north. Russian journal of preventive medicine and public health. 2022; 25(11): 61-67. Russian (Гакова Е.И., Гакова А.А., Бессонова М.И., Каюмова М.М., Акимов А.М., Петелина Т.И. Основные факторы риска развития сердечно-сосудистых заболеваний у мужчин, работающих вахтовым методом на Крайнем Севере //Профилактическая медицина. 2022. Т. 25, № 11. С. 61-67.) doi: 10.17116/profmed20222511161
19. Averyanova IV, Maximov AL,Vdovenko SI. Morphofunctional changes in long-time adaptation process observed in natives of intercontinental areas of Russia's northeast. Human ecology. 2015; 3: 12-19. Russian (Аверьянова И.В., Максимов А.Л., Вдовенко С.И. Морфофункциональные перестройки при длительных периодах адаптации у постоянных жителей внутриконтинентальной зоны Северо-Востока России //Экология человека. 2015. № 3. С. 12-19.)
20. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy – A Review. Nutrients. 2016; 8(2): 68. doi: 10.3390/nu8020068
21. MaydanVA, KuznetsovSM, LizunovVYU. Hygienic rationale for the adaptation of workers to the conditions of the far north. Russian military medical academy reports. 2020; 39(S3-3): 113-116. Russian (Майдан В.А., Кузнецов С.М., Лизунов В.Ю. Гигиеническое обоснование адаптации работников к условиям Крайнего Севера //Известия Российской военно-медицинской академии. 2020. Т. 39, № S3-3. С. 113-116.)
22. Traber MG, Stevens JF. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med. 2011; 51(5): 1000-1013. doi: 10.1016/J.Freeradbiomed.2011.05.017
23. Joseph JJ, Golden SH. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017; 1391(1): 20-34. doi: 10.1111/nyas.13217
24. Priego T, Martín AI, González-Hedström D, Granado M, López-Calderón A. Role of hormones in sarcopenia. Vitam Horm. 2021; 115: 535-570. doi: 10.1016/bs.vh.2020.12.021