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Abstract
In the context of the growth of non-communicable diseases, which are the leading cause of morbidity in the population, the importance of preventive approaches in healthcare is increasing. This article is devoted to the analysis of the role of personalized medicine and pharmacy as a strategic resource in the prevention of socially significant diseases such as oncological diseases. Modern achievements in the field of genomics, pharmacogenetics, digital technologies and pharmaceutical information are considered, contributing to the transition from a population-based model of healthcare to an individualized one. Based on the conducted research, the necessity of integrating personalized approaches in the field of healthcare and pharmaceutical provision is substantiated.
The aim of the study – to substantiate the role of personalized medicine and pharmacy as a strategic resource in the prevention of socially significant diseases, as well as to determine the conditions and directions for their effective implementation in domestic healthcare practice.
Materials and methods. The study uses a comprehensive interdisciplinary approach, including materials and methods: an analysis of scientific literature for the period 2015-2025 on the topics of personalized medicine, pharmacogenetics and cancer prevention; a systematic and comparative analysis of national and international programs for the introduction of personalized approaches to healthcare; a review of clinical recommendations and pharmacoeconomic studies on the use of personalized therapies in the treatment of socially significant diseases.
The results and their discussion. The scientific validity of the use of personalized approaches in the prevention of socially significant diseases has been confirmed. It has been shown that taking into account genetic markers can reduce the risk of adverse drug reactions by 30-50%. The key function of the pharmaceutical worker in the personalized pharmacy system has been identified, from the interpretation of pharmacogenetic testing data to the individual selection of drug therapy and monitoring of its effectiveness.
Conclusion. Personalized medicine and pharmacy are not only scientifically sound, but also socially and economically feasible directions in the prevention of socially significant diseases and should be considered as a strategic resource in building a sustainable and patient-oriented healthcare model of the future.
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Marketingovy`e issledovaniya po sovershenstvovaniyu lekarstvennogo obespecheniya naseleniya v regionax Rossii: kollektivnaya monografiya. Ufa: AE`TERNA, 2019. 303 s. Russian (Маркетинговые исследования по совершенствованию лекарственного обеспечения населения в регионах России: коллективная монография. Уфа: АЭТЕРНА, 2019. 303 с.) ISBN:978-5-00109-782-2
Petrov AG, Khoroshilova OV, Filimonov SN, Semenikhin VA. Methodological foundations of the organization of specialized pharmaceutical care for patients with socially significant diseases. Medicine in Kuzbass. 2025. 24(1): 77-82. Russian (Петров А.Г., Хорошилова О.В., Филимонов С.Н., Семенихин В.А Методологические основы организации специализированной фармацевтической помощи больным с социально значимыми заболеваниями //Медицина в Кузбассе. 2025. Т. 24, № 1. С. 77-82.) doi: 10.24412/2687-0053-2025-1-77-82
Kirshina IA, Soloninina AV, Katkova AD. Increase of compliance of chronic patients as aspects of pharmaceutical care. RUDN. Journal of Medicine. 2013; 6: 56-59. Russian (Кирщина И.А., Солонинина А.В., Каткова А.Д. Повышение комплаентности хронических больных как аспект фармацевтической помощи //Вестник РУДН. Серия: Медицина. 2013. № 6. С. 56-59)
Petrov AG, Khoroshilova OV, Filimonov SN, Panev NI, Semenikhin VA, Grigorieva EB. The relevance of the development of digital transformationin the system of pharmaceutical sanology in occupational diseases. Medicine in Kuzbass. 2024; 23(2): 11-20. Russian (Петров А.Г., Хорошилова О.В., Филимонов С.Н., Панев Н.И., Семенихин В.А., Григорьева Е.Б. //Актуальность развития цифровой трансформации в системе фармацевтической санологии при профессиональных заболеваниях //Медицина в Кузбассе. 2024. Т. 23, № 2. С. 11-20.) doi: 10.24412/2687-0053-2024-2-11-20
Sostoyanie onkologicheskoj pomoshhi naseleniyu Rossii v 2019 godu /pod red. A.D. Kaprina, V.V. Starinskogo, A.O. Shakhzadovoj M.: MNIOI im. P.A. Gercena − filial FGBU «NMICz radiologii» Minzdrava Rossii, 2020. 239 sRussian (Состояние онкологической помощи населению России в 2019 году /под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой М.: МНИОИ им. П.А. Герцена − филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2020. 239 с.) ISBN 978-5-85502-255-1
Gridelli С, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE. nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial. Drug Des Devel Ther. 2018; 12: 1445-1451. doi: 10.2147/DDDT.S155750
Stühlinger V. Health Technology Assessment (HTA) and Access Policies. Eur J Health Law. 2020; 27(3): 274-289. doi: 10.1163/15718093-BJA10006
Liu Q, Ramamoorthy A, Huang SM. Real-World data and clinical pharmacology: a regulatory science perspective. Clin Pharmacol Ther. 2019; 106(1): 67-71. doi: 10.1002/cpt.1413
Szymonik A. Logistics and Supply Chain Management. Lodz: Technical University of Lodz Press, 2012. 358 p.
Zhuravleva MV, Mudunov AM, Ulumbekova GE. Vector for personalized medicine: from implementation in to practice to expected results. HEALTHCARE MANAGEMENT: News, Views, Education. Bulletin of VSHOUZ. 2021; 7(4): 51-63. Russian (Журавлева М.В., Мудунов А.М., Улумбекова Г.Э. Вектор на персонализированную медицину: от внедрения в практику до ожидаемых результатов //ОРГЗДРАВ: новости, мнения, обучение. Вестник ВШОУЗ. 2021. Т. 7, № 4(26). С. 51-63.) doi: 10.33029/2411-8621-2021-7-4-51-63
Petrov AG, Khoroshilova OV, Semenikhin VA. Assessment and for ecasting of the riskof patientnon-compliance in the system of specialized pharmaceutical care for the population with oncological diseases. Medical and Pharmaceutical journal Pulse. 2024; 26(10): 195-204. Russian (Петров А.Г., Хорошилова О.В., Семенихин В.А. Оценка и прогнозирование риска пациентского нон-комплаенса в системе специализированной фармацевтической помощи населению с онкологическими заболеваниями //Медико-фармацевтический журнал Пульс. 2024. Т. 26, № 10. С. 195-204.) doi: 10.26787/nydha-2686-6838-2024-26-10-195-204
Morrissey KM, Marchand M, Patel H, Zhang R, Wu B, Chan HP, et al. Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting. Cancer Chemother Pharmacol. 2019; 84(6): 1257-1267. doi: 10.1007/s00280-019-03954-8
Vasyagina Yu.A. Izy`skanie putej sovershenstvovaniya obespecheniya lekarstvenny`mi sredstvami licz, imeyushhix pravo na l`goty`: avtoref. dis. … kand. farm. nauk. SPb., 2009. 24 s. Russian (Васягина Ю.А. Изыскание путей совершенствования обеспечения лекарственными средствами лиц, имеющих право на льготы: автореф. дис. … канд. фарм. наук. СПб., 2009. 24 с.)
Geller L.N. Teoreticheskie i organizacionno-e`konomicheskie osnovy` strategicheskogo upravleniya sistemoj farmacevticheskoj pomoshhi na urovne sub``ekta RF: avtoref. dis. ... doktora farm. nauk. M., 2007. 47s. Russian (Геллер Л.Н. Теоретические и организационно-экономические основы стратегического управления системой фармацевтической помощи на уровне субъекта РФ: автореф. дис. ... доктора фарм. наук. М., 2007. 47 с.)
Glembotskaya GT, Maskayeva AR. The concept of pharmaceutical care: realities and prospects. A new pharmacy. 2011; 5: 11-14. Russian (Глембоцкая Г.Т., Маскаева А.Р. Концепция фармацевтической помощи: реалии и перспективы //Новая аптека. 2011. № 5. С. 11-14)
Dremova NB, Ovod AI, Korzhavyh EA. Osnovy` farmacevticheskoj pomoshhi v zdravooxranenii: monografiya. Kursk: KGMU, 2009. 412 s. Russian (Дремова Н.Б., Овод А.И., Коржавых Э.А. Основы фармацевтической помощи в здравоохранении: монография. Курск: КГМУ, 2009. 412 с.)
Moshkova LV, Korzhavyh EA, Tretyakova EV. Rossijskie issledovaniya po upravleniyu i e`konomike farmacii (1991-2009 gg.): metodicheskoe posobie. M., 2010. 97 s. Russian (Мошкова Л.В., Коржавых Э.А., Третьякова Е.В. Российские исследования по управлению и экономике фармации (1991-2009 гг.): методическое пособие. М., 2010. 97 с.)
Soloninina AV. Normativno-pravovy`e aspekty` organizacii farmacevticheskoj deyatel`nosti: uchebnoe posobie. Perm, 2016. 164 s. Russian (Солонинина А.В. Нормативно-правовые аспекты организации фармацевтической деятельности: учебное пособие. Пермь, 2016. 164 с.)
