АССОЦИАЦИИ DAS-28 С ЛИПОПОЛИСАХАРИД-СВЯЗЫВАЮЩИМ БЕЛКОМ, sCD14 и ФАКТОРОМ РОСТА ЭНДОТЕЛИЯ СОСУДОВ ПРИ РЕВМАТОИДНОМ АРТРИТЕ

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Biomarkers such as sCD14, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), lipopolysaccharide-binding protein (LBP), and vascular endothelial growth factor (VEGF) have been implicated in RA pathogenesis and may inform disease activity and inflammation assessment.
This study aimed to evaluate the relationship between these biomarkers and RA disease activity, as measured by the Disease Activity Score 28 (DAS-28).
Materials and Methods. A total of 80 RA patients were enrolled and stratified according to DAS-28 scores into low and moderate disease activity groups. Serum levels of sCD14, RF, ACPA, LBP, and VEGF were measured using validated immunoassays. Statistical analyses included group comparisons correlation assessments and regression analysis between biomarker levels and DAS-28.
Results. sCD14, LBP, and VEGF concentrations were significantly elevated in patients with high disease activity (p < 0,05). RF and ACPA titers also positively correlated with the DAS-28 index (r = 0,233, p < 0,05). Multivariate analysis identified VEGF and LBP as independent predictors of RA activity, while sCD14 levels reflected systemic inflammation.
Discussion. The findings demonstrate that sCD14, LBP, and VEGF are associated with RA disease activity and may serve as informative biomarkers for monitoring inflammation and progression. RF and ACPA maintain relevance as established serological markers and correlate with activity indices.
Conclusion. sCD14, LBP, and VEGF, in conjunction with RF and ACPA, are valuable for evaluating RA disease activity and inflammatory burden. These biomarkers may aid in personalized disease management and improving outcome prediction.