SYSTEM FOR PREDICTING THE PROBABILITY OF DEVELOPING RESPIRATORY FAILURE IN CHRONIC MECHANIC BRONCHITIS
Main Article Content
Abstract
Subject. 433 workers of coal mines of the South of Kuzbass (drifters, stope miners, operators of rock removing machines) were examined at the age of 40 to 54 with a previously established diagnosis of chronic mechanic bronchitis.
Objective. To develop a system for predicting the probability of developing respiratory failure in the patients with chronic mechanic bronchitis based on the clinic-functional and genetic researches.
Methods. Clinical studies were carried out, the function of external respiration was studied; the body mass index, constitutional-morphological types (CMT) according to Rhys-Eysenck and Tanner, blood groups of AB0, Rhesus, MN systems, the level of C-reactive protein were determined.
Main results. During examination the signs of respiratory failure were revealed in 344 patients (79.4 %). Considering the high percentage of this complication, using the Bayes method we elaborated the system to predict the probability of developing respiratory failure in the patients with chronic mechanic bronchitis. The most significant markers of the risk of developing respiratory failure were revealed: the duration of the course of chronic bronchitis is 5 years and more, the presence of tobacco smoking, the body mass index is 30 and more, the hypersthenic CMT according to Rhys-Eysenck, andromorphic CMT according to Tanner, A(II), AB(IV), Rh-, NN blood groups, the increase in the level of C-reactive protein.
Scope of application. The system for predicting the probability of developing respiratory failure can be used during periodic medical examinations and in the rehabilitation of the patients with chronic mechanic bronchitis.
Conclusions. The system for predicting the probability of developing respiratory failure in the patients with chronic mechanic bronchitis has been elaborated, which makes it possible to raise the accuracy of predicting the respiratory failure by increasing the number of the factors analyzed using highly sensitive markers.Keywords
Author Biographies
Николай Иванович Панев,
candidate of medical sciences, chief of the occupational medicine departmentСергей Николаевич Филимонов,
Filimonov Sergey Nikolaevich
M.D., Ph.D., Professor. Chief.
Ольга Юрьевна Коротенко,
candidate of medical sciences, head of the department for functional and ultrasound diagnosticsРоман Николаевич Панев,
programmer, the laboratory for health protection of working populationНаталья Александровна Евсеева,
PhD student, the laboratory for health protection of working populationНаталия Яковлевна Панева,
junior research associate, the laboratory for health protection of working populationНаталья Александровна Ефименко,
doctor allergist-immunologist, head of the advisory department, clinic N 2Фаина Анисимовна Лузина,
candidate of biological sciences, senior research associate, the laboratory of population geneticsArticle Details
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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References
National guidelines. Occupational diseases of the respiratory system (Series of National Guidelines). Izmerov NF, Chuchalin AG, editors. M.: GEOTAR-Media Publ., 2015. 777 p. Russian (Национальное руководство. Профессиональные заболевания органов дыхания (Сер. Национальные руководства) /под ред. Н.Ф. Измерова, А.Г. Чучалина. М.: ГЭОТАР-Медиа, 2015. 777 с.)
Panev NI, Zakharenkov VV, Korotenko OYu, Epifantseva NN. Immune and cytokine mechanisms of the disorders of external respiration function in the miners with occupational dust pulmonary pathology. Occupational medicine and industrial ecology. 2015; (9): 109-110. Russian (Панев Н.И., Захаренков В.В., Коротенко О.Ю., Епифанцева Н.Н. Иммунные и цитокиновые механизмы нарушения функции внешнего дыхания у шахтеров с профессиональной пылевой патологией легких //Медицина труда и промышленная экология. 2015. № 9. С. 109-110)
Panev NI, Ambrosova MO, Korotenko OYu, Epifantseva NN, Mikhailova NN, Fomenko DV et al. Immune reactivity, cytokine status and external respiration function in occupational dust respiratory pathology in the workers of coal industry. In: The materials of Congress VI of pulmonologists in Siberia and the Far East (with international participation), Blagoveshchensk, May 27-28, 2015. Blagoveshchensk, 2015. P. 175-178. Russian (Панев Н.И., Амбросова М.О., Коротенко О.Ю., Епифанцева Н.Н., Михайлова Н.Н., Фоменко Д.В. и др. Иммунная реактивность, цитокиновый статус и функция внешнего дыхания при профессиональной пылевой патологии органов дыхания у работников угольной промышленности //Материалы VI Съезда врачей-пульмонологов Сибири и Дальнего Востока (с междунар. участием), Благовещенск, 27-28 мая 2015 г. Благовещенск, 2015. С. 175-178)
Panev NI, Zakharenkov VV, Ambrosova MO, Korotenko OYu, Epifantseva NN, Paneva NYa et al. Immune and cytokine mechanisms for formation of ventilation disorders in dust pulmonary pathology. Medical immunology. 2015; 17(S): 449. Russian (Панев Н.И., Захаренков В.В., Амбросова М.О., Коротенко О.Ю., Епифанцева Н.Н., Панева Н.Я. и др. Иммунные и цитокиновые механизмы формирования вентиляционных нарушений при пылевой патологии легких //Медицинская иммунология. 2015. Т. 17, № S. С. 449)
Stepashkin KN, Demko IV. Correlation of respiratory symptoms and lung function study data in railway workers. Bulletin of physiology and respiration pathology. 2012; (45): 38-42. Russian (Степашкин К.Н., Демко И.В. Взаимосвязь респираторных симптомов и данных исследования функции внешнего дыхания у работников железнодорожного транспорта //Бюллетень физиологии и патологии дыхания. 2012. № 45. С. 38-42)
Vasilyeva OS, Gusakov AA, Gushchina EE, Kravchenko NYu. Chronic obstructive pulmonary disease from exposure to industrial aerosols. Pulmonology. 2013; (3): 49-55. Russian (Васильева О.С., Гусаков А.А., Гущина Е.Е., Кравченко Н.Ю. Хроническая обструктивная болезнь легких от воздействия производственных аэрозолей //Пульмонология. 2013. № 3. С. 49-55)
Ignatova GL, Zakharova IA, Aleksandrovа EA. The dynamics of clinic and functional disturbances of the respiratory system depending on the age and smoking history. Bulletin of physiology and respiration pathology. 2013; (50): 19-22. Russian (Игнатова Г.Л., Захарова И.А., Александрова Е.А. Динамика клинических и функциональных нарушений дыхательной системы в зависимости от возраста и анамнеза курения //Бюллетень физиологии и патологии дыхания. 2013. № 50. С. 19-22)
Solovjova AV. Risk factors of pulmonary dysfunction in patients with a metabolic syndrome. Zemsky doctor. 2015; (1): 46-48. Russian (Соловьева А.В. Факторы риска нарушений функции внешнего дыхания у пациентов с метаболическим синдромом //Земский врач. 2015. № 1. С. 46-48)
Kuzmina OA, Afanasyev YuI, Churnosov MI, Grigorova SYu. Criteria for the risk of developing a bronchitis form of chronic obstructive pulmonary disease. Scientific bulletins of the Belgorod State University. 2013; 23(18): 79-83. Russian (Кузьмина О.А., Афанасьев Ю.И., Чурносов М.И., Григорова С.Ю. Критерии риска развития бронхитической формы хронической обструктивной болезни легких //Научные ведомости Белгородского государственного университета. 2013. Т. 23, № 18. С. 79-83)