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Сергей Федорович Гладков
Нина Константиновна Перевощикова
Наталья Степановна Черных

Abstract

As one of the most common dermatoses in children, atopic dermatitis (AD) is a multifactorial immune-mediated disorder caused by complex mechanisms of interaction between genetic and environmental factors. The dominant role in the formation of atopy, of course, belongs to the genetic component, but the leading trigger predictors invariably remain external environmental factors. The defining environmental component of atopy is infection, the delicate management of which makes it possible to control atopic march (AM). Current research emphasizes the potential of bacteriophages in modeling the gut microbiota of children in the first months of life, allowing very effective management of AM.

Keywords

atopic dermatitis, atopic march, gut microbiota, bacteriophages, decontamination, treatment, prevention

Author Biographies

Сергей Федорович Гладков,
doctor of allergology and immunology
Нина Константиновна Перевощикова,


Perevoshchikova Nina Konstantinovna
MD, PhD, professor

She is the Head of the Department of Pediatrics and Propedeutics of Children's Diseases, the Honoured Doctor of the Russian Federation.

All of her work is in close cooperation with practical health care. She gives consultations to more than 800 sick children in various hospitals of the city of Kemerovo and region. She developed new methods of diagnostics and treatment for children with chronic bronchial asthma, which helped to create the City Medical Center for Children and a kind of Asthma-school for children and their parents, that is based on the Children's Clinical Hospital №1.
Наталья Степановна Черных,
candidate of medical sciences, docent, docent of the department of polyclinic pediatrics, propaedeutics of childhood diseases and postgraduate training

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.

How to Cite

Гладков, С. Ф., Перевощикова, Н. К., & Черных, Н. С. (2024). EFFECT OF PHAGOTHERAPY IN A PATIENT WITH ATOPIC DERMATITIS: A CLINICAL CASE STUDY. Mother and Baby in Kuzbass, 25(4), 94-98. https://doi.org/10.24412/2686-7338-2024-4-94-98

References

Allergologiya i immunologiya /pod red. A.A. Baranova, L.S. Namazovoj-Baranovoj, R.M. Haitova. M.: Pediatr``, 2020. 512 s. Russian (Аллергология и иммунология /под ред. А.А. Баранова, Л.С. Намазовой-Барановой, Р.М. Хаитова. М.: ПедиатрЪ, 2020. 512 с.)

Krysanov IS, Krysanova VS, Karpov OI, Ermakova VYu. Social-economic burden of severe atopic dermatitis in the Russian Federation. Good Clinical Practice. 2019; (4): 4-14. Russian (Крысанов И.С., Крысанова В.С., Карпов О.И., Ермакова В.Ю. Экономическое бремя тяжелого атопического дерматита в Российской Федерации //Качественная клиническая практика. 2019. № 4. С. 4-14)

Matushevskaya EV, Komissarenko IA, Vladimirova EV, Konev YuV, Levchenko SV. A modern view of the atopic dermatitis treatment from the position of dermatologist and gastroenterologist. Russian Journal of Clinical Dermatology and Venereology. 2021; 20(1): 104-108. Russian (Матушевская Е.В., Комиссаренко И.А., Владимирова Е.В., Конев Ю.В., Левченко С.В. Современный взгляд на лечение атопического дерматита с позиции дерматолога и гастроэнтеролога //Клиническая дерматология и венерология. 2021. Т. 20, № 1. С. 104‑108.) doi: 10.17116/klinderma202120011104

Tamrazova OB, Stadnikova AS, Novik GA, Taganov AV, Bagramova GE, Goncharova LV. Atopic dermatitis. Differentiated approach to the management of patients taking into account phenotypes. Pediatrician Practice. 2023; 1: 13-22. Russian (Тамразова О.Б., Стадникова А.С., Новик Г.А., Таганов А.В., Баграмова Г.Э., Гончарова Л.В. Атопический дерматит. Дифференцированный подход к ведению пациентов с учетом фенотипов //Практика педиатра. 2023. № 1. С. 13-22)

Smolkin YS, Balabolkin II, Gorlanov IA, Kruglova LS, Kudryavtseva AV, Meshkova RY, et al. Consensus document APAIR: Atopic dermatitis in children – update 2019 (short version) Part 1. Allergology and Immunology in pediatrics. 2020; 2(61): 4-25. Russian (Смолкин Ю.С., Балаболкин И.И., Горланов И.А., Круглова Л.С., Кудрявцева А.В., Мешкова Р.Я., и др. Согласительный документ АДАИР: Атопический дерматит у детей – обновление 2019 (краткая версия) Часть 1 //Аллергология и иммунология в педиатрии. 2020. № 2(61). С. 4-25.) doi: 10.24411/2500-1175-2020-10001

Kashinskaya TS, Shakhova NV. Correlation between specific immunoglobulins E to allergens and enterotoxins of staphylococcus aureus and atopic dermatitis severity in children aged from 3 to 6 years. Russian Pediatric Journal. 2022; 3(1): 139. Russian (Кашинская Т.С., Шахова Н.В. Ассоциация уровня специфических иммуноглобулинов Е к аллергенам и энтеротоксинам золотистого стафилококка со степенью тяжести атопического дерматита у детей 3-6 лет //Российский педиатрический журнал. 2022. № 3(1). С. 139)

Yu R, Ma Y, Luo Z, Qi C, Xie A, Jiang Y, et al. Maternal supplementation with Limosilactobacillus reuteri FN041 for preventing infants with atopic dermatitis: study protocol for a randomized controlled trial. Front Microbiol. 2023; 14: 1267448. doi: 10.3389/fmicb.2023.1267448

Abrahamsson TR, Jakobsson HE, Andersson AF, Bjorksten B, Engstrand L, Jenmalm MC. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012; 129(2): 434-440, 440e1-2. doi: 10.1016/j.jaci.2011.10.025

Deng WY, Chen WJ, Zhong HJ, Wu LH, He XX. Washed microbiota transplantation: a case report of clinical success with skin and gut microbiota improvement in an adolescent boy with atopic dermatitis. Front Immunol. 2023; 14: 1275427. doi: 10.3389/fimmu.2023.1275427

Turroni F, Milani C, Duranti S, Lugli GA, Bernasconi S, Margolles A, et al. The infant gut microbiome as a microbial organ influencing host well-being. Ital J Pediatr. 2020; 46(1): 16. doi: 10.1186/s13052-020-0781-0

Lee KH, Song Y, Wu W, Yu K, Zhang G. The gut microbiota, environmental factors, and links to the development of food allergy. Clin Mol Allergy. 2020: 18: 5. doi: 10.1186/s12948-020-00120-x

Fujimura K, Sitarik A, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016; 22(10): 1187-1191. doi: 10.1038/nm.4176

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