Main Article Content
Abstract
Due to the high risk of developing chronic non-infectious diseases while taking artificial sweeteners, there is a need to search for alternative, safer sugar substitutes of natural origin. One such option now is plant proteins found in tropical plants that have a sweet taste – «sweet proteins» or natural peptide sweeteners (NPSS). Sweet proteins (SP) are protein molecules that have a sweet taste hundreds and thousands of times higher than sucrose, they are low in calories and do not cause significant changes in blood sugar levels. In addition, SB, being a protein structure, is completely processed by the body and accordingly has significant nutritional value. The most studied SBs include:thaumatin, brazzein, monellin, curculin, miraculin, mabinlin, pentadin, the safety, dosage and toxicity of which are currently being discussed.
Accumulating knowledge about the varieties of sweet proteins, their structure, properties and effects, including anti-inflammatory, anti-allergenic, anti-tumor and antioxidant, will make it possible to build prospects for their use in the prevention of chronic non-infectious diseases.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Tordoff MG. How do non-nutritive sweeteners increase food intake? Appetite. 1988; 11(1): 5-11
Zafra MA, Molina F, Puerto A. The neural/ cephalic phase reflexes in the physiology of nutrition. Neurosci Biobehav Rev. 2006; 30(7): 1032-1044. doi: 10.1016/j.neubiorev.2006.03.005
Blanco-Gandia MC, Montagud-Romero S, Rodríguez-Arias M. Binge eating and psychostimulant addiction. World J Psychiatry. 2021; 11(9): 517-529. doi: 10.5498/wjp.v11.i9.517
Beauchamp GK, Moran M. Acceptance of sweet and salty tastes in 2-year-old children. Appetite. 1984; 5(4): 291-305. doi: 10.1016/s0195-6663(84)80002-1
Razina AO, Runenko SD, Achkasov EE. Obesity: Current Global and Russian Trends. Annals of the Russian Academy of Medical Sciences. 2016; 71(2): 154-159. Russian (Разина А.О., Руненко С.Д., Ачкасов Е.Е. Проблема ожирения: современные тенденции в России и в мире //Вестник РАМН. 2016. Т. 71, № 2. С. 154-159.) doi: 10.15690/vramn655
Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 2017; 189(28): E929-E939. doi: 10.1503/cmaj.161390
Proekt Rospotrebnadzora «Zdorovoe pitanie», razdel stati: Sladosti: davat nelzya otbirat. Russian (Проект Роспотребнадзора «Здоровое питание», раздел статьи: Сладости: давать нельзя отбирать.) URL: https://xn----8sbehgcimb3cfabqj3b.xn--p1ai/healthy-nutrition/news/sladosti-davat-nelzya-otbirat/ 27.12.2023. (Дата обращения: 28.05.2024)
Dolce vita; sakharnaya otrasl Rossii v 2022 godu. Analiticheskii obzor. NRA, 2022. Russian (Dolce vita; сахарная отрасль России в 2022 году. Аналитический обзор. НРА, 2022.) URL: https://www.ranational.ru/sites/default/files/Sugar_062022.pdf (Дата обращения: 28.05.2024)
Alferova VI, Mustafina SV. Prevalence of obesity in the adult population of the Russian Federation (literature review). Obesity and metabolism. 2022; 19(1): 96-105. Russian (Алфёрова В.И., Мустафина С.В. Распространенность ожирения во взрослой популяции Российской Федерации (обзор литературы) //Ожирение и метаболизм. 2022. Т. 19, № 1. С. 96-105.) doi: 10.14341/omet12809
Paglia L. The sweet danger of added sugars. Eur J Paediatr Dent. 2019; 20(2): 89. doi: 10.23804/ejpd.2019.20.02.01
Egorova IA, Komarova SG. About the benefits and dangers of sugar substitutes. Advances in chemistry and chemical technology. 2015; 2(161): 51-53. Russian (Егорова И.А., Комарова С.Г. О пользе и вреде сахарозаменителей //Успехи в химии и химической технологии. 2015. № 2(161). С. 51-53)
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C.A, Maza O, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514(7521): 181-186. doi: 10.1038/nature13793
Vanamala JK, Knight R, Spector TD. Can Your Microbiome Tell You What to Eat? Cell Metabolism. 2015; 22(6): 960-1. doi: 10.1016/j.cmet.2015.11.009
Thaiss CA, Itav S, Rothschild D, Meijer MT, Levy M, Moresi C, et al. Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature. 2016; 540(7634): 544-551. doi: 10.1038/nature20796
Zhang N, Ju Z, Zuo T. Time for food: The impact of diet on gut microbiota and human health. Nutrition. 2018; 51-52: 80-85. doi: 10.1016/j.nut.2017.12.005
Debras C, Chazelas E, Sellem L, Porcher R, Druesne-Pecollo N, Esseddik Y, et al. Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort. BMJ. 2022; 378: e071204. doi: 10.1136/bmj-2022-071204
Boles RE, Gunnarsdottir T. Family meals protect against obesity: exploring the mechanisms. J Pediatr. 2015; 166(2): 220-221. doi: 10.1016/j.jpeds.2014.10.034
Zhao X, Wang C, Zheng Y, Liu B. New Insight into the Structure-Activity Relationship of Sweet-Tasting Proteins: Protein Sector and Its Role for Sweet Properties. Front Nutr. 2021; 8: 691368. doi: 10.3389/fnut.2021.691368
Kroger M, Meister K, Kava R. Low calorie sweeteners and other sugar substitutes: a review of the safety issues. Comprehensive Reviews in Food Science and Food Safety. 2006; 5(2): 35-47. doi: 10.1111/j.1541-4337.2006.tb00081.x
Hung CY, Cheng LH, Yeh CM. Functional expression of recombinant sweet-tasting protein brazzein by Escherichia coli and Bacillus licheniformis. Food Biotechnology. 2019; 33(3): 251-271. doi: 10.1080/08905436.2019.1618323
Cereghino JL, Cregg JM. Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol Rev. 2000; 24(1): 45-66. doi: 10.1111/j.1574-6976.2000.tb00532.x
Faus I. Recent developments in the characterization and biotechnological production of sweet-tasting proteins. Appl Microbiol Biotechnol. 2000; 53(2): 145-151. doi: 10.1007/s002530050001
Xiaoda S, Yuting Y, Li L, Mengjiao H, Siwei D, Hong T, et al. Design and development of a high temperature stable sweet protein base on monellin, Process Biochemistry. 2020; 89: 29-36. doi: 10.1016/j.procbio.2019.07.011
Farag MA, Rezk MM, HamdiElashal M, El-Araby M, Khalifa SAM, El-Seedi HR. An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety. Food Res Int. 2022; 162(1): 111853. doi: 10.1016/j.foodres.2022.111853
Lynch B, Wang T, Vo T, Tafazoli S, Ryder J. Safety evaluation of oubli fruit sweet protein (brazzein) derived from K omagataella phaffii, intended for use as a sweetener in food and beverages. Toxicology research and application. 2023; 7(1): 1-21. doi: 10.1177/23978473231151258
Poursalim M, Shasaltaneh MD, Jafarian V, Salehabadi H. The novel anti-cancer feature of Brazzein through activating of hTLR5 by integration of biological evaluation: molecular docking and molecular dynamics simulation. Scientific Reports. 2022; 12: 21979. doi: 10.1038/s41598-022-26487-2
Novik TS, Koveshnikova EI, Kotlobay AA, Sycheva LP, Kurochkina KG, Averina OA, et al. Sweet-Tasting Natural Proteins Brazzein and Monellin: Safe Sugar Substitutes for the Food Industry. Foods. 2023; 12(22): 4065. doi: 10.3390/foods12224065
Markova EV, Leonova EI, Sopova YuV. Sweet protein brazzein is a promising sweetener. Problems of Nutrition. 2024; 93(1): 61-71. DOI: 10.33029/0042-8833-2024-93-1-61-71. Russian (Маркова Е.В., Леонова Е.И., Сопова Ю.В. Сладкий белок браззеин как перспективный подсластитель //Вопросы питания. 2024. Т. 93, № 1. С. 61-71.) doi: 10.33029/0042-8833-2024-93-1-61-71
Theerasilp S, Kurihara Y. Complete purification and characterization of the taste-modifying protein, miraculin, from miracle fruit. J Biol Chem. 1988; 263(23): 11536-11539. doi: 10.1016/S0021-9258(18)37991-2
López-Plaza B, Gil Á, Menéndez-Rey A, Bensadon-Naeder L, Hummel T, Feliú-Batlle J, Palma-Milla S. Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol. Nutrients. 2023; 15(21): 4639. doi: 10.3390/nu15214639
Liu X, Maeda S, Hu Z, Aiuchi T, Nakaya K, Kurihara Y. Purification, complete amino acid sequence and structural characterization of the heat-stable sweet protein, mabinlin II. Eur J Biochem. 1993; 211(1-2): 281-287. doi: 10.1111/j.1432-1033.1993.tb19896.x
Yamashita H, Theerasilp S, Aiuchi T, Nakaya K, Nakamura Y, Kurihara Y. Purification and complete amino acid sequence of a new type of sweet protein taste-modifying activity, curculin. J Biol Chem. 1990; 265(26): 15770-15775
Okubo S, Terauchi K, Okada S, Saito Y, Yamaura T, Misaka T, et al. De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits. BMC Genomics. 2021; 22(1): 347. doi: 10.1186/s12864-021-07674-3
Sharififar F, Ashrafzadeh A, Khanaman MK. A Review of Natural Peptide Sweeteners. International Journal of Peptide Research and Therapeutics. 2022; 28, 158. doi: 10.1007/s10989-022-10464-4
Ming D, Hellekant G. Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B. FEBS Lett. 1994; 355(1): 106-108. doi: 10.1016/0014-5793(94)01184-2
Hellekant G, Danilova V. Brazzein a small, sweet protein: discovery and physiological overview. Chem Senses. 2005; 30(1): i88-89. doi: 10.1093/chemse/bjh127
Saraiva A, Carrascosa C, Ramos F, Raheem D, Pedreiro S, Vega A, Raposo A. Brazzein and Monellin: Chemical Analysis, Food Industry Applications, Safety and Quality Control, Nutritional Profile and Health Impacts. Foods. 2023; 12(10): 1943. doi: 10.3390/foods12101943
Neiers F, Belloir C, Poirier N, Naumer C, Krohn M, Briand L. Comparison of Different Signal Peptides for the Efficient Secretion of the Sweet-Tasting Plant Protein Brazzein in Pichia pastoris. Life (Basel). 2021; 11(1): 46. doi: 10.3390/life11010046
, Kinghorn AD, Kaneda N, Baek NI, Kennelly EJ, Soejarto DD. Noncariogenic intense natural sweeteners. Med Res Rev. 1998; 18(5): 347-360. doi: 10.3390/life11010046
Joseph JA, Akkermans S, Nimmegeers P, Van Impe JFM. Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives. Front Microbiol. 2019; 10: 695. doi: 10.3389/fmicb.2019.00695
O'Brien-Nabors L. Alternative Sweeteners (4th ed.). CRC Press. 2012; 587 р. doi: 10.1201/b11242
Kim NC, Kinghorn AD. Highly sweet compounds of plant origin. Arch Pharm Res. 2002; 25(6): 725-746. doi: 10.1007/BF02976987