A METHOD OF MODELING ASEPTIC NECROSIS OF THE FEMORAL HEAD
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Abstract
Osteochondropathy of the femoral head is an important medical and social problem in consequence of the high cost of treatment and the risk of disability. To study this pathology and approbation of new methods of treatment it is necessary to create a simple and reliable biological model. Existing methods of modeling are time-consuming, caused with high risk of complications and caused suffering to lab animals. The drawback of existing models is a partial reproduction of the pathogenesis of osteochondropathy of the femoral head.
The purpose of the study – the development of technically simple, reliable, minimally invasive way of getting aseptic necrosis of the femoral head in laboratory animals.
Material and methods. To simulate two key components of pathogenesis – vascular and load, is the introduction into the tissues of the hip joint of a 0,5 % solution of epinephrine in combination with physical load.Keywords
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Conzemius MG, Brown TD, Zhang Y, Robinson RA. A new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure. Journal of Orthopaedic Research. 2002; (20): 303-309
Kim HK, Su PH. Development of flattening and apparent fragmentation following ischemic necrosis of the capital femoral epiphysis in a piglet model. J. Bone Joint Surg Am. 2002; 84 (8): 1329-1334
Kirgizov IV, Gorbunov NP, Kirpichev SV et al. Method of creating a model osteochondropathy of the femoral head. RU Patent No. 2229167 from 18.10.2004. Russian (Киргизов И.В., Горбунов Н.С., Кирпичев С.В. и соавт. Способ создания модели остеохондропатии головки бедренной кости. Патент РФ № 2229167 от 18.10.2004.)
Kirpichev SV. Influence of the value of intraosseous pressure in the femoral head on the formation and choice of surgical treatment of Perthes disease: abstract dis. cand. of medical sciences. Krasnoyarsk, 2008. 26 p. Russian (Кирпичев С.В. Влияние величины внутрикостного давления в головке бедренной кости на формирование и выбор хирургического лечения болезни Пертеса: автореф. дис. … канд. мед. наук, Красноярск, 2008. 26 c.)
Tatianchenko VK, Ovsyannikov AV, Sikilinda VD et al. Method of modeling aseptic femoral head osteonecrosis. RU Patent No. 2069015 from 10.11.1996. Russian (Татьянченко В.К., Овсянников А.В., Сикилинда В.Д. и соавт. «Способ моделирования асептического некроза головки бедренной кости». Патент РФ № 2069015 от 10.11.1996.)
Rasulov RM, Kornilov NV, Bolshakov OP. A method of modeling aseptic femoral head necrosis in laboratory animals. RU Patent No. 2354313 from 10.05.09. Russian (Расулов Р.М., Корнилов Н.В., Большаков О.П. Способ моделирования асептического некроза головки бедренной кости на лабораторных животных. Патент РФ № 2354313 от 10.05.09.)
Pozharsky VP, Egorova SA, Egorov NA et al. Method of modeling the epiphyseal avascular necrosis in the experiment. RU Patent No. 2300812 from 10.06.07. Russian (Пожарский В.П., Егорова С.А., Егоров Н.А. и соавт. Способ моделирования эпифизарного асептического некроза в эксперименте. Патент РФ № 2300812 от 10.06.07.)
Boyko AS. Comprehensive treatment of the disease Legg-calve-Perthes in children: abstract dis. cand. of medical sciences. Rostov-na-donu, 2006. 24 p. Russian (Бойко А.С. Комплексное лечение болезни Легг-Кальве-Пертеса у детей: автореф. дис. … канд. мед. наук. Ростов-на-Дону, 2006. 24 с.)
Netyl'ko GI, Bozhko AM, Zaitsev MYu et al. Method of creating a model of osteoporosis in the rabbit in the experiment. RU Patent No. 2480843 from 27.04.2013. Russian (Нетылько Г.И., Божко А.М., Зайцева М.Ю. и соавт. Способ создания модели остеопороза у кролика в эксперименте. Патент РФ № 2480843 от 27.04.2013.)
Berenstein SS. Method of modeling aseptic femoral head osteonecrosis. RF Patent No. 2009547 from 15.03.1994. Russian (Беренштейн С.С. Способ моделирования асептического некроза головки бедренной кости. Патент РФ № 2009547 от 15.03.1994.)