EFFICIENCY OF OBESITY TREATMENT IN INFERTILE WOMEN OF REPRODUCTIVE AGE USING ORLISTAT
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Abstract
Objective – to evaluate the dynamics of anthropometric indices, hormonal and metabolic indices in infertile women of reproductive age with obesity during the treatment with orlistat.
Materials and methods. The study included 30 infertile women of reproductive age with obesity. All patients were prescribed a low-calorie diet (1200 kcal) and orlistat at a dose of 360 mg/day. Anthropometric study, the determination of the hormonal and metabolic levels were carried out before the start of treatment and 12 months later.
Results. A decrease in body weight was registered in 18 (60 %) patients from 5 to 21 kg, on average, by 10.42 ± 3.89 kg, respectively, there was a decrease in BMI from 36.77 ± 3.01 to 32.73 ± 3, 02 (p < 0.001). As a result of the treatment in patients, the level of fasting glucose, insulin resistance, the level of cholesterol, TG, cholesterol-LDL, Ka, and statistically significant increase in cholesterol-HDL cholesterol significantly decreased. After obesity treatment, a statistically significant decrease in the level of LH, LH / FSH, IRI, E1 and, conversely, an increase in the level of FSH was detected. In addition, almost 2-fold increase in the level of progesterone was registered (p = 0.020). The frequency of menstrual irregularities decreased from 66.7 % women to 16.6 % (p = 0.007). Desired pregnancy within a year occurred in one patient.
Conclusion. In infertile patients of reproductive age with obesity, the use of orlistat in combination with a low-calorie diet for 12 months is an effective option in restoring metabolic processes, reducing body weight and restoring menstrual and reproductive function.
Keywords
Author Biographies
Ольга Анатольевна Тачкова,
candidate of medical sciences, docent, department of hospital therapy and clinical pharmacologyНаталья Владимировна Артымук,
Artymuk Natalia Vladimirovna
MD, PhD, professor, deputy editor of the journal Mother and Baby in Kuzbass.
She is the Head of the Department of Obstetrics and Gynaecology №2, the Deputy Editor-in-Chief. She is also the President of the Kemerovo regional public organization “Association of obstetricians and gynecologists”, the chief obstetrician-gynecologist of the Siberian Federal district; the member of the Board of the Russian Society of Obstetricians and Gynaecologists, the member of the European Society of Contraception and Reproductive Health, the European Society of Gynaecological Oncology and the International Society of Gynecological Endocrinology.
She has graduated from Kemerovo State Medical institute with honors. She studied in clinical residency in obstetrics and gynecology at School of Arenberg (Salzburg, Austria) and School of Bloomberg (Johns Hopkins University, Baltimore, USA). One is a specialist in ultrasound diagnostics in obstetrics and gynecology, endocrinology and endoscopic surgery. In 1996 in Barnaul she defended her PhD thesis and her doctoral thesis in 2003 in Moscow.
Her priorities are: endocrine gynecology, infertility, cervix uteri pathology, menopausal disorders, disorder of menstrual function, endoscopic and abdominal gynecological surgery.
She deals with reproductive health problems, non-surgical and surgical treatment of benign neoplasms of genital organs. She is an author of more than 450 scientific works, including 3 monographs and study manuals for doctors. She has her highest medical qualification category in “Obstetrics and gynecology”.
Наталья Александровна Сухова,
candidate of medical sciences, docent, department of hospital therapy and clinical pharmacologyArticle Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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