DIABETIC FETOPATHY – PATHOGENESIS, PROGNOSIS, PERINATAL AND NEONATAL OUTCOMES
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Abstract
The aim of the research – to carry out an analytical review of modern sources of scientific literature, covering pathogenesis, prognosis, perinatal and neonatal outcomes in diabetic fetopathy.
Materials and methods. The analysis of 50 domestic and foreign sources of literature on this topic.
Results. Based on the results of the analysis of scientific data, the understanding of the etiology and pathogenesis of diabetic fetopathy has been updated. The review describes possible clinical manifestations, perinatal and neonatal complications associated with diabetic fetopathy.
Conclusion. Diabetic fetopathy is associated with a risk of perinatal and neonatal complications, which makes it an urgent problem. The analysis shows that this pathology requires further study.
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
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References
Rozhkova OV, Remneva OV. Gestational diabetes mellitus: obstetric and perinatal outcomes (literature review). ENI Trans-Baikal Medical Bulletin. 2018; 3: 127-142. Russian (Рожкова О.В., Ремнева О.В. Гестационный сахарный диабет: акушерские и перинатальные исходы (обзор литературы) //ЭНИ Забайкальский медицинский вестник. 2018. № 3. С. 127-142)
Chen Y, Quick WW, Yang W, Zhang Y, Baldwin A et al. Cost of gestational diabetes mellitus in the United States in 2007. Popul Health Manag. 2009. 12. 165-74. doi: 10.1089/pop.2009.12303
Dedov II, Krasnopolsky VI, Sukhikh GT. Russian national consensus «Gestational diabetes mellitus: diagnosis, treatment, postpartum monitoring». Diabetes. 2012; 4: 4-10. Russian (Дедов И.И., Краснопольский В.И., Сухих Г.Т. Российский национальный консенсус «Гестационный сахарный диабет: диагностика, лечение, послеродовое наблюдение» //Сахарный диабет. 2012. № 4. С. 4-10)
Eades CE, Cameron DM, Evans JMM. Prevalence of gestational diabetes mellitus in Europe: A meta-analysis. Diabetes Res Clin Pract. 2017; 129: 173-181. doi: 10.1016/j.diabres.2017.03.030
Shen Y, Hou L, Liu H, Wang L, Leng J, Li W, Hu G. Racial differences of incident diabetes postpartum in women with a history of gestational diabetes. Diabetes. 2019. 20: 107472. doi: 10.1016/j.jdiacomp.2019.107472
Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy. WHO, 2013. 63
Burumkulova FF, Troickaya MV, Petruhin VA, Bashakin NF, Aksenov AN, Kotov YB The diabetic embriopathy and perinatal pathology under pregnancy complicated by gestational diabetes mellitus. Lechenie i profilaktika. 2013; 2(6): 125-132. Russian (Бурумкулова Ф.Ф., Троицкая М.В., Петрухин В.А., Башакин Н.Ф., Аксенов А.Н., Котов Ю.Б. Диабетическая фетопатия и перинатальная патология при беременности, осложненной гестационным сахарным диабетом //Лечение и профилактика. 2013. № 2(6). С. 125-132)
Kautzky-Willer A, Harreiter J, Winhofer-Stöckl Y, Bancher-Todesca D, Berger A, Repa A et al. Gestationsdiabetes (GDM) (Update 2019). Wiener klinische Wochenschrift. 2019; 131(Suppl 1): 91-102. doi: 10.1007/s00508-018-1419-8
Gauster M, Desoye G, Tötsch M, Hiden U. The placenta and gestational diabetes mellitus. Curr Diab Rep. 2012; 12(1): 16-23. doi: 10.1007/s11892-011-0244-5
Kharitonova LA, Papysheva OV, Kataysh GA, Yudina TM, Bogomaz DS. The state of health of children born to mothers with diabetes mellitus. Russian Bulletin of perinatology and pediatrics. 2018; 63: (3): 26-31. Russian (Харитонова Л.А., Папышева О.В., Катайш Г.А., Юдина Т.М., Богомаз Д.С. Состояние здоровья детей, рожденных от матерей с сахарным диабетом //Российский вестник перинатологии и педиатрии. 2018. Т. 63, № 3. С. 26-31)
Kautzky-Willer A, Harreiter J, Winhofer-Stöckl Y, Weitgasser R, Lechleitner M. Clinical practice recommendations for diabetes in pregnancy. Wien Klin Wochenschr. 2019; 131(Suppl 1): 103-109. doi: 10.1007/s00508-019-1456-y
Li HP, Chen X, Li MQ. Gestational diabetes induces chronic hypoxia stress and excessive inflammatory response in murine placenta. Int J Clin Exp Pathol. 2013; 6(4): 650-659
Meiramova A, Ainabekova B, Sadybekova G, Akhmetova Z., Imangazinova S., Omralina1 Y. Peculiarities of the course of gestation and pregnancy outcomes in women with gestational diabetes mellitus. Acta Endocrinol (Buchar). 2018; 14(2): 213-218. doi: 10.4183/aeb.2018.213
Saad MI, Abdelkhalek TM, Saleh MM, Haiba MM, Tawfik SH, Kamel MA. Maternal diabetes impairs oxidative and inflammatory response in murine placenta. Springer Plus. 2016; 5: 532. doi: 10.1186/s40064-016-2180-y
Schäfer-Graf UM, Wöckel A. Severe diabetic fetopathy due to undiagnosed gestational diabetes mellitus. Dtsch Med Wochenschr. 2006; 131(20): 1151-1154
Al-Matubsi HY, Salim MD, El-Sharaky AS, Kamel MA, Oriquat GA, Helmy MH, et al. Activities of cyclooxygenases, and levels of prostaglandins E2 and F2alpha, in fetopathy associated with experimental diabetic gestation. Diabetes Metab. 2010; 36(1): 43-50. doi: 10.1016/j.diabet.2009.06.009
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M, et al. Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy. Gynecol Endocrinol. 2016; 32(7): 548-552. doi: 10.3109/09513590.2016.1138461
Tantbirojn P, Taweevisit M, Sritippayawan S, Uerpairojkit B. Diabetic fetopathy associated with bilateral adrenal hyperplasia and ambiguous genitalia: a case report. J Med Case Reports. 2008; 2: 251. doi: 10.1186/1752-1947-2-251
Mitanchez D. Fetal and neonatal complications of gestational diabetes: perinatal mortality, congenital malformations, macrosomia, shoulder dystocia, birth injuries, neonatal outcomes. J Gynecol Obstet Biol Reprod (Paris). 2010; 39(8 Suppl 2): S189-99. doi: 10.1016/S0368-2315(10)70046-6
Petruhin VA, Burumkulova FF. Gestation diabetes mellitus. V.F.Snegirev Archives of Obstetrics and Gynecology. 2014; 1(1): 48-51. Russian (Петрухин В.А., Бурумкулова М.В. Гестационный сахарный диабет //Архив акушерства и гинекологии им. В.Ф. Снегирева. 2014. Т. 1, № 1. С. 48-51)
Kilina AV, Kolesnikova MB. Antenatal development and adaptation period of infants born by mothers with gestational diabetes. Current Pediatrics. 2008; 7(2): 111-113. Russian (Килина А.В., Колесникова М.В. Антенатальное развитие и течение адаптационного периода новорожденных, родившихся у матерей с гестационным сахарным диабетом //Вопросы современной педиатрии. 2008. Т. 7, № 2. С. 111-113)
Wang H-Q, Lai H-L, Li Y, Liu Q-F, Hu S, Li L. The Relationship between Maternal Gestational Impaired Glucose Tolerance and Risk of Large-for-Gestational-Age Infant: A Meta-Analysis of 14 Studies. J Clin Res Pediatr Endocrinol. 2016; 8(3): 264-269. doi: 10.4274/jcrpe.2583
Kc K, Shakya S, Zhang H. Gestational diabetes mellitus and macrosomia: a literature review. Ann Nutr Metab. 2015; 66 (Suppl 2): 14-20. doi: 10.1159/000371628
Burumkulova FF. Gestational diabetes mellitus (endocrinological, obstetric and perinatal aspects). Abstract of dis. cand. med. sci. M., 2011. 22 p. Russian (Бурумкулова Ф.Ф. Гестационныи сахарный диабет (эндокринологические, акушерские и перинатальные аспекты). Автореф/ дис. … канд. мед наук. М., 2011. 22 с.)
Wang H-Q, Lai H-L, Li Y, Liu Q-F, Hu S, Li L. The Relationship between Maternal Gestational Impaired Glucose Tolerance and Risk of Large-for-Gestational-Age Infant: A Meta-Analysis of 14 Studies. J Clin Res Pediatr Endocrinol. 2016. 8 (3). 264-269. doi:10.4274/jcrpe.2583
Shah BR, Sharifi F. Perinatal outcomes for untreated women with gestational diabetes by IADPSG criteria: a population-based study. BJOG. 2020; 127(1): 116-122. doi: 10.1111/1471-0528.15964
Kautzky-Willer A, Harreiter J, Bancher-Todesca D, Berger A, Repa A, Lechleitner M, Weitgasser R. Gestational diabetes mellitus. Wien Klin Wochenschr. 2016; 128 (Suppl 2): S103-112. doi: 10.1007/s00508-015-0941-1
Mitanchez D. Fetal and neonatal complications of gestational diabetes: perinatal mortality, congenital malformations, macrosomia, shoulder dystocia, birth injuries, neonatal outcomes. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction. 2010; 39(8 Suppl 2): S189-199. doi: 10.1016/S0368-2315(10)70046-6
Yogev Y, Langer O. Pregnancy outcome in obese and morbidly obese gestational diabetic women. Eur J Obstet Gynecol Reprod Biol. 2008; 137: 21-26
Timmermans YEG, van de Kant KDG, Oosterman EO, Spaanderman MEA, Villamor‐Martinez E, Kleijnen J, Vreugdenhi ACE. The impact of interpregnancy weight change on perinatal outcomes in women and their children: A systematic review and meta-analysis. Obes Rev. 2019 Nov 21. doi: 10.1111/obr.12974
Stoyanov GS, Kobakova I, Stoev L, Popov H, Shishkov SR, Bratoeva K. Histological Changes in Severe Diabetic Fetopathy: An Autopsy Case Report. Cureus. 2019; 11(3): e4199. doi: 10.7759/cureus.4199
Sentilhes L, Sénat MV, Boulogne AI, Deneux-Tharaux C, Fuchs F, Legendre G et al. Shoulder dystocia: Guidelines for clinical practice. J Gynecol Obstet Biol Reprod (Paris). 2015; 44(10): 1303-1310. doi: 10.1016/j.jgyn.2015.09.053
Athukorala C, Crowther CA, Willson K. Women with gestational diabetes mellitus in the ACHOIS trial: risk factors for shoulder dystocia. J Obstet Gynaecol. 2007; 47(1): 37-41
Rotem R, Salem-Yaniv S, Sandler-Rahat H, Yohay D, Sade Sh, Yahav L, Weintraub AY. Adherence to postpartum diabetes mellitus screening, do associated pregnancy complications make a difference? Diabetes Res Clin Pract. 2019; 2: 107972. doi: 10.1016/j.diabres.2019.107972
Wei Y, Yang H. Variation of prevalence of macrosomia and cesarean section and its influencing factors. Zhonghua Fu Chan Ke Za Zhi. 2015; 50(3): 170-176
Moses VG, Moses KB. Clinical manifestations of systemic lesions of connective tissue in women of early reproductive age with varicose veins of the small pelvis. Bulletin of Siberian medicine. 2006; 1: 87-90. Russian (Мозес В.Г., Мозес К.Б. Клинические проявления системного поражения соединительной ткани у женщин раннего репродуктивного возраста с варикозным расширением вен малого таза //Бюллетень сибирской медицины. 2006. Т. 5, № 1. С. 87-90)
Moses VG. The role of systemic lesion of connective tissue in the genesis of varicose veins of the small pelvis in adolescents. Kazan medical journal. 2006; 87(2): 102-104. Russian (Мозес В.Г. Роль системного поражения соединительной ткани в генезе варикозного расширения вен малого таза у подростков //Казанский медицинский журнал. 2006. Т. 87, № 2. С. 102-104)
Valerio E, Riello L, Chirico M, Semenzato R, Cutrone M. Neonatal Hairy Ear Pinnae and Gestational Diabetes: Just a Coincidence? Pediatr Dermatol. 2015; 32(6): e300-302. doi: 10.1111/pde.12677
Opara PI, Jaja T, Onubogu UC. Morbidity and mortality amongst infants of diabetic mothers admitted into a special care baby unit in Port Harcourt, Nigeria. Ital J Pediatr. 2010; 36(1): 77. doi: 10.1186/1824-7288-36-77
Opati P, Zheng R, Wang J, Xin Y, Zhao H, Bi D. Comparison of neonatal outcomes in macrosomic infants of diabetic and non-diabetic mothers. J Neonatal Perinatal Med. 2015 Mar 10
Sacks DA. The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy. J Matern Fetal Neonatal Med. 2012; 25(1): 45-49. doi: 10.3109/14767058.2012.626929
Schimmel MS, Bromiker R, Soll RF. Neonatal polycythemia: is partial exchange transfusion justified? Clin Perinatol. 2004; 31(3): 545-553
Ibatullin AG, Tikhonova OA, Gurkina OV. Adaptation of newborn children from mothers with diabetes mellitus. Smolenskij medicinskij al'manah 2016; 4: 148-151. Russian (Ибатулин А.Г., Тихонова О.А., Гуркина О.В. Адаптация новорожденных детей от матерей с сахарным диабетом //Смоленский медицинский альманах. 2016. № 4. С. 148-151)
Thevarajah A, Simmons D. Risk factors and outcomes for neonatal hypoglycaemia and neonatal hyperbilirubinaemia in pregnancies complicated by gestational diabetes mellitus: a single centre retrospective 3-year review. Diabet Med. 2019; 36(9): 1109-1117. doi: 10.1111/dme.13962
Guillén-Sacoto MA, Barquiel B, Hillman N. Gestational diabetes mellitus: glycemic control during pregnancy and neonatal outcomes of twin and singleton pregnancies. Endocrinol Diabetes Nutr. 2018; 65(6): 319-327. doi: 10.1016/j.endinu.2018.01.011
Sarkar S, Rosenkrantz TS. Neonatal polycythemia and hyperviscosity. Semin Fetal Neonatal Med. 2008; 13(4): 248-255. doi: 10.1016/j.siny.2008.02.003
Krautzig A, Christoph J, Kattner E. Heart failure caused by myocardial hypertrophy in diabetic fetopathy. Z Geburtshilfe Neonatol. 1999; 203(5): 221-224
Widerker TV, Remneva OV, Fadeeva NI. Clinical, instrumental and biochemical markers of fetal hypoxia in predicting lesions of the central nervous system in a newborn. Russian Bulletin of the Obstetrician-Gynecologist. 2008; 8: 4-8. Russian (Видеркер Т.В., Ремнева О.В., Фадеева Н.И. Клинические, инструментальные и биохимические маркеры гипоксии плода в прогнозировании поражений центральной нервной системы у новорожденного //Российский вестник акушера-гинеколога. 2008. № 8(6). С. 4-8)
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M et al. Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy. Gynecol Endocrinol. 2016; 32(7): 548-552. doi: 10.3109/09513590.2016.1138461
Litvinenko IA. The effectiveness of predicting diabetic fetopathy in pregnant women with gestational diabetes. Abstract of Candidate of Medical Science. M., 2012. 23 p. Russian (Литвиненко И.А. Эффективность прогнозирования диабетической фетопатии у беременных с гестационным сахарным диабетом. Автореф. дис. … канд. мед.наук. М., 2012. 23 с.)