CHANGE IN FUNCTIONAL PARAMETERS OF PLATELETS IN TUBAL PREGNANCY IN VARIOUS CLINICAL SITUATIONS
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Abstract
The aim – to assess the changes in serum platelet counts, such as the average platelet count (MPV), platelet width (PDW), and discuss the mechanism of these changes in tubal pregnancy in early gestation in various clinical situations.
Materials and methods. A retrospective study of 90 clinical cases of tubal pregnancy, 25 observations with a rupture of the fallopian tube (PMT), 65 patients with progressive tubal pregnancy (PTB) was carried out. In 31 pregnant women, at terms up to 4-5 weeks, with positive β-hCG, no ultrasound signs of uterine pregnancy were observed. The study was conducted in the period from 2012-2016.
Results. MPV was lower in the group with PTB, especially with PMT, but higher in patients who did not have ultrasound signs of uterine pregnancy in the early stages, compared to those in the control group. The highest PDW values were higher at RMT.
The conclusion.The number of platelets was significantly lower in situations with PMT compared with the PGT and the control group. A more pronounced inflammation reaction occurs in clinical cases with PMT, which may contribute to lower MPV values and an increase in PDW.
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Miscarriage in early pregnancy: diagnosis and tactics of reference: Clinical recommendations (protocol of treatment), approved by the Ministry of Health of Russia and ROAG of June 7, 2016; 15-4/10/2-3482. 32 p. Russian (Выкидыш в ранние сроки беременности: диагностика и тактика ведения: Клинические рекомендации (протокол лечения), утверждены Минздравом России и РОАГ от 7 июня 2016 г. № 15-4/10/2-3482. 32 с.)
Varma R, Gupta J. Tubal ectopic pregnancy. Clin Evid. (Online) 2009; pii: I406
Wagner DD, Burger PC. Platelets in inflammation and thrombosis. Arterioscler Thromb Vasc Biol. 2003; 23: 2131-2137. doi: 10.1161/01.ATV.0000095974.95122.EC
Krivchik GV The ways of feto-infantile losses reduction under existing conditions of big industrial centre of Western Siberia. National priorities of Russia. 2009; 1: 151-155. Russian (Кривчик Г.В. Пути снижения фето-инфантильных потерь в условиях крупного промышленного центра Западной Сибири //Национальные приоритеты России. 2009. № 1. C. 151-155)
The main indicators of the obstetric-gynecological service in the Russian Federation in 2015. Handbook of the Ministry of Health of the Russian Federation. Moscow, 2016. Russian (Основные показатели деятельности акушерско-гинекологической службы в Российской Федерации в 2015 году. Справочник Министерства Здравоохранения Российской Федерации. Москва, 2016)
Shaw JLV, Dey SK, Critchley HOD, Horn AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Human Reproduction Update. 2010; 16(4): 432-444. doi: 10.1093/humupd/dmp057
Tay JI, Moore J, Walker JJ. Ectopic pregnancy. BMJ. 2000; 320: 916-919. doi.org/10.1136/bmj.320.7239.916
Cartwright J, Duncan WC, Critchley HOD, Horne AW. Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities. Reproduction. 2009; 138(1): 9-22. doi: 10.1530/REP-09-0060
Cabar FR, Fettback PB, Pereira P, Zugaib M. Serum markers in the diagnosis of tubal pregnancy. Clinics. 2008; 63: 701-708. doi: 10.1590/S1807-59322008000500021
Turgut A, Sak ME, Ozler A. Alterations of peripheral blood cells in tubal ectopic pregnancy. Ginekol Pol. 2013; 84: 193-196
Gasparyen AY, Ayvazyen L, Mikhalidis D. MPV: a link between thrombosis and inflammation? Current Pharmaceutical Design. 2011; 17(1): 47-58. doi: 10.2174/138161211795049804
Dundar O, Yoruk P, Tutuncu L. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of preeclampsia. Prenat Diag. 2008; 28: 1052-1056. doi: 10.1002/pd.2126
Beyan C, Kaptan K, Ifran A. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggegation responses in healthy volunteers. J Thromb Thrombolysis. 2006; 22(3): 161-164
Vagdatli E, Gounari E, Lazaridou E. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010; 14: 28-32