DYSLIPIDEMIA IN NEWBORNS FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS: ARE THE LIPID TRANSPORT SYSTEMS DISRUPTED?
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Abstract
The aim of the research – to evaluate blood lipid spectrum parameters and features of the lipid transport system in newborns from women with gestational diabetes mellitus (GDM).
Design – a prospective cohort comparative study was conducted.
Materials and methods. A total of 88 newborns were examined. Including full-term – 40 (45.4%), late premature – 24 (27.2%). The main group consisted of 64 (72.7%) newborns from women with gestational diabetes mellitus. The comparison group consisted of 24 (27.2%) newborns from women without impaired carbohydrate metabolism.
Results. The article presents data on the course of the neonatal period and the features of lipid metabolism in children from women with gestational diabetes mellitus. It is shown that the anthropometric indicators at birth are significantly higher in the main group. The children of the main group also have a higher body mass index (BMI) and ponderal index. The Apgar score was lower in children of the first group. Children of women with GDM had manifestations of diabetic fetopathy (DF) of varying severity. It has been shown that when analyzing the blood lipid spectrum in children from women with GDM, there is dyslipidemia in the form of higher levels of cholesterol (cholesterol), low-density lipoproteins (LDL) and a decrease in the level of high-density lipoproteins (HDL) compared with children from the comparison group. When analyzing the levels of apolipoprotein A-1 (ApoA) and apolipoprotein B (APB) transport proteins, no significant differences were obtained between the studied groups.
Conclusion. Children of women with GSD have high rates of physical development, more often suffer from respiratory disorders requiring respiratory support. Already in the newborn period, these children have dyslipidemia, which requires further study of changes in the lipid transport system at an early age.
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