POSSIBILITIES OF PREDICTING PREMATURE BIRTH
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Abstract
The conducted scientific research is devoted to the problem of finding predictors of preterm birth, because the available tests either have low information content or are an expensive technique.
The purpose of the study. To develop a computer program for predicting premature births among women in the Kemerovo region – Kuzbass.
Materials and methods. To determine the most significant independent predictors of preterm birth, we conducted a study (n = 350), which analyzed more than 100 factors related to the development of preterm birth. As a result of binary logistic regression, four independent laboratory, clinical and paraclinical predictors of the risk of preterm birth were identified.
Results. Based on the study, the most significant indicators affecting the risk of premature birth were identified. They include levels of prostaglandin class A antibodies, benzo[a]pyrene class G antibodies, cervical length at 18+0-20+6 weeks of pregnancy and smoking.
Conclusion. You can use the program by clicking on the QR-code.
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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References
Dolgushina VF, Alikhanova ES, Kurnosenko IV, Nadvikova TV. Isthmico-cervical insufficiency associated with cervicovaginal infections: features of the course of pregnancy and perinatal outcomes. Ural medical journal. 2021. T.20, №1.S. 23-29. Russian (Долгушина В.Ф., Алиханова Е.С., Курносенко И.В., Надвикова Т.В. Истмико-цервикальная недостаточность, ассоциированная с цервиковагинальными инфекциями: особенности течения беременности и перинатальные исходы //Уральский медицинский журнал. 2021. Т. 20, № 1. С. 23-29.) DOI: 10.52420/2071-5943-2021-20-1-23-29
Nikolova T, Uotila J, Nikolova N, Bolotskikh VM, Borisova VY, Di Renzo GC. Prediction of spontaneous preterm delivery in women presenting with premature labor: a comparison of placenta alpha microglobulin-1, phosphorylated insulin-like growth factor binding protein-1, and cervical length. Am J Obstet Gynecol. 2018; 219(6): 610.e1-610.e9. DOI: 10.1016/j.ajog.2018.09.016
Melchor JC, Navas H, Marcos M, Iza A, De Diego M, Rando D, et al. Predictive performance of PAMG-1 vs fFN test for risk of spontaneous preterm birth in symptomatic women attending an emergency obstetric unit: retrospective cohort study. Ultrasound Obstet Gynecol. 2018; 51(5): 644-649. DOI: 10.1002/uog.18892
Reichmann JP. Home uterine activity monitoring: the role of medical evidence. Obstet Gynecol. 2008; 112(2): 325-327. DOI: 10.1097/AOG.0b013e3181801d66
Romero R. Spontaneous preterm labor can be predicted and prevented. Ultrasound Obstet Gynecol. 2021. 57(1): 19-21. DOI: 10.1002/uog.23565
Honest H, Forbes CA, Durée NG, Norman G, Duffy SB, Tsourapas A, et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess. 2009; 13(43): 1-627. DOI: 10.3310/hta13430
Souza RT, McKenzie EJ, Jones B, de Seymour JV, Thomas MM, Zarate E, et al. Trace biomarkers associated with spontaneous preterm birth from the maternal serum metabolome of asymptomatic nulliparous women – parallel case-control studies from the SCOPE cohort. Sci Rep. 2019; 9(1): 13701. DOI: 10.1038/s41598-019-50252-7
Nooshin E, Mahdiss M, Maryam R, Amineh S-N, Somayyeh NT. Prediction of Preterm Delivery by Ultrasound Measurement of Cervical Length and Funneling Changes of the Cervix in Pregnant Women with Preterm Labor at 28-34 weeks of Gestation. J Med Life. 2020; 13(4): 536-542. DOI: 10.25122/jml-2020-0069
Kuusela P, Jacobsson B, Hagberg H, Fadl H, Lindgren P, Wesström J, et al. Second-trimester transvaginal ultrasound measurement of cervical length for prediction of preterm birth: a blinded prospective multicentre diagnostic accuracy study. BJOG. 2021; 128(2): 195-206. DOI: 10.1111/1471-0528.16519
Li Q, Reeves M, Owen J, Keith LG. Precocious cervical ripening as a screening target to predict spontaneous preterm delivery among asymptomatic singleton pregnancies: a systematic review. Am J Obstet Gynecol. 2015; 212(2): 145-156. DOI: 10.1016/j.ajog.2014.07.003
Khalifeh A, Berghella V. Universal cervical length screening in singleton gestations without a previous preterm birth: ten reasons why it should be implemented. Am J Obstet Gynecol. 2016. 214(5): 603.e1-5. DOI: 10.1016/j.ajog.2015.12.017
Kuusela P, Jacobsson B, Hagberg H, Fadl H, Lindgren P, Wesström J, et al. Second-trimester transvaginal ultrasound measurement of cervical length for prediction of preterm birth: a blinded prospective multicentre diagnostic accuracy study. BJOG. 2021; 128(2): 195-206. DOI: 10.1111/1471-0528.16519
Rozenberg P. Is universal screening for cervical length among singleton pregnancies with no history of preterm birth justified? J Gynecol Obstet Biol Reprod (Paris). 2016; 45(10): 1337-1345. DOI: 10.1016/j.jgyn.2016.09.023
Turienzo CF, Bick D, Briley AL, Bollard M, Coxon K, Cross P, et al. Midwifery continuity of care versus standard maternity care for women at increased risk of preterm birth: A hybrid implementation-effectiveness, randomised controlled pilot trial in the UK. PLoS Med. 2020; 17(10): e1003350. DOI: 10.1371/journal.pmed.1003350
Gudicha DW, Romero R, Kabiri D, Hernandez-Andrade E, Pacora P, Erez O, et al. Personalized assessment of cervical length improves prediction of spontaneous preterm birth: a standard and a percentile calculator. Am J Obstet Gynecol. 2021; 224(3): 288.e1-288.e17. DOI: 10.1016/j.ajog.2020.09.002
Home Uterine Activity Monitors - Final Class II Special Controls Guidance for Industry and FDA Reviewers. March 9, 2001
Berghella V, Saccone G. Fetal fibronectin testing for prevention of preterm birth in singleton pregnancies with threatened preterm labor: A systematic review and metaanalysis of randomized controlled trials. Am J Obstet Gynecol. 2016; 215(4): 431-438. DOI: 10.1016/j.ajog.2016.04.038
Nikolova T, Bayev O, Nikolova N, Di Renzo GC. Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor. J Perinat Med. 2015; 43(4): 395-402. DOI: 10.1515/jpm-2014-0300
Hallingström M, Zedníková P, Tambor V, Barman M, Vajrychová M, Lenčo J, et al. Mid-trimester amniotic fluid proteome's association with spontaneous preterm delivery and gestational duration. PLoS One. 2020. 15(5): e0232553. DOI: 10.1371/journal.pone.0232553
Rahkonen L, Unkila-Kallio L, Rutanen EM, Paavonen J. Factors affecting decidual IGFBP-1 levels in the vagina and cervix in the first and mid-second trimester of pregnancy. BJOG. 2009; 116(1): 45-54. DOI: 10.1111/j.1471-0528.2008.01959.x
Gokce A, Kalafat E, Sukur YE, Altinboga O, Soylemez F. Role of cervical length and placental alpha microglobulin-1 to predict preterm birth. J Matern Fetal Neonatal Med. 2022; 35(17): 3388-3392. DOI: 10.1080/14767058.2020.1818222
Kashanian M, Eshraghi N, Rahimi M, Sheikhansari N. Evaluation of placental alpha microglobulin-1(PAMG1) accuracy for prediction of preterm delivery in women with the symptoms of spontaneous preterm labor; a comparison with cervical length and number of contractions. J Matern Fetal Neonatal Med. 2022; 35(3): 534-540. DOI: 10.1080/14767058.2020.1728246