COMPREHENSIVE ASSESSMENT OF BIOCHEMICAL MARKERS IN THE BLOOD IN PREGNANT WOMEN SUFFERING FROM HYPERTENSIVE DISORDERS
Main Article Content
Abstract
Aim – complex assessment of the content of biochemical markers endothelin–1 and sVCAM-1 in the 1-st trimester in pregnant women suffering from chronic arterial hypertension, depending on the development of large obstetric syndromes.
Materials and methods. 84 pregnant woman aged 18-45 years were examined at 10-13 weeks of pregnancy. The main group consisted of 54 women suffering from arterial hypertension (stage I), the control group consisted of 30 healthy women. The levels of biochemical markers were determined in blood serum samples by solid-phase enzyme immunoassay.
Results. According to the results of the study, it was revealed that women with hypertension in the 1-st trimester had statistically significantly higher levels of endothelin-1 and sVCAM-1 compared to healthy woman. Besides, in chronic arterial hypertension, pregnancy is significantly more often complicated by preeclampsia, fetal development delay and placental insufficiency compared with pregnant women without hypertensive disorders. It has been established that chronic arterial hypertension occurs against the background of an inflammatory process and a violation of the functional state of the vascular endothelium in the 1-st trimester in pregnant woman.
Conclusion. Vascular adhesion molecule can act as a marker of chronic AH in pregnant women in the early stages of gestation. To assess the prognostic role of endothelin-1 in the development of large obstetric syndromes, further study of the significance of this peptide in a larger sample of patients, as well as in combination with other biochemical and biophysical markers, is required.
Downloads
Article Details
Issue
Section
References
Pustotina OA. Arterial hypertension in pregnant women: diagnosis, treatment, prevention of complications. Farmateka. 2017; 3: 12-21. Russian (Пустотина О.А. Артериальная гипертензия у беременных: диагностика, лечение, профилактика осложнений //Фарматека. 2017. № 3. С. 12-21)
Shikh EV, Zhukova OV, Ostroumova OD, Sharonova SS. To the question of pharmacogenetic approaches in the treatment of arterial hypertension in pregnant women. Obstetrics and Gynecology. 2020; 2: 22-28. Russian (Ших Е.В., Жукова О.В., Остроумова О.Д., Шаронова С.С. К вопросу о фармакогенетических подходах в лечении артериальной гипертензии у беременных //Акушерство и гинекология. 2020. № 2. С. 22-28.) DOI: 10.18565/aig.2020.2.22-28
Omboni S, Posokhov IN, Parati G, Avolio A, Rogoza AN, Kotovskaya YV, et al. Vascular Health Assessment of The Hypertensive Patients (VASOTENS) Registry: Study Protocol of an International, Web-Based Telemonitoring Registry for Ambulatory Blood Pressure and Arterial Stiffness. JMIR Res Protoc. 2016; 5(2): e137. DOI: 10.2196/resprot.5619
Rokоtyanskаya EA, Panova IA, Malyshkina AI, Fetisova IN, Fetisov NS, Kharlamova NV, Kuligina MV. Technologies for Prediction of Preeclampsia. Modern Technologies in Medicine. 2020; 12(5): 78. Russian (Рокотянская Е.А., Панова И.А., Малышкина А.И., Фетисова И.Н., Фетисов Н.С., Харламова Н.В., Кулигина М.В. Технологии прогнозирования преэклампсии //Современные технологии в медицине. 2020. Т. 12, № 5. С. 78-86.) doi.org/10.17691/stm2020.12.5.09
Sidorova IS, Nikitina NA, Filippov OS, Guseva EV, Ageev MB, Kokin AA. Resolved and unresolved issues of preeclampsia based on the results of the analysis of maternal mortality over the past 10 years. Obstetrics and Gynecology. 2021; 4: 64-74. Russian (Сидорова И.С., Никитина Н.А, Филиппов О.С., Гусева Е.В., Агеев М.Б., Кокин А.А. Решенные и нерешенные вопросы преэклампсии по результатам анализа материнской смертности за последние 10 лет //Акушерство и гинекология. 2021. № 4. С. 64-74.) DOI: 10.18565/aig.2021.4.64-74
Hollegaard B, Lykke JA, Boomsma J. Time from pre-eclampsia diagnosis to delivery affects future health prospects of children. Evol Med Public Health. 2017; 2017, Is 1: 53-66. DOI 10.1093/emph/eox004
Dolgushina VF, Syundyukova EG, Chulkov VS, Ryabikina MG. Long-term consequences of hypertensive disorders during pregnancy. Obstetrics and Gynecology. 2021; 10: 14-20. Russian (Долгушина В.Ф., Сюндюкова Е.Г., Чулков В.С., Рябикина М.Г. Отдаленные последствия перенесенных гипертензивных расстройств во время беременности //Акушерство и гинекология. 2021. № 10. С. 14-20). DOI: 10.18565/aig.2021.10.14-20
Hutcheon JA, Stephansson O, Cnattingius S, Bodnar LM, Wikström AK, Johansson K. Pregnancy Weight Gain Before Diagnosis and Risk of Preeclampsia: A Population-Based Cohort Study in Nulliparous Women. Hypertension. 2018; 72(2): 433-441. DOI: 10.1161/HYPERTENSIONAHA.118.10999
Smirnova E.V., Panova I.A., Nazarov S.B., Rokotyanskaya E.A. Features of endothelial dysfunction in women with various forms of hypertensive disorders during pregnancy and after childbirth. Russian Bulletin of the Obstetrician-Gynecologist. 2020; 20(6): 21-26. Russian (Смирнова Е.В., Панова И.А., Назаров С.Б., Рокотянская Е.А. Особенности эндотелиальной дисфункции у женщин с различными формами гипертензивных расстройств во время беременности и после родов //Российский вестник акушера-гинеколога. 2020. Т. 20, № 6. С. 21-26.) DOI: 10.17116/rosakush20202006121
Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2020; 15(5): 275-289. DOI: 10.1038/s41581-019-0119-6
Podzolkov VI, Bragina AE, Natkina DU, Safronova TA, Nebieridze NN, Podshibyakina EV. The state of the vascular wall and microcirculation parameters in controlled and uncontrolled arterial hypertension. Rational pharmacotherapy in cardiology. 2019; 15(4): 495-501. Russian (Подзолков В.И., Брагина А.Е., Наткина Д.У., Сафронова Т.А., Небиеридзе Н.Н., Подшибякина Е.В. Состояние сосудистой стенки и параметры микроциркуляции при контролируемой и неконтролируемой артериальной гипертензии //Рациональная фармакотерапия в кардиологии. 2019. Т. 15, № 4. С. 495-501.) DOI: 10.20996/1819-6446-2019-15-4-495-501
Chistyakova GN, Remizova II, Bychkova SV, Dan'kova IV. Features of the functional activity of the endothelium in pregnant women with hypertensive disorders and their newborns. Problems of reproduction. 2020; 26(1): 95-103. Russian (Чистякова Г.Н., Ремизова И.И., Бычкова С.В., Данькова И.В. Особенности функциональной активности эндотелия у беременных женщин c гипертензивными расстройствами и их новорожденных детей //Проблемы репродукции. 2020. Т. 26, № 1. С. 95-103.) DOI: 10.17116/repro20202601195
Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Polloc J, et al. Endothelin. Pharm Reviews. 2016; 68(2): 357-418. DOI: 10.1124/pr.115.011833
Podzolkov VT, Safronova T, Nebieridze N, Loriya IA, Cherepanov A. Transforming growth factor and arterial stiffness in patients with uncontrolled arterial hypertension. Georgian Medical News. 2021; 310: 77-83
Tesauro M, Mauriello A, Rovella V, Annicchiarico-Petruzzelli M, Cardillo C, Melino G, Di Daniele N. Arterial ageing: from endothelial dysfunction to vascular calcification. J Intern Med. 2017; 281(5): 471-482. DOI: 10.1111/joim.12605
Panova IA, Rokotianskaya EA, Kuzmenko GN, Kudryashova AV, Popova IG, Sytova LA, et al. The markers of inflammation reaction and dysfunction of endothelium in pregnant women with hypertension disorders of various genesis. Russian Clinical Laboratory Diagnostics. 2016; 61(10): 692-696. Russian (Панова И.А., Рокотянская Е.А., Кузьменко Г.Н., Кудряшова А.В., Попова И.Г., Сытова Л.А., и др. Характер воспалительной реакции и дисфункции эндотелия у беременных с гипертензивными расстройствами различного генеза //Клиническая лабораторная диагностика. 2016. Т. 61, № 10. C. 692-696.) DOI: 10.18821/0869-2084-2016-61-10-692-696
Averkieva VS, Lisyanskaya MV. The innovative biomarkers for the diagnosis and prediction of preeclampsia. Poliklinika. 2016; 1-3: 20-23. Russian (Аверкиева В.С., Лисянская М.В. Инновационные биомаркеры для диагностики и прогноза преэклампсии //Поликлиника. 2016. № 1(3). C. 20-23)
Liu B, Liu L, Cui S, Qi Y, Wang T. Expression and Significance of MicroRNA-126 and VCAM-1 in Placental Tissues of Women with Early-Onset Preeclampsia. J Obstet Gynaecol Res. 2021; 47: 2042-2050
Guerby P, Tasta O, Swiader A, Pont F, Bujold E, Parant O, et al. Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia. Redox Biol. 2021; 40: 101861. DOI: 10.1016/j.redox.2021.101861