MALIGNANT ARTERIAL HYPERTENSION IN A CHILD WITH ATYPICAL HEMOLYTIC-UREMIC SYNDROME
Main Article Content
Abstract
Atypical hemolytic-uremic syndrome (aHUS) is a rare orphan disease. In the Altai Region, two cases of aHUS among children have been recorded. The disease is characterized by a severe course with high mortality, frequent development of complications and a possible outcome in the terminal stage of chronic renal failure. The severe course of aНUS may be aggravated by the development of extrarenal complications. In addition, patients with atypical hemolytic-uremic syndrome have a high risk of developing relapses of the disease - acute manifestations of aНUS. The presented clinical observation describes the unfavorable course of aHUS complicated by secondary malignant arterial hypertension.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Zеnchenko OA, Vykhodtseva GI, Skudarnov EV, Volkova YuV, Dorokhov NA, Malyuga OM, Cherkasova TM. Chronic renal failure in children of the Altai Territory. Questions of practical pediatrics. 2019; 14(5): 16-20. Russian (Зенченко О.А., Выходцева Г.И., Скударнов Е.В., Волкова Ю.В., Дорохов Н.А., Малюга О.М., Черкасова Т.М. Хроническая почечная недостаточность у детей Алтайского края //Вопросы практической педиатрии. 2019. Т. 14, № 5. С. 16-20.) doi: 10.20953/1817-7646-2019-5-16-20
Schaefer F, Ardissino G, Ariceta G, Fakhouri F, Scully M, Isbel N, et al. Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome. Kidney Int. 2018; 94(2): 408-418. doi: 10.1016/j.kint.2018.02.029
Tsygin AN, Vashurina TV, Margieva TV, et al. Federal clinical guidelines for the care of children with hemolytic-uremic syndrom. Pediatric pharmacology. 2015; 12(4): 447-455. Russian (Цыгин А.Н., Вашурина Т.В., Маргиева Т.В., и др. Федеральные клинические рекомендации по оказанию помощи детям с гемолитико-уремическим синдромом //Педиатрическая фармакология. 2015. Т. 12, № 4. С. 447-455.) doi: 10.15690/pf.v12i4.1427
Kozlovskaya NL, Prokopenko EI, Emirova HM, Serikova SYu. Clinical recommendations for the diagnosis and treatment of atypical hemolytic-uremic syndrome. Nephrology and dialysis. 2015; 17(3): 242-264.Russian (Козловская Н.Л., Прокопенко Е.И., Эмирова Х.М., Серикова С.Ю. Клинические рекомендации по диагностике и лечению атипичного гемолитико-уремического синдрома //Нефрология и диализ. 2015. Т. 17, № 3. С. 242-264)
Laurence J, Haller H, Mannucci PM, Nangaku M, Praga M, Rodriguez de Cordoba S. Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis. Clin. Adv. Hematol. Oncol. 2016; 14(Suppl. 11): 2-15
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, et al. An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr. Nephrol. 2016; 31(1): 15-39. doi: 10.1007/s00467-015-3076-8
Bаyko SV, Sukalo AV, Sudnovskaya KA. Hemolytic-uremic syndrome in children: epidemiology, features of clinical and laboratory course, treatment and outcomes (single-center study). Nephrology and dialysis. 2016; 18(3): 282-299. Russian (Байко С.В., Сукало А.В., Судновская К.А. Гемолитико-уремический синдром у детей: эпидемиология, особенности клинико-лабораторного течения, лечение и исходы (одноцентровое исследование) //Нефрология и диализ. 2016. Т. 18, № 3. С. 282-299)
Emirova Kh, Volokhina E, Tolstova E, Bert van den Heuvel. Recovery of renal function after long-term dialysis and resolution of cardiomyopathy in a patient with aHUS receiving eculizumab. BMJ Case Rep. 2016; 2016: pii: bcr2015213928. doi: 10.1136/bcr-2015-213928