FEATURES OF STRUCTURAL AND METABOLIC PARAMETERS OF UMBILICAL CORD BLOOD IMMUNE SYSTEM CELLS IN PREMATURE NEWBORNS WITH RESPIRATORY DISORDERS SYNDROME
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Abstract
Respiratory disorders syndrome is the main of the most severe forms of pathology of premature newborns, among the causes of neonatal mortality, this pathology occupies a leading place. Early prediction and diagnosis of respiratory disorders, the creation of an effective correction is an urgent issue for the preservation of the health of the future generation.
The purpose of the study – to determine the significance of changes in the structural and metabolic parameters of the cells of the umbilical cord blood immune system in the syndrome of respiratory disorders in premature newborns to identify their pathogenetic significance.
Materials and methods. 64 premature newborns were examined, group 1 (49 newborns) included children without SDR, and group 2 (15 children) included newborns with SDR. We studied the enzymes of the immune system cells in the umbilical cord blood of premature newborns: succinate dehydrogenase and acid phosphatase, as well as the spectrum of neutral lipids and phospholipids.
Results. The statistically significant increase in the activity of the marker enzyme lysosomal acid phosphatase and a decrease in the content of phosphatidylcholine, the main structural component of cell membranes and surfactant, which is a substrate for lysosomal enzymes, revealed in the blood lymphocytes of the studied premature newborns, indicates the involvement of lysosomes in the pathogenetic processes of the development of neonatal respiratory disorders syndrome.
Conclusion. The data obtained by us can help to expand the understanding of the spectrum of indications for the appointment of drugs that have the ability to stabilize the membranes of lysosomes and thereby reduce their functional activity.
Keywords
Author Biographies
Наталья Владимировна Лисихина,
candidate of medical sciences, assistant, department of outpatient pediatrics and propedeutics of childhood diseases with the course of PO; docent, department of criminalisticsМарина Юрьевна Галактионова,
Galaktionova Marina Yurievna
MD, PhD, professor, head of department of polyclinic pediatrics and propaedeutics of children’s diseases.
She has been working as the Principal Scientific Researcher at the Clinical Department of Somatic and Mental Wellbeing in Paediatrics since 1998. She was working as an Academic Secretary at the State Medical Research Institute for Northern Problems, Siberian Division of Russian Academy of Medical Sciences (February, 2001 – June, 2005).
Her priorities are: the studying of the development of the heart rhythm disorder and the cardiac conduction disease in children with the effect of of perinatal pathology of the CNS and syndrome of connective tissue dysplasia; the assessment of heart rate variability, central and cerebral hemodynamics indicators, vegetal homeostasis in children for the detection of the adaptational capacity of the cardiovascular system; the development of diagnostic protocols for identification and technologies of rehabilitation in children and adolescents taking into account the individual-typological approach with the aim of assessment for the health status.
She is an author of 327 scientific works, including 34 studying manuals, 4 monographs, 2 invention patents.
Under her supervision there were written one Candidate thesis, she also assisted in writing several sections of two dissertations on the study of clinical and functional characteristics of cardiac rhythm and conduction in children with different somatotype and small congenital malformations of the heart.
She is a Professor of the Russian Academy of Science since 2001, a member of the Russian Society of Cardiology and the Union of Pediatricians of Russia (the author of the Hymn of the organization). She is also a member of the “Pediatrics. Pediatric surgery. Genetics” Problem Commission of Krasnoyarsk State Medical University.
The pediatrician of the highest qualification category.Юлия Анатольевна Смирнова,
anesthesiologist-resuscitator, neonatologist, head of the departmentArticle Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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