ACUTE LIVER FAILURE IN PREGNANT WOMEN DUE TO HEPATITIS E – CURRENT UNDERSTANDING OF PATHOGENESIS, TREATMENT AND PREVENTION
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Abstract
The aim of the research – to carry out an analytical review of modern sources of scientific literature covering the pathogenesis of acute liver failure induced by hepatitis E virus, treatment and prevention of complications in pregnant women with hepatitis E.
Materials and methods. The analysis of 61 domestic and foreign sources of literature on this topic.
Results. According to the scientific analysis, new data on the prevalence of hepatitis E in pregnancy in the world have been obtained. The review describes possible complications of pregnancy and childbirth associated with hepatitis E, highlighted the effectiveness of screening this disease and the tactics of managing pregnancy in infected women.
Conclusion. The hepatitis E during pregnancy is often complicated by acute liver failure, which makes it an urgent problem. The analysis shows that modern antiviral therapy with direct antiviral drugs is a promising method of treatment, and the vaccine is a method of preventing hepatitis E, however, drugs that allow treating and preventing the disease during pregnancy are under development and clinical studies.
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References
WHO. Hepatitis E vaccine: WHO position paper. Weekly Epidemiol Rec. 2015; 18: 185-200
Wong D, Purcell R, Mandyam Ammanjee S, Rama Prasad S, Pavri K. Epidemic and endemic hepatitis in India. Evidence for non A, non B hepatitis virus aetiology. Lancet. 1980; 316: 876-879
Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, Reyes GR. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology. 1991; 185: 120-131
Smith DB, Simmonds P, Jameel S, Emerson SU, Harrison TJ, Meng XJ, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol. 2014; 95: 2223-2232
Holla RP, Ahmad I, Ahmad Z, Jameel S. Molecular virology of hepatitis E virus. Semin Liver Dis. 2013; 33: 3-14
Sayed IM, Vercauteren K, Abdelwahab SF, Meuleman P. The emergence of HEV in Europe. Fut Virol. 2015; 10: 763-778
«Enteral hepatitis (hepatitis A and hepatitis E) in adults». Clinical recommendations. Moscow 2014: 1-99. Russian («Энтеральные гепатиты (гепатит А и гепатит Е) у взрослых». Клинические рекомендации. 2014: 1-99)
Krain LJ, Atwell JE, Nelson KE, Labrique AB. Fetal and neonatal health consequences of vertically transmitted hepatitis E virus infection. Am J Trop Med Hyg. 2014; 90(2): 365-370
Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, et al. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet. 2014; 384: 1766-1773
Kwo PY, Schlauder GG, Carpenter HA. Acute hepatitis E by a new isolate acquired in the United States. Mayo Clin Proc. 1997; 72: 1133-1136
Dalton HR, Stableforth W, Thurairajah P. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2008; 20: 784-790
Matsuda H, Okada K, Takahashi K, Mishiro S. Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar. J Infect Dis. 2003; 188: 944
Meng XJ. Zoonotic and foodborne transmission of hepatitis E virus. Semin Liver Dis. 2013; 33: 41-49
Haim-Boukobza S, Ferey MP, Vetillard AL, Jeblaoui A, Pelissier E, Pelletier G. Transfusion-transmitted hepatitis E in a misleading context of autoimmunity and drug-induced toxicity. J Hepatol. 2012; 57: 1374-1378
Van Eijk JJJ, Dalton HR, Ripellino P, Madden RG, Jones C, Fritz M, et al. Clinical phenotype and outcome of hepatitis e virus-associated neuralgic amyotrophy. Neurology. 2017; 89: 909-917
Haffar S, Bazerbachi F, Lake JR. HEV-associated cryoglobulinaemia and extrahepatic manifestations of hepatitis E. Lancet Infect Dis. 2015; 15: 268
Aggarwal R. Clinical presentation of hepatitis E. Virus Res. 2011; 161: 15-22
Dalton HR, Kamar N, van Eijk JJ, Mclean BN, Cintas P, Bendall RP, Jacobs BC. Hepatitis E virus and neurological injury. Nat Rev Neurol. 2016; 12: 77-85
Renou C, Lafeuillade A, Cadranel JF, Pavio N, Pariente A, Allègre T, et al. Hepatitis E virus in HIV-infected patients. AIDS. 2010; 24: 1493-1499
Grewal P, Kamili S, Motamed D. Chronic hepatitis E in an immunocompetent patient: a case report. Hepatology. 2014; 59: 347-348
Hoofnagle JH, Nelson KE, Purcell RH. Hepatitis E. N. Engl. J. Med. 2012; 367: 1237-1244
Shalimar and Acharya SK. Hepatitis e and acute liver failure in pregnancy. J Clin Exp Hepatol. 2013; 3(3): 213-224
Beniwal M, Kumar A, Kar P, Jilani N, Sharma JB. Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: A prospective study from North India. Indian J Med Microbiol. 2003; 21: 184-185
Jin H, Zhao Y, Zhang X, Wang B, Liu P. Case-fatality risk of pregnant women with acute viral hepatitis type E: a systematic review and meta-analysis. Epidemiol Infect. 2016; 144: 2098-2106
Jaiswal SP, Jain AK, Naik G, Soni N, Chitnis DS. Viral hepatitis during pregnancy. Int J Gynaecol Obstet. 2001; 72: 103-108
Khuroo MS, Teli MR, Skidmore S, Sofi MA, Khuroo MI. Incidence and severity of viral hepatitis in pregnancy. Am J Med. 1981; 70: 252-255
Kumar A, Begum N. Hepatitis E in pregnancy: an insight into etiopathogenesis. JIMSA. 2010; 23: 281-283
Fiore S, Savasi V. Treatment of viral hepatitis in pregnancy. Expert Opin Pharmacother. 2009; 10(17): 2801-2809
Kosih SL, Mozes VG. Experience of using a combined local antibiotic for nonspecific bacterial vulvoaginitis in girls. Russian Bulletin of the obstetrician-gynecologist. 2013; 1: 42-45. Russian (Косых С.Л., Мозес В.Г. Опыт использования комбинированного антибиотика местного действия при неспецифическом бактериальном вульвоагините у девочек. Российский вестник акушера-гинеколога. 2013. Т. 13, № 1. С. 42-45)
Kosykh SL, Moses VG. Diagnosis and treatment of vulvovaginitis in girls. Mother and Baby in Kuzbass. 2012; 4(51): 3-6. Russian (Косых С.Л., Мозес ВГ. Диагностика и лечение вульвовагинитов у девочек //Мать и Дитя в Кузбассе. 2012. № 4(51). С. 3-6)
Weinberg ED. Pregnancy-associated depression of cell-mediated immunity. Rev Infect Dis. 1984; 6: 814-831
Kamar N, Dalton HR, Abravanel F, Izopet J. Hepatitis E virus infection. Clin Microbiol Rev. 2014; 27: 116-138
Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994; 10: 405-455
Jilani N, Das BC, Husain SA. Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J Gastroenterol Hepatol. 2007; 22: 676-682
Prabhu SB, Gupta P, Durgapal H. Study of cellular immune response against Hepatitis E virus (HEV). J Viral Hepat. 2011; 18: 587-594
Reza Taherkhani, Fatemeh Farshadpour. Epidemiology of Hepatitis E in Pregnant Women and Children in Iran: A General Overview. J Clin Transl Hepatol. 2016; 4(3): 269-276
Mozes V. Hormonal contraception in women at risk for the development of arterial and venous thrombosis. Questions of gynecology, obstetrics and perinatology. 2009; 2: 83-87. Russian (Мозес В.Г. Гормональная контрацепция у женщин группы риска по развитию артериальных и венозных тромбозов //Вопросы гинекологии, акушерства и перинатологии. 2009. Т. 8, № 2. С. 83-87)
Salam GD, Kumar A, Kar P, Aggarwal S, Husain A, Sharma S. Serum tumor necrosis factor-alpha level in hepatitis E virus-related acute viral hepatitis and fulminant hepatic failure in pregnant women. Hepatology Research. 2013; 43(8): 826-835
Kumar A, Devi SG, Kar P, Agarwal S, Husain SA, Gupta RK, Sharma S. Association of cytokines in hepatitis E with pregnancy outcome. Cytokine. 2014; 65(1): 95-104
Bose PD, Das BC, Kumar A. et al. High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. J Hepatol. 2011; 54: 1107-1113
Banait VS, Sandur V, Parikh F, Murugesh M, Ranka P, Ramesh VS, et al. Outcome of acute liver failure due to acute hepatitis E in pregnant women. Indian J Gastroenterol. 2007; 26: 6-10
Borkakoti J, Hazam RK, Mohammad A, Kumar A, Kar P. Does high viral load of hepatitis E virus influence the severity and prognosis of acute liver failure during pregnancy? J Med Virol. 2013; 85: 620-626
Kumar N, Das V, Agarwal F, Pandey A, Agrawal S. Fetomaternal outcomes in pregnant women with hepatitis E infection; still an important fetomaternal killer with an unresolved mystery of increased virulence in pregnancy Obstet Gynecol. 2017; 14(2): 106-113
Prasad GS, Prasad S, Bhupali A, Patil AN, Parashar K. A study of hepatitis E in pregnancy: Maternal and fetal outcome. J Obstet Gynaecol India. 2016; 66: 18-23
Khuroo MS, Kamili S, Khuroo MS. Clinical course and duration of viremia in vertically transmitted hepatitis E virus (HEV) infection in babies born to HEV-infected mothers. J Viral Hepat. 2009; 16(7): 519-523
Bose PD, Das BC, Hazam RK, Kumar A, Medhi S, Kar P. Evidence of extrahepatic replication of hepatitis E virus in human placenta. J Gen Virol. 2014; 95: 1266-1271
Woolson KL, Forbes A, Vine L, Beynon L, McElhinney L, Panayi V, et al. Extra-hepatic manifestations of autochthonous hepatitis E infection. Aliment Pharmacol Ther. 2014; 40: 1282-1291
Shinde NR, Patil TB, Deshpande AS, Gulhane RV, Patil MB, Bansod YV. Clinical Profile, Maternal and Fetal Outcomes of Acute Hepatitis E in Pregnancy. Ann Med Health Sci Res. 2014; 4(Suppl 2): 133-139
EASL Clinical Practice Guidelines on hepatitis E virus infection. Journal of Hepatology. 2018; 68: 1256-1271
Zhao C, Wang Y. Laboratory diagnosis of HEV infection. Advances in Experimental Medicine and Biology. 2016; 948: 191-209
Kar P, Sengupta A. A guide to the management of hepatitis e infection during pregnancy. Expert Rev. Gastroenterol. Hepatol. 2019; 13: 205-211
Manka P, Bechmann LP, Coombes JD et al. Hepatitis E virus infection as a possible cause of acute liver failure in Europe. Clin Gastroenterol Hepatol. 2015; 13: 1836-1842
Melgaço JG, Gardinali NR, de Mello VDM et al. Hepatitis E: Update on Prevention and Control. Biomed Res Int. 2018; 2018: 5769201
Lhomme S, DebRoy S, Kamar N, Abravanel F, Metsu D, Marion O, et al. Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin. Viruses. 2019; 11(7): 630
Pischke S, Hardtke S, Bode U, Birkner S, Chatzikyrkou C, Kauffmann W, et al. Ribavirin treatment of acute and chronic hepatitis e: A single-centre experience. Liver Int. 2013; 33: 722-726
Goyal R, Kumar A, Panda SK, Paul SB, Acharya SK. Ribavirin therapy for hepatitis e virus-induced acute on chronic liver failure: A preliminary report. Antivir. Ther. 2012; 17: 1091-1096
Sinclair SM, Jones JK, Miller RK, Greene MF, Kwo PY, Maddrey WC. The Ribavirin Pregnancy Registry: An Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment. Drug Saf. 2017; 40(12): 1205-1218
Chaudhry SA, Verma N, Koren G. Hepatitis E infection during pregnancy. Can Fam Physician. 2015; 61(7): 607-608
Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a largescale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet. 2010; 376: 895-902
Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J, Xia NS. Safety of the hepatitis e vaccine for pregnant women: A preliminary analysis. Hepatology. 2012; 55: 2038