PHENOTYPIC PECULIARITIES OF ANTIMULLERS HORMONE LEVEL AND ULTRASOUND PARAMETERS OF OVARRIES IN WOMEN OF REPRODUCTIVE AGE WITH POLYSTYSTIC OVARY SYNDROME
Main Article Content
Abstract
Statistically significant differences among the main (A), anovulatory (B) and ovulatory (C) phenotypes were established in the AMH levels depending on the phenotype; ovulatory (C) and non-androgenic (D) (p < 0.05). There were no differences among the main (A) and non-androgenic (D), anovulatory (B) and ovulatory (C) phenotypes (p > 0.05).
Ultrasound parameters of the ovaries in women with PCOS of the main (A), ovulatory (C) and non-androgenic (D) phenotypes were significantly larger compared to healthy women (p < 0.05). In anovulatory (B) phenotype, these indicators did not differ compared to the control group (p = 0.128).
According to the ultrasound parameters of the ovaries, the main (A), ovulatory (C) and non-androgenic (D) phenotypes did not differ (p > 0.05). In the anovulatory (B) phenotype, the ultrasound parameters were lower than in the main (A), ovulatory (C) and non-androgenic (D) phenotypes (p < 0.05).
Conclusion. The study of indicators of ovarian reserve in women of early reproductive age with PCOS is a promising direction that will allow to more accurately determine the reproductive potential of each particular woman and influence the choice of treatment tactics. The results obtained demonstrate the need to include the definition of ovarian reserve, primarily the level of AMH, in women of early reproductive age with PCOS as an additional diagnostic criterion for diagnosis and determination of further management tactics.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Suturina LV. Polycystic ovarian syndrome in the 21st century. Obstetrics and Gynecology: News, Opinions, Training. 2017; 3(17): 86-92. Russian (Сутурина ЛВ. Синдром поликистозных яичников в 21 веке //Акушерство и гинекология: Новости. Мнения. Обучение. 2017. № 3(17). С. 86-92)
Prilepskaya VN, Ovsyannikova TV. Gynecological endocrinology. M.: MEDpress-inform, 2015. 512 p. Russian (Прилепская В.Н., Овсянникова Т.В. Гинекологическая эндокринология. М.: МЕДпресс-информ, 2015. 512 с.)
Yildiz BO. Polycystic ovary syndrome: is obesity a symptom? Women’s Health. 2013; (9): 505-507
Hassa H, Tanir HM. Comparison of clinical and laboratory characteristics of cases with polycystic ovarian syndrome based on Rotterdam's criteria and women whose only clinical signs are oligo/anovulation or hirsutism. Yildiz ZArch Gynecol Obstet. 2006; 274(4): 227-232
Nazarenko EA. Stimulation of ovarian function. M.: MEDPRESS-INFORM, 2015; 288 p. Russian (Назаренко ЕА. Стимуляция функции яичников. М.: МЕДпресс-информ, 2015. 288 с.)
Polycystic ovary syndrome in reproductive age (current approaches to diagnosis and treatment): Clinical recommendations (treatment protocol). M., 2015. 22 p. Russian (Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): Клинические рекомендации (протокол лечения). М., 2015. 22 с.)
Conway G, Dewailly D, Diamanti-Kandarakis E. The polycystic ovary syndrome. A position statement from the European Society of Endocrinology. Reproductive Endocrinology. 2015; 25: 32-52. DOI: https://doi.org/10.18370/2309-4117.2015.25.32-52. Russian (Конуэй Д, Девайли Д, Диаманти-Кандаракис Э. Синдром поликистозных яичников. Заявление о позиции Европейского общества эндокринологии //Репродуктивная эндокринология. 2015. № 25. С. 32-52. DOI: https://doi.org/10.18370/2309-4117.2015.25.32-52)
Dubrovina SO. Polycystic ovarian syndrome: a modern overview. Gynecology. 2016; 18(5): 14-17. Russian (Дубровина СО. Синдром поликистозных яичников: современный обзор //Гинекология. 2016. Т. 18, № 5. С. 14-17)
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence and phenotypes of polycystic ovary syndrome. Endocr Rev. 2016; 106(1): 6-15
Joham AE, Palomba S, Hart R. Polycystic Ovary Syndrome, Obesity, and Pregnancy. Endocr Rev. 2016; 34(2): 93-101
Ovarian reserve and fertility: the challenges of the 21st century. Rational approach to preserving the reproductive reserve as a pledge of fertility and conscious procreation. Information letter /ed. Radzinsky VE. M.: Editorial Board of the journal StatusPraesens, 2015; 24. Russia (Овариальный резерв и фертильность: сложности XXI века. Рациональный подход к сохранению репродуктивного резерва как залог фертильности и осознанного деторождения. Информационное письмо /под ред. В.Е. Радзинского. М.: Редакция журнала StatusPraesens, 2015. 24 с.)
Vembu R, Reddy NS. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Endocr Rev. 2017; 18(1): 17-21
Van Houten EL, Themmen AP, Visser JA. AntiMullerian hormone (AMH) regulator and marker for ovarian function. Ann. Endocrinol. 2010; 71(3)
Zakharov IS, Bukreeva EL. Oxidative stress in the syndrome of polycystic ovaries: prognostic value, correction possibilities. Gynecology. 2018; 20(1): 35-38. Russian (Захаров И.С., Букреева Е.Л. Оксидативный стресс при синдроме поликистозных яичников: прогностическое значение, возможности коррекции //Гинекология. 2018. Т. 20, № 1. С. 35-38)
Dubrovina SO. Polycystic ovarian syndrome: a modern overview. Gynecology. 2016; 18(5): 14-17. Russian (Дубровина СО. Синдром поликистозных яичников: современный обзор //Гинекология. 2016. Т. 18, № 5. С. 14-17)