ANTIBODIES TO BENZO(A)PYRENE AND STEROID HORMONES IN WOMEN WITH NON-DEVELOPING PREGNANCY

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ORIGINAL ARTICLES
Published:
2020-05-20
DOI:
https://doi.org/10.24411/2686-7338-2020-10021

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Гюлай Агамуса кызы Сафарова
Altai State Medical University, Barnaul
Марина Борисовна Игитова
Altai State Medical University, Barnaul
Юрий Владимирович Кореновский
Altai State Medical University, Barnaul
Елена Геннадьевна Поленок
Institute of Human Ecology of the Siberian Branch of the RAS, Kemerovo

Abstract

The levels of immunoglobulins of class A (IgA) and G (IgG) to estradiol (Es), progesterone (P) and benzo[a]pyrene (Bp) were determined in women who had undergone one or more episodes of non-developed pregnancy, including 50 patients with sporadic cases and 20 patients with normal reproductive losses compared to 30 patients in the control group. Significant differences were found in the level of antibodies to estradiol (IgA 5.27 ± 2.87 vs. 3.26 ± 1.69, p = 0.001; IgG 10.52 ± 6.97 vs. 7.08 ± 4.06, p = 0.019), progesterone (IgA 3.13 ± 1.49 vs. 2.29 ± 1.17, p = 0.012; IgG 8.05 ± 5.61 vs. 5.48 ± 3.65, p = 0.033) and benzo[s]pyrene (IgA 4.55 ± 2.12 vs. 4.44 ± 2.06, p = 0.818; IgG 11.76 ± 6.09 vs. 8.77 ± 4.65, p = 0.047) in patients with sporadic non-developed pregnancy compared to women without reproductive loss, while in patients with habitual unbearable pregnancy the values were comparable for antibodies to estradiol (IgA 11.76 ± 6.09 vs. 3.26 ± 1.69, p = 0.749; IgG 8.12 ± 6.28 vs 7.08 ± 4.06, p = 0.749), progesterone (IgA 2.79 ± 1.163 vs 2.29 ± 1.17, p = 0.229; IgG 2.79 ± 1.163 vs. 5.48 ± 3.65, p = 0.573) and pyrene-free (IgA 4.65 ± 2.57 vs. 4.44 ± 2.06, p = 0.749; IgG 8.76 ± 6.19 vs. 8,77 ± 4,65, p = 0.994).

Keywords

non-developing pregnancy, estradiol, progesterone, benzo(a)pyrene, antibodies

Author Biographies

Гюлай Агамуса кызы Сафарова,
postgraduate student, department of obstetrics and gynecology of further professional education
Марина Борисовна Игитова,
doctor of medical sciences, professor of the department of obstetrics and gynecology of further professional education
Юрий Владимирович Кореновский,
candidate of medical sciences, docent, head of the department of general and biological chemistry, clinical laboratory diagnostics
Елена Геннадьевна Поленок,
candidate of pharmacological sciences, head of the laboratory of immunochemistry

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
© Гюлай Агамуса кызы Сафарова, Марина Борисовна Игитова, Юрий Владимирович Кореновский, Елена Геннадьевна Поленок, 2020


Creative Commons License  This work is licensed under a Creative Commons Attribution 4.0 License.

How to Cite

Сафарова, Г. А. к., Игитова, М. Б., Кореновский, Ю. В., & Поленок, Е. Г. (2020). ANTIBODIES TO BENZO(A)PYRENE AND STEROID HORMONES IN WOMEN WITH NON-DEVELOPING PREGNANCY. Mother and Baby in Kuzbass, 21(2), 44-47. https://doi.org/10.24411/2686-7338-2020-10021

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