PREGNANT PHYTOTHERAPY AND REHABILITATION OF PATIENTS AFTER EARLY REPRODUCTIVE LOSSES
Main Article Content
Abstract
The aim of the study – to evaluate the clinical efficacy and safety of a combination of phytopharmaceuticals from local Altai raw materials as a rehabilitation therapy and preconception preparation in patients after an unviable pregnancy/early sporadic miscarriage.
Materials and methods. A prospective open-label observational study was conducted in a group of patients of reproductive age (n = 39) who had experienced early reproductive loss before 9.6 weeks of gestation, before and after a 15-day course of rehabilitation with GynecoNorm phytophytocapsules taken orally in combination with Gynecozol vaginal suppositories as part of preconception preparation after an initial examination. The effectiveness was evaluated after 1, 3, 6 months by studying the morphofunctional potential of the endometrium based on ultrasound data during the II phase of the menstrual cycle, the condition of the vaginal biotope (pH, smear microscopy), and the realization of reproductive function.
Results and discussion. After the course of phytotherapy, a significant improvement in the endometrial condition (an increase of >2 mm) was observed in 65.2% of patients (p = 0.028), with an average increase in M-echo of 2.2 ± 0.1 mm. The frequency of severe vaginal dysbiosis decreased from 33.3% to 5.1% (p = 0.005). Six months after the study, pregnancy occurred in 15.4% of patients.
Conclusion. The combined course of pre-conception preparation with Altai phyto-complexes demonstrated high efficiency in restoring the morphofunctional potential of the endometrium and vaginal biotope, which is a key factor for successful conception. The proposed scheme is safe, well-tolerated, and can be recommended for implementation in practice as a component of a rehabilitation program after early reproductive losses.
Keywords
Author Biographies
Olga Vasilievna Remneva,
Olga V. Remnyova
MD, PhD, professor. Head of the Department of Obstetrics and Gynecology. The doctor is an obstetrician-gynecologist of the highest category, the organizer of healthcare of the first category.
Olga Aleksandrovna Belnitskaya,
candidate of medical sciences, docent, docent of the department of obstetrics and gynecology with continuing professional education course N 1
Tatyana Ivanovna Gorbacheva,
candidate of medical sciences, docent, docent of the department of obstetrics and gynecology with continuing professional education course N 1
Irina Vladimirovna Pyankova,
candidate of medical sciences, docent of the department of obstetrics and gynecology with continuing professional education course N 1
Nadezhda Vladimirovna Zaykina,
clinical resident of the department of obstetrics and gynecology with continuing professional education course N 1
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Pregravid preparation. Clinical protocol of the Interdisciplinary Association of Reproductive Medicine Specialists (MARS). Version 3.1 / [A team of authors]. Moscow: StatusPraesens, 2024: 124 p. Russian. (Прегравидарная подготовка. Клинический протокол Междисциплинарной ассоциации специалистов репродуктивной медицины (МАРС). Версия 3.1 / [Коллектив авторов]. М.: Редакция журнала StatusPraesens, 2024. 124 с.)
Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, Brosens JJ, Brewin J, Ramhorst R, Lucas ES, McCoy RC, Anderson R, Daher S, Regan L, Al-Memar M, Bourne T, MacIntyre DA, Rai R, Christiansen OB, Sugiura-Ogasawara M, Odendaal J, Devall AJ, Bennett PR, Petrou S, Coomarasamy A. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. Lancet. 2021; 397(10285):1658-1667. doi: 10.1016/S0140-6736(21)00682-6
Kuzmina EA, Orazmuradov AA, Suleymanova ZhZh, Bekbaeva IV, Apresyan AA, Akhmatova AN, Orazmuradova AA. Risk factors for early pregnancy loss in women with obesity. Fundamental and Clinical Medicine. 2025; 10(1):39-46. Russian (Кузьмина Е.А., Оразмурадов А.А., Сулейманова Ж.Ж., Бекбаева И.В., Апресян А.А., Ахматова А.Н., Оразмурадова А.А. Факторы риска неразвивающейся беременности у женщин с ожирением // Фундаментальная и клиническая медицина. 2025. №10(1). С. 39-46.) doi:10.23946/2500-0764-2025-10-1-39-46
Kutsenko II, Borovikov IO, Kravtsova EI, Bulgakova VP, Borovikova OI, Cheremnykh RV, Andreeva AA, Borovikov MI. Vaginal and endometrial microbiome: evaluation, effect on embryo implantation. Medical Herald of the South of Russia. 2023;14(3):5-15. Russian (Куценко И.И., Боровиков И.О., Кравцова Е.И. Булгакова В.П., Боровикова О.И., Черемных Р.В., Андреева А.А., Боровиков М.И. Вагинальный и эндометриальный микробиом: оценка, влияние на имплантацию эмбриона // Медицинский вестник Юга России. 2023. №14(3). С. 5-15.) doi:10.21886/2219-8075-2023-14-3-5-15
Przybylski M, Wicher-Gozdur I, Kippen J, Millert-Kalinska S, Zawiejska A, Jach R, Pruski D. Effect of Ureaplasma/Mycoplasma genital tract infection on preterm labor. Ginekol. Pol. 2024; 95(12):959-965. doi: 10.5603/gpl.99827
Dobrokhotova YuE, Bondarenko KR, Shadrova PA. Current view on infectious factor of early reproductive losses and possible pathogenetic mechanisms. Russian Journal of Human Reproduction. 2020;26(3):23‑30. Russian (Доброхотова Ю.Э., Бондаренко К.Р., Шадрова П.А. Современный взгляд на инфекционный фактор и возможные патогенетические механизмы ранних репродуктивных потерь // Проблемы репродукции. 2020. №26(3). С. 23-30.) doi: 10.17116/ repro20202603123
Shabanova AA, Shitova MS. Habitual Miscarriage: A Modern Perspective on the Problem. Stolypinsky Bulletin. 2022;3. (accessed: 14.12.2025). Russian (Шабанова А.А., Шитова М.С. Привычное невынашивание беременности - современный взгляд на проблему // Научный сетевой журнал «Столыпинский вестник». 2022. №3. URL: https://cyberleninka.ru/article/n/privychnoe-nevynashivanie-beremennosti-sovremennyy-vzglyad-na-problemu/viewer (дата обращения 14.12.2025)
Bektemirova DR, Romanova ZhV, Duschpanova AT. Non-Developing Pregnancy: Main Abortive Causes. (Literature Review). Bulletin of KazSMU. 2021; 2: 25-32. Russian (Бектемирова Д.Р., Романова Ж.В., Душпанова А.Т. Неразвивающаяся беременность: основные абортивные причины (обзор литературы) // Вестник КазГМУ. 2021. №2. С. 25-32.) doi: 10.530657 KAZNMU.2021.93.53.004
Fang Z, Huang J, Mao J, Yu L, Wang X. Effect of endometrial thickness on obstetric and neonatal outcomes in assisted reproduction: a systematic review and meta-analysis. Reprod. Biol. Endocrinol. 2023; 21(1):55. doi: 10.1186/s12958-023-01105-6
Gynecology. Pharmacotherapy without Errors. A Guide for Doctors / Edited by Sukhikh GT, Serov VN, Prilepskaya VN, Baranov II. Moscow: E-noto, 2020: 544 p. Russian. (Гинекология. Фармакотерапия без ошибок. Руководство для врачей / под ред. Г.Т. Сухих, В.Н. Серова, В.Н. Прилепской, И.И. Баранова. М.: Е-ното, 2020. 544 с.)
Botoeva EA, Anikeeva TG. Role of phytotherapy in obstetrics and gynecology. Bulletin of Buryat State University. Medicine and Pharmacy. 2019; 1: 53-57. Russian (Ботоева Е.А., Аникеева Т.Г. Роль фитотерапии в акушерстве и гинекологии // Вестник Бурятского государственного университета. Медицина и фармация. 2019. №1. С. 53-57.) doi: 10.18101/2306-1995-2019-1-53-57
Umbetali AO, Nurlanova AA, Ustenova GO. Application of medicinal plants orthilia secunda in the treatment of gynecological diseases. Bulletin of KazSMU. 2019; 1: 488-489. Russian (Умбетали А.О., Нурланова А.А., Устенова Г.О. Применение лекарственного растения ортилии однобокой (orthilia secunda) в лечении гинекологических заболеваний // Вестник КазГМУ. 2019. №1. С. 488-489.)
Chernova AE, Remneva OV, Baranov DA, Grebtsov IV, Petrov AV, Shadeeva YuA. Infectious and inflammatory factor in the genesis of late spontaneous miscarriages and correction by natural physical factors. Bulletin of Medical Science. 2024; 4 (36): 68-76. Russian (Чернова А.Е., Ремнева О.В., Баранов Д.А., Гребцов И.В., Петров А.В., Шадеева Ю.А. Инфекционно-воспалительный фактор в генезе поздних самопроизвольных выкидышей и его коррекция природными физическими факторами // Бюллетень медицинской науки. 2024. № 4 (36). С. 68-76.) doi.10.23946/2500-0764-2025-10-1-39-46