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Алена Владимировна Ведерникова
Юрий Иванович Ровда
Василий Витальевич Дадонов
Наталья Николаевна Миняйлова
Ольга Валерьевна Шмакова
Татьяна Сергеевна Хоботкова
Наталья Степановна Черных
Александра Николаевна Деменова
Анна Андреевна Лобыкина

Abstract

Modern medicine is faced with one of the most serious threats to human health – antibiotic resistance. According to the World Health Organization (WHO), by 2050, antibiotic resistance in microorganisms could cause more than 10 million deaths annually, surpassing even cancer in terms of its consequences [World Health Organization (WHO), 2019].
This phenomenon not only undermines the effectiveness of modern antibiotic therapy, but also threatens advances in the treatment of infectious diseases, surgery, pediatrics, and other areas of medicine where antibacterial drugs play a key role.

Keywords

antibiotic resistance, macroorganism, pharmacokinetics, metabolism, drug interactions, P-glycoprotein, cytochrome P450

Author Biographies

Алена Владимировна Ведерникова,
senior lecturer of the department of pediatrics and neonatology
Юрий Иванович Ровда,
doctor of medical sciences, professor, professor of the department of pediatrics and neonatology
Василий Витальевич Дадонов,
student of the faculty of pediatrics
Наталья Николаевна Миняйлова,
doctor of medical sciences, docent, professor of the department of pediatrics and neonatology
Ольга Валерьевна Шмакова,
candidate of medical sciences, docent, head of the department of pediatrics and neonatology
Татьяна Сергеевна Хоботкова,
candidate of medical sciences, assistant of the department of pediatrics and neonatology
Наталья Степановна Черных,
candidate of medical sciences, docent, docent of the department of polyclinic pediatrics, propaedeutics of childhood diseases and postgraduate training
Александра Николаевна Деменова,
resident of the department of pediatrics and neonatology
Анна Андреевна Лобыкина,
assistant of the department of pediatrics and neonatology

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.

How to Cite

Ведерникова, А. В., Ровда, Ю. И., Дадонов, В. В., Миняйлова, Н. Н., Шмакова, О. В., Хоботкова, Т. С., Черных, Н. С., Деменова, А. Н., & Лобыкина, А. А. (2025). ANTIBIOTIC RESISTANCE: THE ROLE OF SYSTEMIC MECHANISMS OF THE MACROORGANISM AND THEIR ABILITY TO DETERMINE THE INSUFFICIENT EFFECTIVENESS OF DRUGS (LITERATURE REVIEW). Mother and Baby in Kuzbass, 26(3), 17-22. https://doi.org/10.24412/2686-7338-2025-3-17-22

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