Main Article Content
Abstract
The aim of the research – to study the prevalence of vitamin D deficiency in girls and boys – students of the Republic of Bashkortostan.
Materials and methods. A study of the reproductive potential of girls and boys aged 15-19 years was carried out. There were 480 girls and 126 boys examined. All students were divided into age subgroups: girls 15-17 years old – 217 people, 18-19 years old – 263; boys 15-17 years old – 76 people, 18-19 years old – 50 surveyed. Blood serum was analyzed for the content of 25(OH)D based on the Roche Cobas 8000 automated modular platform with the e801 immunochemical module. Statistical processing is provided by the Statistica program.
Results. This study showed that 62.9% of all surveyed girls have vitamin D deficiency of varying severity, and only 1/3 of the female students had prohormone D levels in their blood plasma at an adequate level and amounted to 37.1% (p1 < 0.0001). If we compare the age group of 15-17 and 18-19-year-old girls with a deficiency of this nutrient, which is 65% and 61.2%, respectively, statistical significance between the subgroups was also revealed (p < 0.05). As for the boys examined, they had vitamin D deficiency of varying severity in 78.6% of cases. And just like in girls, in the younger age subgroup, the deficiency of this nutrient is more pronounced and accounts for 85.5% of the total number (76) of the surveyed boys.
Conclusion. To make up for the lack of vitamin D, it is preferable to follow the Mediterranean diet, which includes foods rich in calciferols. At the same time, subsidies for cholecalciferol in the form of drugs or dietary supplements are needed in accordance with the recommendations of the Russian Association of Endocrinologists. In addition, it is proposed to determine the level of 25(OH)D in the blood serum of women planning pregnancy, in order to adjust the dose of vitamin D.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Holick MF. Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need? Adv Exp Med Biol. 2020; 1268: 19-36. doi: 10.1007/978-3-030-46227-7_2
Mavar M, Sorić T, Bagarić E, Sarić A, Matek Sarić M. The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans? Nutrients. 2024; 16(8): 1176. doi: 10.3390/nu16081176
Chen B, Ji P, Wang Q, Qin W, Li Z. Vitamin D levels and its influencing factors in pregnant women in mainland China: A systematic review and meta-analysis. PLoS One. 2024; 19(5): e0297613. doi: 10.1371/journal.pone.0297613
Cunningham TK, Allgar V, Dargham SR, Kilpatrick E, Sathyapalan T, Maguiness S, et al. Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment. Front Endocrinol (Lausanne). 2019; 10: 13. doi: 10.3389/fendo.2019.00013
Muscogiuri G, Altieri B, de Angelis C, Palomba S, Pivonello R, Colao A, Orio F. Shedding new light on female fertility: The role of vitamin D. Rev Endocr Metab Disord. 2017; 18(3): 273-283. doi: 10.1007/s11154-017-9407-2
Skoracka K, Ratajczak AE, Rychter AM, Dobrowolska A, Krela-Kaźmierczak I. Female Fertility and the Nutritional Approach: The Most Essential Aspects. Adv Nutr. 2021; 12(6): 2372-2386. doi: 10.1093/advances/nmab068
Carlberg C. Vitamin D: A Micronutrient Regulating Genes. Curr Pharm Des. 2019; 25(15): 1740-1746. doi: 10.2174/1381612825666190705193227
Gao B, Zhang C, Wang D, Li B, Shan Z, Teng W, Li J. Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study. J Ovarian Res. 2024; 17(1): 95. doi: 10.1186/s13048-024-01420-5
Ko JKY, Yung SSF, Lai SF, Wan RSF, Wong CKY, Wong K, et al. Effect of vitamin D in addition to letrozole on the ovulation rate of women with polycystic ovary syndrome: protocol of a multicentre randomised double-blind controlled trial. BMJ Open. 2024; 14(4): e070801. doi: 10.1136/bmjopen-2022-070801
Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L, Zhang J. Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023; 14: 1148556. doi: 10.3389/fendo.2023.1148556
Jafari M, Khodaverdi S, Sadri M, Moradi Z, Mohammadi T, Heidari S, et al. Association Between Vitamin D Receptor (VDR) and Vitamin D Binding Protein (VDBP) Genes Polymorphisms to Endometriosis Susceptibility in Iranian Women. Reprod Sci. 2021; 28(12): 3491-3497. doi: 10.1007/s43032-021-00598-z
Becker S, Cordes T, Diesing D, Diedrich K, Friedrich M. Expression of 25 hydroxyvitamin D3-1alpha-hydroxylase in human endometrial tissue. J Steroid Biochem Mol Biol. 2007; 103(3-5): 771-775. doi: 10.1016/j.jsbmb.2006.12.075
Bergadà L, Pallares J, Vittoria AM, Cardus A, Santacana M, Valls J, et al. Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma. Lab Invest. 2014; 94(6): 608-622. doi: 10.1038/labinvest.2014.57
Barrera D, Avila E, Hernández G, Méndez I, González L, Halhali A, et al. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reprod Biol Endocrinol. 2008; 6: 3. doi: 10.1186/1477-7827-6-3
Farhangnia P, Noormohammadi M, Delbandi AA. Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis. Reprod Health. 2024; 21(1): 61. doi: 10.1186/s12978-024-01797-y
Chudinin NV, Rakitina IS, Dementiev AA. Nutrient Composition of the Diet of Junior Students of a Medical University. Population health and habitat. 2020; 2(323): 16-20. Russian (Чудинин Н.В., Ракитина И.С., Дементьев А.А. Нутриентный состав питания студентов младших курсов медицинского вуза //Здоровье населения и среда обитания. 2020. № 2(323). С. 16-20.) doi: 10.35627/2219-5238/2020-323-2-16-20
Kodentsova VM, Beketova NA, Nikityuk DB, Tutelyan VA. Characteristics of vitamin provision in the adult population of the Russian Federation. Russian Journal of Preventive Medicine. 2018; 21(4): 32 37. Russian (Коденцова В.М., Бекетова Н.А., Никитюк Д.Б., Тутельян В.А. Характеристика обеспеченности витаминами взрослого населения Российской Федерации //Профилактическая медицина. 2018. Т. 21, № 4. С. 32-37.) doi: 10.17116/profmed201821432
Suplotova L.A., Avdeeva V.A., Rozhinskaya L.Y., Pigarova E.A., Troshina E.A. Analysis of risk factors for vitamin D deficiency by results of the first stage of Russian non-interventional register study. Medical Council. 2021; 7: 109-118. Russian (Суплотова Л.А., Авдеева В.А., Рожинская Л.Я., Пигарова Е.А., Трошина Е.А. Анализ факторов риска дефицита витамина D по результатам первого этапа российского неинтервенционного регистрового исследования //Медицинский совет. 2021. № 7. С. 109-118.) doi: 10.21518/2079-701X-2021-7-109-118