Main Article Content

Наталья Александровна Жданова
Алла Дмитриевна Алексеева
Ирина Владимировна Болгова
Марина Николаевна Ляхова
Елена Владимировна Рудаева
Светлана Ивановна Елгина
Кира Борисовна Мозес
Наталья Степановна Черных
Елена Германовна Рудаева
Яэль Центер

Abstract

Short stature in children is an urgent problem, while pediatricians underestimate the information content of anthropometric indicators, as a result of which a number of endocrine and non-endocrine diseases accompanied by growth retardation are diagnosed late. The article presents a clinical case of growth hormone treatment of a child with short stature of mixed origin. Attention is focused on diagnosis and modern principles of replacement therapy. In recent decades, with timely detection, this pathology can be treated quite successfully. Currently, the list of nosologies for which the use of recombinant growth hormone is possible has been significantly expanded, and the task of a pediatrician is to conduct anthropometric and laboratory screening of patients with short stature for subsequent referral to a pediatric endocrinologist and geneticist.

Keywords

short stature, genetic causes, anthropometry, clinical diagnosis, replacement therapy

Author Biographies

Наталья Александровна Жданова,
pediatric endocrinologist
Алла Дмитриевна Алексеева,
pediatric endocrinologist
Ирина Владимировна Болгова,
head of the children's clinic
Марина Николаевна Ляхова,
head of the pediatric department
Елена Владимировна Рудаева,
candidate of medical sciences, docent, docent of the department of obstetrics and gynecology named after G.A. Ushakova
Светлана Ивановна Елгина,
doctor of medical sciences, docent, professor of the department of obstetrics and gynecology named after G.A. Ushakova
Кира Борисовна Мозес,
assistant, department of polyclinic therapy and nursing
Наталья Степановна Черных,
candidate of medical sciences, docent, docent of the department of polyclinic pediatrics, propaedeutics of childhood diseases and postgraduate training
Елена Германовна Рудаева,
candidate of medical sciences, docent, docent of the department of childhood diseases
Яэль Центер,
pathologist

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.

How to Cite

Жданова, Н. А., Алексеева, А. Д., Болгова, И. В., Ляхова, М. Н., Рудаева, Е. В., Елгина, С. И., Мозес, К. Б., Черных, Н. С., Рудаева, Е. Г., & Центер, Я. (2024). RESULTS OF TREATMENT WITH GROWTH HORMONE IN A CHILD WITH STORTING OF MIXED GENESIS (CLINICAL CASE). Mother and Baby in Kuzbass, 25(1), 101-104. https://doi.org/10.24412/2686-7338-2024-1-101-104

References

Baron J, Sävendahl L, De Luca F, Dauber A, Phillip M, Wit JM, Nilsson O. Short and tall stature: a new paradigm emerges. Nat Rev Endocrinol. 2015; 11(12): 735-746. DOI: 10.1038/nrendo.2015.165

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017; 542(7640): 186-190. DOI: 10.1038/nature21039

Atanesyan RA, Klimov LYa, Uglova TA, Vdovina TM, Semenova TB, Stoian MV, et al. Short stature in children and adolescents: diagnostic algorithm and modern treatment options. Pediatrics. Appendix to the journal Consilium Medicum. 2017; 1: 103-108. Russian (Атанесян Р.А., Климов Л.Я., Углова Т.А., Вдовина Т.М., Семенова Т.Б., Стоян М.В., и др. Низкорослость у детей и подростков: диагностический алгоритм и современные возможности терапии //Педиатрия. Приложение к журналу Consilium Medicum. 2017. № 1. С. 103-108)

Endocrine diseases in children and adolescents: a guide for doctors /EB Bashnina (ed.). M.: GEOTAR-Media, 2017. 416 p. Russian (Эндокринные заболевания у детей и подростков: руководство для врачей /Е.Б. Башнина (ред.). М.: ГЭОТАР-Медиа, 2017. 416 с.)

Jee YH, Andrade AC, Baron J, Nilsson O. Genetics of Short Stature. Endocrinol Metab Clin North Am. 2017; 46(2): 259-281. DOI: 10.1016/j.ecl.2017.01.001

Nilsson O, Weise M, Landman EB, Meyers JL, Barnes KM, Baron J. Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits. Endocrinology. 2014; 155(8): 2892-2899. DOI: 10.1210/en.2013-2175

Murray PG, Clayton PE, Chernausek SD. A genetic approach to evaluation of short stature of undetermined cause. Lancet Diabetes Endocrinol. 2018; 6(7): 564-574. DOI: 10.1016/S2213-8587(18)30034-2

Gkourogianni A, Andrew M, Tyzinski L, Crocker M, Douglas J, Dunbar N, et al. Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations. J Clin Endocrinol Metab. 2017; 102(2): 460-469. DOI: 10.1210/jc.2016-3313

Hauer NN, Sticht H, Boppudi S, Büttner C, Kraus C, Trautmann U, et al. Genetic screening confirms heterozygous mutations in ACAN as a major cause of idiopathic short stature. Sci Rep. 2017; 7(1): 12225. DOI: 10.1038/s41598-017-12465-6

Hisado-Oliva A, Ruzafa-Martin A, Sentchordi L, Funari MFA, Bezanilla-López C, Alonso-Bernáldez M, et al. Mutations in C-natriuretic peptide (NPPC): a novel cause of autosomal dominant short stature. Genet Med. 2018; 20(1): 91-97. DOI: 10.1038/gim.2017.66

Grimberg A, Allen DB. Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence. Curr Opin Pediatr. 2017; 29(4): 466-471. DOI: 10.1097/MOP.0000000000000505

Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT. Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center. Acta Biomed. 2020; 91(1): 29-40. DOI: 10.23750/abm.v91i1.9182

Downloads

Download data is not yet available.

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>