МЕХАНИЗМЫ ФОРМИРОВАНИЯ ВТОРИЧНОЙ ИММУНОЛОГИЧЕСКОЙ НЕДОСТАТОЧНОСТИ ПРИ ТЯЖЕЛОЙ ЧЕРЕПНО-МОЗГОВОЙ ТРАВМЕ


Борщикова Т.И., Епифанцева Н.Н., Кан С.Л., Додонов М.В., Филимонов С.Н.

Аннотация


В статье представлен обзор патофизиологических механизмов формирования вторичной иммунологической недостаточности при тяжелой черепно-мозговой травме: стресс-индуцированное изменение функционирования нейрогуморальной оси, увеличение уровней катехоламинов, цитокинов, активация апоптоза лимфоидных клеток.


Ключевые слова


тяжелая черепно-мозговая травма; системная воспалительная реакция; иммуносупрессия; цитокины; апоптоз

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Литература


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