RELATIONSHIP OF LIPID PROFILE AND IMMUNE STATUS IN THE DYNAMICS OF LONG-TERM EXPOSURE TO COAL-ROCK DUST ON THE BODY (EXPERIMENTAL STUDIES)
Main Article Content
Abstract
Subject. The relationship between lipid metabolism and immune reactivity in the dynamics of long-term exposure to coal-rock dust (CRD) on the body.
Objective. In the experiment to examine the impact of the changes in the lipid profile on immune status under the conditions of long-term exposure to CRD on the body.
Methods. The experiments were carried out on 110 white male rats weighing 200-250 g. The inhalation method was used for modeling that best fits the conditions of coal-mine production. Animals were divided into 2 groups: the control (n = 30); the experiment (n = 80), that are the rats who inhaled CRD with a particle size of up to 5 microns in an average concentration of 50 mg/m3 for 4 hours daily for 12 weeks.
Main results. Early terms of the CRD impact are characterized by the activation of the immune system against the background of metabolic shifts as well as by morphological changes of the immune nature in the bronchopulmonary system and liver of the rats that can be regarded as compensatory-adaptive. Prolonged exposure to the dust factor leads to an increase in dyslipidemia, which contributes to the development of immune imbalance as well as morphological changes that are indicative of the chronic inflammation and disturbance of compensatory mechanisms.
Field of application. The results of the conducted experimental studies broaden the fundamental ideas about the mechanisms of immune body defense. The detection of pathogenetic mechanisms underlying the formation and course of occupational diseases allows assessing the functional state of the organism at the stage of pre-existing disease, revealing the initial signs of developing pathology and determining the ways of their correction.
Conclusions. CRD intake is characterized by the development of metabolic changes, which are closely related to immune reactivity. An integrated approach to the study of occupational and industrially-caused pathology makes it possible to assess the functional state of the organism at the early stages of the disease development and to substantiate diagnostic markers for determining the state of pre-existing disease and for conducting timely preventive measures.
Keywords
Author Biographies
Анастасия Сергеевна Казицкая,
канд. биол. наук, ст. науч. сотрудник, лаборатория популяционной генетикиАнна Геннадьевна Жукова,
Zhukova Anna Gennadyevna
doctor of biology, professor, head of the laboratory of population genetics, Research Institute for Complex Problems of Hygiene and Occupational Diseases; professor of the chair for natural science disciplines and teaching methods, Novokuznetsk Institute (Branch) of the Kemerovo State University, Novokuznetsk
Мария Сергеевна Бугаева,
канд. биол. наук, науч. сотрудник, научно-исследовательская лаборатория патологической анатомииНаталья Николаевна Жданова,
соискательArticle Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Artamonova VG, Lashina EL. Prognosis of professional diseases of respiratory organs and their prophylaxis. Medical Academic Journal. 2006; 6(1): 63-68. Russian (Артамонова В.Г., Лашина Е.Л. Прогнозирование профессиональных заболеваний органов дыхания и пути их профилактики //Медицинский академический журнал. 2006. Т. 6, № 1. С. 63-68)
Izmerov NF. Modern problems of occupational medicine in Russia. Occupational medicine and human ecology. 2015; (2): 5-12. Russian (Измеров Н.Ф. Современные проблемы медицины труда России //Медицина труда и экология человека. 2015. № 2(2). С. 5-12)
Piktoushanskaya TE. Contemporary features of pneumoconiosis formation and course in miners of East Donbass. Occupational medicine and industrial ecology. 2014; (2): 10-14. Russian (Пиктушанская Т.Е. Особенности формирования и течения пневмокониоза у шахтеров Восточного Донбасса в современных условиях //Медицина труда и промышленная экология. 2014. № 2. С. 10-14)
Shpagina LA, Poteryaeva EL, Kotova OS, Shpagin IS, Smirnova EL. Topical problems of pulmonology in contemporary occupational medicine. Occupational medicine and industrial ecology. 2015; (9): 11-14. Russian (Шпагина Л.А., Потеряева Е.Л., Котова О.С., Шпагин И.С., Смирнова Е.Л. Актуальные проблемы пульмонологии в современной профпатологической клинике //Медицина труда и промышленная экология. 2015. № 9. С. 11-14)
Panev NI, Zakharenkov VV, Safina VP, Gerasimova GA, Kurganskaya NP, Yagnyukova NV et al. Disturbance of lipid metabolism in the combination of atherosclerosis with occupational dust pulmonary pathology. In: Actual problems of occupational medicine : the materials of the XL Interregional scientific and practical conference with international participation, Novokuznetsk, September 12-13, 2005. Zakharenkov VV, editor. Novokuznetsk, 2005. p. 39-43. Russian (Панев Н.И., Захаренков В.В., Сафина В.П., Герасимова Г.А., Курганская Н.П., Ягнюкова Н.В. и др. Нарушения липидного обмена при сочетании атеросклероза с профессиональной пылевой патологией легких //Актуальные проблемы медицины труда: матер. XL Межрегион. науч.-практ. конф. с междунар. участием, г. Новокузнецк, 12-13 сентября 2005 г. /под ред. В.В. Захаренкова. Новокузнецк, 2005. С. 39-43)
Nagornev VA, Yakovleva OA, Maltseva SV. Atherogenesis as a reflection of the development of immune inflammation in the vascular wall. Herald of the Russian Academy of Medical Sciences. 2000; (10): 45-50. Russian (Нагорнев В.А., Яковлева О.А., Мальцева С.В. Атерогенез как отражение развития иммунного воспаления в сосудистой стенке //Вестник Российской академии медицинских наук. 2000. № 10. С. 45-50)
Pokrovskaya EV. Atherosclerosis and immune system (workshop of the European Atherosclerosis Society). Cardiology. 2001; 41(10): 69-73. Russian (Покровская Е.В. Атеросклероз и иммунная система (по материалам семинара Европейского общества атеросклероза) //Кардиология. 2001. Т. 41, № 10. С. 6973)
Fomenko DV, Ulanova EV, Zoloeva PV, Zakharenkov VV, Burdein AV, Panev NI. Clinical and experimental research of metabolic changes in an organism at long-term inhalation of coal-rock dust. Siberian Scientific Medical Journal. 2010; 30(1): 117-122. Russian (Фоменко Д.В., Уланова Е.В., Золоева П.В., Захаренков В.В., Бурдейн А.В., Панев Н.И. Клинико-экспериментальное исследование метаболических изменений организма при длительном вдыхании угольно-породной пыли //Сибирский научный медицинский журнал. 2010. Т. 30, № 1. С. 117-122)
Khlyustov VN, Abidov MT, Goncharuk AV. Immunomorphological aspects of the atherosclerosis pathogenesis and algorithms of immunomodulating therapy. Advances in contemporary natural science. 2005; (12): 58-61. Russian (Хлюстов В.Н., Абидов М.Т., Гончарук А.В. Иммуноморфологические аспекты патогенеза атеросклероза и алгоритмы иммуномодулирующей терапии //Успехи современного естествознания. 2005. № 12. С. 58-61)
Popkova OV, Kudaeva IV. The influence of mercury on the development of endothelial dysfunction. Actual problems of humanitarian and natural sciences. 2015; (11-7): 79-82. Russian (Попкова О.В., Кудаева И.В. Влияние ртути на развитие эндотелиальной дисфункции //Актуальные проблемы гуманитарных и естественных наук. 2015. № 11-7. С. 79-82)
Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. Cell. Physiol. 2001: 280(4): 719-741