ОСНОВНЫЕ ВНУТРИКЛЕТОЧНЫЕ МЕХАНИЗМЫ ФОРМИРОВАНИЯ МОРФОЛОГИЧЕСКИХ ИЗМЕНЕНИЙ ВНУТРЕННИХ ОРГАНОВ ПРИ ФЛЮОРОЗЕ (ОБЗОР ЛИТЕРАТУРЫ)


Бугаева М.С., Бондарев О.И.

Аннотация


Хроническая интоксикация соединениями фтора остается серьезной проблемой общественного здравоохранения несмотря на снижение их концентрации на производстве и общего уровня заболеваемости в последние годы. Длительное воздействие микроэлемента и его способность накапливаться в организме являются решающими факторами в морфогенезе структурных сдвигов. Поскольку основным проявлением флюороза является поражение зубов и скелета, исследователи традиционно сосредотачивают свое внимание на изучении преимущественно патологии данных тканей. В то же время, за последние годы накопился большой объем работ, посвященных действию фтора на нескелетные органы.

В данном обзоре представлен анализ текущих исследований морфологических аспектов воздействия фторидов на внутренние органы. Показано, что длительное воздействие и аккумуляция в организме соединений фтора приводят к системным внутриклеточным нарушениям: повышению уровня активных форм кислорода и азота, активации свободно-радикального окисления, модуляции путей внутриклеточной сигнализации и программируемой гибели клеток. Указанные патологические процессы опосредуют формирование морфологических изменений и функциональную несостоятельность как опорно-двигательного аппарата, так и нескелетных тканей, что требует комплексного подхода к лечению фтористой интоксикации и методам ее профилактики.


Ключевые слова


флюороз; морфологические изменения; свободно-радикальное окисление; апоптоз; внутриклеточные сигнальные пути; обзор

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