FUNCTIONAL STATUS OF METABOLIC COMPONENT OF CELLULAR ENERGY METABOLISM BY COMMUNITY-ACGUIRED PNEUMONIA IN CHILDREN WITH PERINATAL AFFECTION OF CNS
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Abstract
The aim of this study – to investigate the characteristics of the functional state of the metabolic level of cell energy metabolism in uncomplicated and complicated community-acquired pneumonia in children with perinatal CNS involvement.
Materials and methods. There were examined 87 children aged from 6 months to 3 years with community-acquired pneumonia (CAP) and associated CNS involvement. The patients were divided into 2 groups. The I group consisted of 44 children (56,6 %) with complicated course of CAP. The II group consisted of 43 patients (49,4 %) with uncomplicated pneumonia. Under the data of content of lactate and pyruvate in blood there was determined the character of disorders of metabolic level of cell energy metabolism. The automated biochemical analyzer COBAS INTEGRA 400 plus and a spectrophotometer PE-5300 VI were used in the study.
Results and their discussion. The average values of the content of lactate and pyruvate in blood and determination of their ratio in patients in both groups showed that the greatest coefficient value (20,4 ± 0,72) was among children with perinatal CNS involvement, who had the severe complicated course the pneumonia. In the group of patients with uncomplicated CAP course test cvharacteristic was 16.2 ± 0,49 (p < 0.001) and in the control group – 9.8 ± 0,30.
Conclusion. In complicated pneumonia dominant metabolism is anaerobic glycolysis indicating decompensation of energy homeostasis of patients` body, as well as attributable to them expressed metabolic disorders in form of lactat acid acidosis along with hypoxemia, hypercapnia.
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Community-acquired pneumonia in children. Clinical recommendations. M.: Layout original, 2015. 64 p. Russian (Внебольничная пневмония у детей. Клинические рекомендации. М.: Оригинал-макет, 2015. 64 с.)
Geppe NA, Malakhov AB, Volkov IK, Kozlova LV, Dronov IA. On the issue of the further development of the scientific and practical program on community-acquired pneumonia in children. Russkij medicinskij zhurnal. 2014; 22(3):188-193. Russian (Геппе Н.А., Малахов А.Б., Волков И.К., Козлова Л.В., Дронов И.А. К вопросу о дальнейшем развитии научно-практической программы по внебольничной пневмонии у детей //Русский медицинский журнал. 2014. Т. 22, № 3. С. 188-193)
Tatochenko VK. Diseases of the respiratory system in children: a practical guide. M.: «Pediatric», 2012. 480 p. Russian (Таточенко В.К. Болезни органов дыхания у детей: практическое руководство. М.: «ПедиатрЪ», 2012. 480 с.)
Zar HJ, Madhi SA, Aston SJ, Gordon SB. Pneumonia in low and middle income countries: progress and challenges. Thorax. 2013; 68: 1052-1056
Leung DT, Chisti MJ, Pavia AT. Prevention and Control of Childhood Pneumonia and Diarrhea. Pediatr. Clin. N. Am. 2016; 63: 67-79
Esposito S, Patria MF, Tagliabue C et al. CAP in children. European Respiratory Monograph 63: Community-Acquired Pneumonia. 2014. P. 130-139
Kondratova IYu. The role of cell energy metabolism in pathogenesis of complicated pneumonia in infants: cand. med. sci. abstracts diss. Kharkiv, 2010. 20 p. Ukrainian (Кондратова І.Ю. Роль клітинного енергетичного обміну у патогенезі ускладненого перебігу пневмонії у дітей першого року життя: автореф. дис. … канд. мед. наук. Харків, 2010. 20 с.)
Senatorova AS, Kondratova IYu, Omelchenko EV. Violation of energy metabolism in pediatric practice. Children doctor. 2013; 7-8: 9-16. Ukrainian (Сенаторова А.С., Кондратова И.Ю., Омельченко Е.В. Нарушение энергетического обмена в практике педиатра //Дитячий лікар. 2013. № 7-8. С. 9-16)
Senatorova AS, Kondratova IYu Sukhorukov VS. Energy deficiency states as a risk factor for complicated course of pneumonia in children of the first year of life. Health of child. 2009; 5: 16-19. Ukrainian (Сенаторова А.С., Кондратова И.Ю. Сухоруков В.С. Энергодефицитные состояния как фактор риска осложненного течения пневмоний у детей первого года жизни //Здоровье ребенка. 2009. № 5. С. 16-19)