THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA
Main Article Content
Abstract
Violation of lipid metabolism with the formation of atherogenic factors and subsequent endothelial dysfunction is one of the concepts explaining the pathogenesis of preeclampsia.
Polymorphism of ApoE, CETP, and LPL genes can influence the course of pregnancy, provoking maternal dyslipidemia.
The aim of the study – to study the clinical and anemnestic features of patients with preeclampsia and women with a high risk of preeclampsia; to compare the data of biochemical tests of the data of both groups of patients, as well as to determine the role of polymorphism of lipid metabolism genes as risk factors for preeclampsia.
Materials and methods. A prospective cohort comparative study of 60 patients was conducted, of which the main group consisted of 30 women with moderate and severe preeclampsia and 30 patients with a high risk of developing preeclampsia according to prenatal screening of the first trimester, who made up the comparison group. In the course of the study, anamnestic factors, features of lipid metabolism and the results of genetic studies were analyzed.
Conclusion. The conducted studies showed a significant difference in the features of the obstetric and gynecological anamnesis of both groups of patients, lipidogram indicators, as well as in the distribution of alleles and genotypes in the group of women with realized preeclampsia by polymorphic markers ApoE 388 T>C and CETP 1264 G>A. There was no difference in the distribution of alleles and genotypes of the LPL 447 C>G gene.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Fetisova IN, Panova IA, Rokotyanskaya EA, Ratnikova SYu, Smirnova EV, Fetisov NS. The genetic factors which exert influence on preeclampsia development. Bulletin of the Ivanovo Medical Academy. 2015; 20(3): 13-16. Russian (Фетисова И.Н., Панова И.А., Рокотянская Е.А. Ратникова С.Ю., Смирнова Е.В., Фетисов Н.С. Генетические факторы развития преэклампсии //Вестник Ивановской медицинской академии. 2015. Т. 20, № 3. С. 13-16)
Jim B, Karumanchi SA. Preeclampsia: pathogenesis, prevention and long-term complications. Semin Nephrol. 2017; 37(4): 386-397. doi: 10.1016/j.semnephrol.2017.05.011
Pylaeva NYu, Shifman EM, Kulikov AV, Artymuk NV, Belokrinitskaya TE, Filippov OS, Babich TY. Preeclampsia. Eclampsia. Anesthesia and intensive care in childbirth and the postpartum period. Literature review. Bulletin of Intensive Care named after A.I. Saltanov. 2020; 1: 41-52. Russian (Пылаева Н.Ю., Шифман Е.М., Куликов А.В., Артымук Н.В., Белокриницкая Т.Е., Филиппов О.С., Бабич Т.Ю. Преэклампсия. Эклампсия. Анестезия и интенсивная терапия в родах и послеродовом периоде. Обзор литературы //Вестник интенсивной терапии им. А.И. Салтанова. 2020. № 1. С. 41-52.) doi: 10.21320/1818-474X-2020-1-41-52
Frolova NI, Belokrinitskaya TE, Kolmakova KА. Molecular markers and epigenetic risk factors of preeclampsia in the era of predictive medicine. Gynecology, Obstetrics and Perinatology. 2019; 18(4): 95-103. Russian (Фролова Н.И., Белокриницкая Т.Е., Колмакова К.А. Молекулярные маркеры и эпигенетические факторы риска преэклампсии в эпоху предиктивной медицины //Вопросы гинекологии, акушерства и перинатологии. 2019. Т. 18, № 4. С. 95-103.) doi: 10.20953/1726-1678-20194-95-103
Morgoyeva AA, Tsakhilovа SG, Sakvarelidze NYu, Zikova AS, Olisayeva IV. The Role of Extracellular Vesicles in the Development of Endothelial Dysfunction in Preeclampsia. Effective Pharmacotherapy. Obstetrics and gynecology. 2021; 17(32): 8-12. Russian (Моргоева А.А., Цахилова С.Г., Сакварелидзе Н.Ю., Зыкова А.С., Олисаева О.В. Роль внеклеточных везикул в развитии эндотелиальной дисфункции при преэклампсии //Эффективная фармакотерапия. Акушерство и гинекология. 2021. Т. 17, № 32. С. 8-12.) doi: 10.33978/2307-3586-2021-17-32-8-12
Khodzhaeva ZS, Kholin AM, Shuvalova MP, Ivanets TYu, Demura SA, Galichkina IV. A russian model for evaluating the efficiency of the sFlt-1/PlGF test for preeclampsia. Obstetrics and gynecology. 2019; 2: 52-58. Russian (Ходжаева З.С., Холин А.М., Шувалова М.П., Иванец Т.Ю., Демура С.А., Галичкина И.В. Российская модель оценки эффективности теста на преэклампсию sFlt-1/PlGF //Акушерство и гинекология. 2019. № 2. С. 52-58.) doi: 10.18565/aig.2019.2.52-58
Masini G, Foo LF, Tay J, Wilkinson IB, Valensise H, Gyselaers W, Lees CC. Preeclampsia has two phenotypes which require different treatment strategies. Am J Obstet Gynecol. 2022; 226(2S): S1006-S1018. doi: 10.1016/j.ajog.2020.10.052
Sidorova IS, Nikitina NA. Features of the pathogenesis of endotheliosis in preeclampsia. Obstetrics and gynecology. 2015; 1: 72-78. Russian (Сидорова И.С., Никитина Н.А. Особенности патогенеза эндотелиоза при преэклампсии //Акушерство и гинекология. 2015. № 1. С. 72-78)
Yang Y, Wang Y, Lv Y, Ding H. Dissecting the Roles of Lipids in Preeclampsia. Metabolites. 2022; 12(7): 590. doi: 10.3390/metabo12070590
Melhem H, Kallol S, Huang X, Lüthi M, Ontsouka CE, Keogh A, et al. Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta. Sci Rep. 2019; 9(1): 6225. doi: 10.1038/s41598-019-42522-1
Jacobsen DP, Fjeldstad HE, Johnsen GM, Fosheim IK, Moe K, Alnæs-Katjavivi P, et al. Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health. Front Immunol. 2021; 12: 791606. doi: 10.3389/fimmu.2021.791606
Sobolevskaya IS, Myadelets OD, Semyonov VM, Zykova OS, Sobolevsky SL, Pashinskaya ES. Structural and functional features of some genes involved in lipid metabolism and transport. Vitebsk Medical Jornal. 2018; 17(5): 17-27. Russian (Соболевская И.С., Мяделец О.Д., Семёнов В.М., Зыкова О.С., Соболевский С.Л., Пашинская Е.С. Структурные и функциональные особенности некоторых генов, участвующих в метаболизме и транспорте липидов //Вестник ВГМУ. 2018. Т. 17, № 5. С. 17-27)
Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S. Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol. 2013; 33(4): 687-693. doi: 10.1161/ATVBAHA.112.301193
Morgen K, Ramirez A, Frölich L, Tost H, Plichta MM, Kölsch H, et al. Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. Alzheimers Dement. 2014; 10(5 Suppl): S269-276. doi: 10.1016/j.jalz.2013.11.001
Malashenkova IK, Krynskiy SA, Mamoshina MV, Didkovskiy NA. APOE gene polymorphism: the impact of APOE4 allele on systemic inflammation and its role in the pathogenesis of Alzheimer’s disease. Medical Immunology (Russia). 2018; 20(3): 303-312. Russian (Малашенкова И.К., Крынский С.А., Мамошина М.В., Дидковский Н.А. Полиморфизм гена ApoE: влияние аллеля ApoE4 на системное воспаление и его роль в патогенезе болезни Альцгеймера //Медицинская иммунология. 2018. Т. 20, № 3. С. 303-312.) doi: 10.15789/1563-0625-2018-3-303-312
National Library of Medicine: https://www.ncbi.nlm.nih.gov/clinvar/variation/17864/?new_evidence=true
Papp AC, Pinsonneault JK, Wang D, Newman LC, Gong Y, Johnson JA, et al. Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS One. 2012; 7(3): e31930. doi: 10.1371/journal.pone.0031930
ClinVar Miner: https://clinvarminer.genetics.utah.edu/submissions-by-variant/NM_000078.3%28CETP%29%3Ac.1264G%3EA%20%28p.Val422Ile%29
Tabikhanova LE, Osipova LP, Voronina EN, Bragin AO, Filipenko ML. Polymorphism of lipid exchange genes in some populations of South and East Siberia. Vavilov Journal of Genetics and Breeding. 2019; 23(8): 1011-1019. Russian (Табиханова А.Э., Осипова Л.П., Воронина Е.Н., Брагин А.О., Филипенко М.Л. Полиморфизм генов липидного обмена в некоторых популяциях Южной и Восточной Сибири //Вавиловский журнал генетики и селекции. 2019. Т. 23, № 8. С. 1011-1019.) doi: 10.18699/VJ19.578
Clinical recommendations «Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, childbirth and the postpartum period», 2021. Russian (Клинические рекомендации «Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и в послеродовом периоде», 2021