LIMITED MEANINGS OF ANTIBODIES TO ESTRADIOL, PROGESTERONE AND BENZO[A]PYRENE AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANES IN WOMEN WITH PRETERM PREGNANCY
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Abstract
The aim of this study was to determine the limits of antibodies Ig classes A and G to estradiol (Es), progesterone (Pg), and benzo[a]pyrene (Bp) as a risk factors for premature rupture of membranes (PROM) in preterm pregnancy.
A retrospective, comparative, analytical study was taken. The study included 149 patients, group I consisted of women with PROM at 22-36,6 weeks of gestation (n = 68), group II – women without PROM in terms 22-36,6 weeks (n = 81).
Statistically significant differences in the formation of antibodies Ig to Es were observed in women in group I in comparison with women in group II. If IgA level to Es is > 5, it’s a risk factor of PROM in terms 22-36,6 weeks.
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Artimuk NV, Elizarova NN, Kolesnikova NB, Pavlovskaya DV, Chernyaeva VI. Peculiarities of pregnancy and delivery, the state of newborns in case of premature rupture of membranes and preterm pregnancy. Gynecology. 2016; 18(1): 64-67. Russian (Артымук Н.В., Елизарова Н.Н., Колесникова Н.Б., Павловская Д.В., Черняева В.И. Особенности беременности, родов и состояния новорожденных при преждевременном разрыве плодных оболочек и недоношенной беременности //Гинекология. 2016. 18(1). С. 64-67.)
Kuzibaeva RK, Hadartseva KA. The structure and incidence of premature births in nulliparous Journal of new medical technologies. The electronic edition. 2015. 2. Publication 2-3. Access mode: http://www.medtsu.tula.ru/ VNMT/Bulletin/E2015-2/5118.pdf. DOI: 10.12737/1081. Russian (Кузибаева Р.К., Хадарцева К.А. Структура и частота преждевременных родов у первородящих //Вестник новых медицинских технологий. Электронное издание. 2015. № 2. Публикация 2-3. Режим доступа: http://www.medtsu.tula.ru/ VNMT/Bulletin/E2015-2/5118.pdf. DOI: 10.12737/10811)
Clinical management guidelines for obstetrician-gynecologists /ACOG Committee on Practice Bulletins-Obstetrics, authors. ACOG Practice Bulletin N 160: premature rupture of membranes. Obstet Gynecol. 2016. P. 127
Kuklina EM. Cellular and molecular mechanisms of immunomodulatory activity of reproductive hormones: Doctor biol. sci. abstracts diss. Perm, 2003. 27 p. Russian (Куклина Е.М. Клеточные и молекулярные механизмы иммуномодулирующей активности репродуктивных гормонов: Автореф. дис. … доктора биол. наук. Пермь, 2003. 27 с.)
Nikitin AI. Hormone-like xenobiotics and their role in the pathology of human reproductive function. Human ecology. 2006; (1): 9-16. Russian (Никитин А.И. Гормоноподобные ксенобиотики и их роль в патологии репродуктивной функции человека //Экология человека. 2006. № 1. С. 9-16.)
Le Vee M, Kolasa E, Jouan E, Collet N, Fardel O. Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene. Chem Biol Interact. 2014; Mar 5. (210): 1-11. Doi: 10.1016/j.cbi.2013.12.004. Epub 2013 Dec 17
Zhao Y, Chen X, Liu X, Ding Y, Gao R, Qiu Y, Wang Y, He J. Exposure of mice to benzo(a)pyrene impairs endometrial receptivity and reduces the number of implantation sites during early pregnancy. Food Chem Toxicol. 2014; Jul (69): 244-251. Doi: 10.1016/j.fct.2014.04.021. Epub 2014 Apr 24
Glushkov AN. Immunological mechanisms of adaptation to the low-weight chemical compounds in onto-genesis. Medical Hypotheses. 2003; 61(3): 405-411
Fadiel A, Epperson B, Shaw MI, Hamza A, Petito J, Naftolin F. Bioinformatic analysis of benzo-α-pyrene-induced damage to the human placental insulin-like growth factor-1 gene. Reprod Sci. 2013; Aug. 20(8): 917-928. Doi: 10.1177/1933719112468946. Epub 2013 Jan 23
Greiner M, Pfeiffer D, Smith RD. Priciples and practical application of the receiver operating characteristic analysis for diagnostic test. Prev. Vet. Med. 2000; (45): 23-41
Krasylnikova KS, Polenok YeG, Anosova TP, Anosov MP, Kostyanko MV, Raving LS, Nersesyan SL, Olennikova RV, Goreyeva YuV, Sutulina IM, Karas IYu, Glushkov AN. The characteristics of formation of antibodies to xeno- and endobiotics in women with inherent malformation of fetus. Clinical laboratory diagnostics. 2012; (4): 24-25. Russian (Красильникова К.С., Поленок Е.Г., Аносова Т.П., Аносов М.П., Костянко М.В., Равинг Л.С., Нерсесян С.Л., Оленникова Р.В., Гореева Ю.В., Сутулина И.М., Карась И.Ю., Глушков А.Н. Особенности образования антител к ксено- и эндобиотикам у женщин с врожденными пороками развития плода //Клиническая лабораторная диагностика. 2012. № 4. С. 24-25.)
Itsekson Alek M. Steroid hormone hypersensitivity: clinical presentation and management. Fertil Steril. 2011; (95): 2571-2573
Bernstein IL, Bernstein DI, Lummus ZL, Bernstein JA. A case of progesterone-induced anaphylaxis, cyclic urticaria/angioedema, and autoimmune dermatitis. J Womens Health (Larchmt). 2011; Apr. 20(4): 643-648. Doi: 10.1089/jwh.2010.2468. Epub 2011 Mar 18
Gladkova K.A. The role of sensitization to progesterone in the clinic habitual miscarriage of pregnancy: Candidate med. sci. abstracts diss. M., 2008. 23 р. Russian (Гладкова К.А. Роль сенсибилизации к прогестерону в клинике привычного невынашивания беременности: Автореф. дис. … канд. мед. наук. М., 2008. 23 с.)
Prieto-Garcia A, Sloane DE, Gargiulo AR, Feldweg AM, Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril. 2011; (5): 1121-1129