STATE OF URINARY SYSTEM ORGANS AND BLOOD PLASMA NGAL LEVEL IN ACUTE INTESTINAL INFECTIONS COMPLICATED BY INTESTINAL TOXICOSIS WITH EXCOSIS IN CHILDREN
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Abstract
The aim of the research – to determine GFR and NGAL blood plasma indicators in children with complicated forms of AII to optimize approaches to diagnosis and therapy.
Materials and methods. We observed 51 children aged from 2 months to 6 years with a diagnosis of AII, complicated by toxicosis with exicosis of the II degree. All patients underwent a complex of clinical and biochemical studies. The level of NGAL blood plasma was determined by the ELISA method for the admitted children on the first day.
The results of the study. Viruses were the etiological factor in 86 % of the examined children, 37 % of children had a viral-bacterial etiology, monobacterial AII was diagnosed in 14 % of the children included in the study. Changes in urinary sediment of proteinuria (43 %), microhematuria (6 %), pathological leukocyturia (20 %) and crystalluria (27 %) were registered. The level of plasma creatinine was increased in a third of the examined children. A decrease in GFR was registered in 71 % of children with complicated AII.
The correlation analysis showed the presence of a relationship between the level of hemoglobin, GFR, creatinine and blood plasma leukocytes, NGAL in children in age groups and depending on the etiology.
Conclusion. Among the examined children with complicated AII, viruses were the etiological factor of AII in most cases (86 %). The results of the study made it possible to establish the presence of kidney damage in a significant part of the examined children in the form of pathological changes in the urinary sediment with a high frequency of proteinuria, pathological leukocyturia, microhematuria and crystalluria. Increased plasma creatinine levels and decreased GFR. The value of the blood plasma NGAL level, as one of the earliest and most studied biomarkers of AKI, has been shown in all age groups and in groups depending on the etiology of AII.
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Author Biographies
Евгения Юрьевна Киричек, Altai State Medical University, Barnaul
assistant, department of pediatrics with the course of APEГалина Ивановна Выходцева, Altai State Medical University, Barnaul
doctor of medical sciences, professor, department of pediatrics with a course APEОльга Петровна Морозова, Altai State Medical University, Barnaul
candidate of medical sciences, docent, department of pediatrics with a course APEЛюдмила Ивановна Зиновьева, Altai State Medical University, Barnaul
candidate of medical sciences, docent, department of pediatrics with a course APEЕвгений Васильевич Скударнов, Altai State Medical University, Barnaul
Skudarnov Evgeny Vasilyevich
MD, PhD, professor, professor of the department of pediatrics with course FPK and PPS.
He is a professor of the Department of Pediatrics №1, Vice-Dean of the Pediatric Department, the pediatrician of the highest qualification category, cardiologist of the highest qualification category.
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