Main Article Content
Abstract
The aim of the research – to improve the results of management of pregnant women with large uterine leiomyoma by introducing an integrated approach.
Materials and methods. 120 pregnant women with large uterine fibroids (more than 8 cm) were observed. The main group was observed using an integrated approach: micronized progesterone intravaginally combined with the installation of an obstetric pessary. The comparison group was conducted in accordance with current clinical guidelines. According to indications, myomectomy was performed during pregnancy. Depending on the myomectomy performed, the groups were divided into subgroups.
Results. In the main group, against the background of the combined method of management, the threat of miscarriage was observed less frequently, the frequency of preterm birth (PTB) significantly decreased, fetal malnutrition and premature abruption of a normally located placenta were less frequently observed, and the need for myomectomy during pregnancy arose half as often. Myomectomy additionally reduced the number of PRs in subgroups by two to five times compared to patients who did not undergo myomectomy.
Conclusion. The developed algorithm for the management of pregnant women with large uterine leiomyomas made it possible to significantly prolong pregnancy to full term and reduce the number of organ-loss operations. The developed technique for performing myomectomy during pregnancy allows us to minimize surgical risks, promotes the formation of a full-fledged scar on the uterus, and prolongs pregnancy.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Egbe TO, Badjang TG, Tchounzou R, Egbe EN, Ngowe MN. Uterine fibroids in pregnancy: prevalence, clinical presentation, associated factors and outcomes at the Limbe and Buea Regional Hospitals, Cameroon: a cross-sectional study. BMC Res Notes. 2018; 11(1): 889. doi: 10.1186/s13104-018-4007-0
Sobel M, Hobson S, Chan C. Uterine fibroids in pregnancy. CMAJ. 2022; 194(22): E775. doi: 10.1503/cmaj.211530
Eyong E, Okon O. Large Uterine Fibroids in Pregnancy with Successful Caesarean Myomectomy. Case Rep Obstet Gynecol. 2020; 2020: 8880296. doi: 10.1155/2020/8880296
Parazzini F, Tozzi L, Bianchi S. Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016; 34: 74-84. doi: 10.1016/j.bpobgyn.2015.11.017
Ciavattini A, Delli Carpini G, Clemente N, Moriconi L, Gentili C, Di Giuseppe J. Growth trend of small uterine fibroids and human chorionic gonadotropin serum levels in early pregnancy: an observational study. Fertil Steril. 2016; 105(5): 1255-1260. doi: 10.1016/j.fertnstert.2016.01.032
Chill HH, Karavani G, Rachmani T, Dior U, Tadmor O, Shushan A. Growth pattern of uterine leiomyoma along pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016; 34: 74-84. doi: 10.1016/j.bpobgyn.2015.11.017
Vitagliano A, Noventa M, Di Spiezio Sardo A, Saccone G, Gizzo S, Borgato S, et al. Uterine fibroid size modifications during pregnancy and puerperium: evidence from the first systematic review of literature. Arch Gynecol Obstet. 2018; 297(4): 823-835. doi: 10.1007/s00404-017-4621-4
Basso A, Catalano MR, Loverro G, Nocera S, Di Naro E, Loverro M, et al. Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks' Gestation with Systematic Review of the Literature. Case Rep Obstet Gynecol. 2017; 2017: 4970802. doi: 10.1155/2017/4970802
Ming WK, Wu H, Wu Y, Chen H, Meng T, Shen Y, et al. Health-related quality of life in pregnancy with uterine fibroid: a cross-sectional study in China. Health Qual Life Outcomes. 2019; 17(1): 89. doi: 10.1186/s12955-019-1153-6
Saleh HS, Mowafy HE, Hameid AE, Sherif HE, Mahfouz EM. Does Uterine Fibroid Adversely Affect Obstetric Outcome of Pregnancy? Biomed Res Int. 2018; 2018: 8367068. doi: 10.1155/2018/8367068
Sulaimani R, Machado L, Salmi M. Do Large Uterine Fibroids Impact Pregnancy Outcomes? Oman Med J. 2021; 36(4): e292. doi: 10.5001/omj.2021.93
Levast F, Legendre G, Bouet PE, Sentilhes L. Management of uterine myomas during pregnancy. Gynecol Obstet Fertil. 2016; 44(6): 350-354. doi: 10.1016/j.gyobfe.2016.04.007
Parazzini F, Tozzi L, Bianchi S. Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016; 34: 74-84. doi: 10.1016/j.bpobgyn.2015.11.017
Sundermann AC, Velez Edwards DR, Bray MJ, Jones SH, Latham SM, Hartmann KE. Leiomyomas in Pregnancy and Spontaneous Abortion: A Systematic Review and Meta-analysis. Obstet Gynecol. 2017; 130(5): 1065-1072. doi: 10.1097/AOG.0000000000002313
Sundermann A, Aldridge T, Hartmann K, Jones S, Torstenson E, Edwards D. Uterine fibroids and risk of preterm birth by clinical subtypes: a prospective cohort study. BMC Pregnancy Childbirth. 2021; 21(1): 560. doi: 10.1186/s12884-021-03968-2
Ciavattini A, Clemente N, Delli Carpini G, Di Giuseppe J, Giannubilo SR, Tranquilli AL. Number and size of uterine fibroids and obstetric outcomes. J Matern Fetal & Neonatal Med. 2015; 28(4): 484-488. doi: 10.3109/14767058.2014.921675
Goya M, de la Calle M, Pratcorona L, Merced C, Rodó C, Muñoz B, et al. Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol. 2016; 214(2): 145-152. doi: 10.1016/j.ajog.2015.11.012
Arabin B, Alfirevic Z. Cervical pessaries for prevention of spontaneous preterm birth: past, present and future. Ultrasound Obst Gynecol. 2013; 42(4): 390-399. doi: 10.1002/uog.12540
Kan NE, Tyutyunnik VL, Lomova NA. Natural micronized progesterone in complex therapy of threatened premature birth. Obstetrics and gynecology: News, Opinions, Training. 2018; 2: 83-87. Russian (Кан Н.E., Тютюнник В.Л., Ломова Н.А. Натуральный микронизированный прогестерон в комплексной терапии угрожающих преждевременных родов //Акушерство и гинекология: новости, мнения, обучение. 2018. № 2. С. 83-87.) doi: 10.24411/2303-9698-2018-00020
