СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О ПАТОФИЗИОЛОГИИ АТЕРОСКЛЕРОЗА. ЧАСТЬ 1. РОЛЬ НАРУШЕНИЯ ОБМЕНА ЛИПИДОВ И ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ (ОБЗОР ЛИТЕРАТУРЫ)


Чаулин А.М., Григорьева Ю.В., Дупляков Д.В.

Аннотация


По современным представлениям атеросклероз является хроническим воспалительным заболеванием сосудистой стенки, которое характеризуется накоплением (аккумуляцией) липидов, пролиферацией гладкомышечных клеток сосудов, апоптозом, некрозом клеток, фиброзом и локальным воспалением. В патофизиологии атеросклероза принимают участие многочисленные механизмы, среди которых ключевую роль играют нарушение метаболизма липидов и модификация липопротеинов низкой плотности, эндотелиальная дисфункция, иммунные и воспалительные процессы. Между данными механизмами существуют сложные и многокомпонентные взаимодействия, которые мы обсуждаем в данном обзоре.

В первой части обзора мы рассматриваем роль нарушения метаболизма липидов и эндотелиальной дисфункции в развитии атеросклероза.

Во второй части обзора будет рассмотрена роль иммунных и воспалительных механизмов в патогенезе атеросклероза.


Ключевые слова


обзор литературы; атеросклероз; обмен липидов; липопротеины низкой плотности (ЛПНП); окислительный стресс; эндотелий; дисфункция эндотелия; оксид азота (NO); эндотелин-1 (ET-1)

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Литература


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